TopFIND 4.0

O88777: Presenilin-2

General Information

Protein names
- Presenilin-2
- PS-2
- 3.4.23.-
- Presenilin-2 NTF subunit
- Presenilin-2 CTF subunit
Gene names Psen2
Organism Rattus norvegicus
Protease Family
Protease ID A22.002
Chromosome location
UniProt ID O88777

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLTFMASDSE EEVCDERTSL MSAESPTSRS CQDSRPGPED GENTAQWRSQ ENEDDCEEDP 
        70         80         90        100        110        120 
DHYACSGVPG RPSGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 
       130        140        150        160        170        180 
YTPFTEDTPS VGQRLLNSVL NTLIMISVIV VMTIFLVVLY KYRCYKFIHG WLIMSSLMLL 
       190        200        210        220        230        240 
FLFTYIYLGE VFKTYNVAMD YPTLFLAVWN FGAVGMVCIH WKGPLVLQQA YLIVISALMA 
       250        260        270        280        290        300 
LVFIKYLPEW SAWVILGAIS VYDLVAVLCP KGPLRMLVET AQERNEPIFP ALIYSSAMVW 
       310        320        330        340        350        360 
TVGMAKLDPS SQGALQLPYD PEMEEDSYDS FGEPSYPEAF EAPQPGYPGE EPEEEEERGV 
       370        380        390        400        410        420 
KLGLGDFIFY SVLVGKAAAT GNGDWSTTLA CFIAILIGLC LTLLLLAVFK KALPALPISI 
       430        440    
TFGLIFYFST DNLVRPFMDT LASHQLYI

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O88777-1-unknown MLTFMA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O88777-298-unknown MVWTVG... 298 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...IYSSAM 297 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...HQLYI 448 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)