O88783: Coagulation factor V
| Protein names | - Coagulation factor V - Activated protein C cofactor - Coagulation factor V heavy chain - Coagulation factor V light chain |
|---|---|
| Gene names | F5 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | O88783 |
4
N-termini
4
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLLVCPCFFL LVVLGTRWAG WGSHQAEAAQ LRQFYVAAQG ILWNYHPEPT DPSLNSIPSF
70 80 90 100 110 120
KKIVYREYEQ YFKKEKPRSS NSGLLGPTLY AEVGDVIKVH FRNKADKPLS IHPQGIKYSK
130 140 150 160 170 180
FSEGASYADH TFPAERKDDA VAPGEEYTYE WIVSEDSGPT PDDPPCLTHI YYSYENLTQD
190 200 210 220 230 240
FNSGLIGPLL ICKKGTLTED GTQKMFDKQH VLLFAVFDES KSRSQSPSLM YTINGFVNKT
250 260 270 280 290 300
MPDITVCAHD HVSWHLIGMS SGPELFSIHF NGQVLEQNQH KVSTVTLVSA TSTTANMTMS
310 320 330 340 350 360
PEGRWIVSSL IPKHYQAGMQ AYIDIKNCPK KTRSPKTLTR EQRRYMKRWE YFIAAEEVIW
370 380 390 400 410 420
NYAPVIPANM DKIYRSQHLD NFSNQIGKHY KKVIYRQYEE ETFTKRTDNP SIKQSGILGP
430 440 450 460 470 480
VIRAQVRDTL KIVFKNMASR PYSIYPHGVT FSPYEDGINS SSTSGSHTTI RPVQPGETFT
490 500 510 520 530 540
YKWNILEFDE PTENDAQCLT RPYYSDVDVT RDIASGLIGL LLICKSRSLD QRGVQRVADI
550 560 570 580 590 600
EQQAVFAVFD ENKSWYIEDN INKFCENPDE VKRDDPKFYE SNIMSTINGY VPESISTLGF
610 620 630 640 650 660
CFDDTVQWHF CSVGTHDDIL TIHFTGHSFI YGRRHEDTLT LFPMRGESVT VTMDNVGTWM
670 680 690 700 710 720
LTTMNSNPKR RNLRLRFRDV KCNRDYDNED SYEIYEPPAP TSMTTRRIHD SLENEFGIDN
730 740 750 760 770 780
EDDDYQYLLA SSLGIRSFKN SSLNPEENEF NLTALALENS SEFISPSTDR VVDSNSSRIL
790 800 810 820 830 840
SKIINNNLKD FQRTLPGSGA TVAGTLLRNL IGLDENFVLN SSTEHRSSSY HENDMENPQS
850 860 870 880 890 900
NITMVYLLPL GPKGSGNREQ DKPKTIKTGR PHMMKHRFSW MKAPAGKTGR HSNPKNSYSG
910 920 930 940 950 960
MKSEEDIPSE LIPLKQKITS KFLNRRWRVA SEKGSYEIIA ANGEDTDVDK LTNSPQNQNI
970 980 990 1000 1010 1020
TVPRGESTSH TNTTRKPSDL PTFSGVGHKS PHVRQEEENS GFQKRQLFIR TRKKKKNKKL
1030 1040 1050 1060 1070 1080
ALHSPLSPRG FDPLRGHNHS PFPDRRLLNH SLLLHKSNET ALSPDLNQTS PSMSTDRSLP
1090 1100 1110 1120 1130 1140
DYNQYSKNDT EQMSSSLDLY QSVPAEEHSP TFPAQDPDQT HSTTDPSYRS SPPELSQGLD
1150 1160 1170 1180 1190 1200
YDLSHDFYPD DIGLTSFFPD QSQKSSFSSD DDQAIPSSDL SLFTISPELD QTIIYPDLDQ
1210 1220 1230 1240 1250 1260
LLLSPEDNQK TSSPDLGQVP LSPDDNQKTS SPDLGQVSLS PDDNQKTSSP DLGQVPLSLD
1270 1280 1290 1300 1310 1320
DNQKTTSPDL GQVPLSPDDN QMITSPDLGQ VPLSSDNQKT SSPDLGQVPL FPEDNQNYFL
1330 1340 1350 1360 1370 1380
DLSQVPLSSD QNQETSSTDL LTLSPDFGQT VLSPDLDQLP LPSDNSQVTV SPDLSLLTLS
1390 1400 1410 1420 1430 1440
PDFNEIILAP DLGQVTLSPD LIQTNPALNH GHKASSADPD QASYPPDSGQ ASSLPELNRT
1450 1460 1470 1480 1490 1500
LPHPDLTHIP PPSPSPTLNN TSLSRKFNPL VVVGLSRVDG DDVEIVPSEE PERIDEDYAE
1510 1520 1530 1540 1550 1560
DDFVTYNDPY RTDTRTDVNS SRNPDTIAAW YLRGHGGHKK FYYIAAEEIT WNYAEFAQSE
1570 1580 1590 1600 1610 1620
MDHEDTGHTP KDTTYKKVVF RKYLDSTFTS RDPRAEYEEH LGILGPVIRA EVDDVIQVRF
1630 1640 1650 1660 1670 1680
KNLASRPYSL HAHGLSYEKS SEGKTYEDES PEWFQEDDAV QPNSSYTYVW HATKRSGPEN
1690 1700 1710 1720 1730 1740
PGSACRAWAY YSAVNVERDI HSGLIGPLLI CRKGTLHMER NLPMDMREFV LLFMVFDEKK
1750 1760 1770 1780 1790 1800
SWYYEKSKGS RRIESPEEKN AHKFYAINGM IYNLPGLRMY EQEWVRLHLL NMGGSRDIHV
1810 1820 1830 1840 1850 1860
VHFHGQTLLD NRTKQHQLGV WPLLPGSFKT LEMKASKPGW WLLDTEVGEN QVAGMQTPFL
1870 1880 1890 1900 1910 1920
IIDKECKMPM GLSTGVISDS QIKASEYLTY WEPRLARLNN AGSYNAWSIE KTALDFPIKP
1930 1940 1950 1960 1970 1980
WIQVDMQKEV VVTGIQTQGA KHYLKSCFTT EFQVAYSSDQ TNWQIFRGKS GKSVMYFTGN
1990 2000 2010 2020 2030 2040
SDGSTIKENR LDPPIVARYI RIHPTKSYNR PTLRLELQGC EVNGCSTPLG LEDGRIQDKQ
2050 2060 2070 2080 2090 2100
ITASSFKKSW WGDYWEPSLA RLNAQGRVNA WQAKANNNKQ WLQVDLLKIK KVTAIVTQGC
2110 2120 2130 2140 2150 2160
KSLSSEMYVK SYSIQYSDQG VAWKPYRQKS SMVDKIFEGN SNTKGHMKNF FNPPIISRFI
2170 2180
RIIPKTWNQS IALRLELFGC DIY
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| O88783-20-unknown | GWGSHQ... | 20 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O88783-334-unknown | SPKTLT... | 334 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34784 | |||
| O88783-533-unknown | GVQRVA... | 533 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34785 | |||
| O88783-1534-unknown | GHGGHK... | 1534 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O88783-1534-unknown | GHGGHK... | 1534 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...PKKTRS | 333 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34784 | |||
| ...SLDQRG | 532 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34785 | |||
| ...SLGIRS | 736 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...GCDIY | 2183 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| PROC_MOUSE | 333 | KTRS.|.SPKT | inferred from experiment | unknown | MEROPS | Ginsburg D | Yang TL et al.:The structure and function of m... (S01.218) | 9616155, |
| PROC_MOUSE | 532 | DQRG.|.GVQR | inferred from experiment | unknown | MEROPS | Ginsburg D | Yang TL et al.:The structure and function of m... (S01.218) | 9616155, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|