TopFIND 4.0

O88831: Calcium/calmodulin-dependent protein kinase kinase 2

General Information

Protein names
- Calcium/calmodulin-dependent protein kinase kinase 2
- CaM-KK 2
- CaM-kinase kinase 2
- CaMKK 2
- 2.7.11.17
- Calcium/calmodulin-dependent protein kinase kinase beta
- CaM-KK beta
- CaM-kinase kinase beta
- CaMKK beta
Gene names Camkk2
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID O88831

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSSCVSSQPT SDRAAPQDEL GSGGVSRESQ KPCEALRGLS SLSIHLGMES FIVVTECEPG 
        70         80         90        100        110        120 
RGVDLSLARD QPLEADGQEL PLDASEPESR SLLSGGKMSL QERSQGGPAS SSSLDMNGRC 
       130        140        150        160        170        180 
ICPSLSYSPA SSPQSSPRMP RRPTVESHHV SITGLQDCVQ LNQYTLKDEI GKGSYGVVKL 
       190        200        210        220        230        240 
AYNENDNTYY AMKVLSKKKL IRQAGFPRRP PPRGTRPAPG GCIQPRGPIE QVYQEIAILK 
       250        260        270        280        290        300 
KLDHPNVVKL VEVLDDPNED HLYMVFELVN QGPVMEVPTL KPLSEDQARF YFQDLIKGIE 
       310        320        330        340        350        360 
YLHYQKIIHR DIKPSNLLVG EDGHIKIADF GVSNEFKGSD ALLSNTVGTP AFMAPESLSE 
       370        380        390        400        410        420 
TRKIFSGKAL DVWAMGVTLY CFVFGQCPFM DERIMCLHSK IKSQALEFPD QPDIAEDLKD 
       430        440        450        460        470        480 
LITRMLDKNP ESRIVVPEIK LHPWVTRHGA EPLPSEDENC TLVEVTEEEV ENSVKHIPSL 
       490        500        510        520        530        540 
ATVILVKTMI RKRSFGNPFE GSRREERSLS APGNLLTKKP TREWEPLSEP KEARQRRQPP 
       550        560        570        580    
GPRASPCGGG GSALVKGGPC VESCGAPAPG SPPRTPPQQP EEAMEPE

Isoforms

- Isoform 2 of Calcium/calmodulin-dependent protein kinase kinase 2

Sequence View

        10         20         30         40         50         60 
MSSCVSSQPT SDRAAPQDEL GSGGVSRESQ KPCEALRGLS SLSIHLGMES FIVVTECEPG 
        70         80         90        100        110        120 
RGVDLSLARD QPLEADGQEL PLDASEPESR SLLSGGKMSL QERSQGGPAS SSSLDMNGRC 
       130        140        150        160        170        180 
ICPSLSYSPA SSPQSSPRMP RRPTVESHHV SITGLQDCVQ LNQYTLKDEI GKGSYGVVKL 
       190        200        210        220        230        240 
AYNENDNTYY AMKVLSKKKL IRQAGFPRRP PPRGTRPAPG GCIQPRGPIE QVYQEIAILK 
       250        260        270        280        290        300 
KLDHPNVVKL VEVLDDPNED HLYMVFELVN QGPVMEVPTL KPLSEDQARF YFQDLIKGIE 
       310        320        330        340        350        360 
YLHYQKIIHR DIKPSNLLVG EDGHIKIADF GVSNEFKGSD ALLSNTVGTP AFMAPESLSE 
       370        380        390        400        410        420 
TRKIFSGKAL DVWAMGVTLY CFVFGQCPFM DERIMCLHSK IKSQALEFPD QPDIAEDLKD 
       430        440        450        460        470        480 
LITRMLDKNP ESRIVVPEIK LHPWVTRHGA EPLPSEDENC TLVEVTEEEV ENSVKHIPSL 
       490        500        510        520        530        540 
ATVILVKTMI RKRSFGNPFE GSRREERSLS APGNLLTKKP TREWEPLSEP KEARQRRQPP 
       550        560        570        580    
GPRASPCGGG GSALVKGGPC VESCGAPAPG SPPRTPPQQP EEAMEPE



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O88831-1-unknown MSSCVS... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt192890
    O88831-2-unknown MSSCVS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O88831-2-Acetylation SSCVSS... 2 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O88831-2-Acetylation SSCVSS... 2 acetylation- inferred from isoform by sequence similarity unknown TopFIND inferred from TNt194523

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...AMEPE 587 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)