TopFIND 4.0

O89042: DNA polymerase alpha catalytic subunit

General Information

Protein names
- DNA polymerase alpha catalytic subunit
- 2.7.7.7
- DNA polymerase alpha catalytic subunit p180
Gene names Pola1
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID O89042

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAPVHGDDCK LETSAVSDSG SFVASRARRE KKSKKGRQEA LERLKKAKAG EKYKYEVEDL 
        70         80         90        100        110        120 
TSVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI FDDDLEDDAL DTCGEGSDGK 
       130        140        150        160        170        180 
AHRKDRKDVK KPSVTKPNNI KAMFIASAGK KTTDKTVDLS KDDLLGDILQ DLNTETPQIA 
       190        200        210        220        230        240 
PPPVLIPKKK RSTGASPNPF SVHTATAVPS GKIASPVSRK EPPLTPVPLK RAEFAGDLAQ 
       250        260        270        280        290        300 
PECPEDEQES GVIEFEDGDF DEPMDTEEVD EEEPVTAKIW DQESEPVEGV KHEADPETGT 
       310        320        330        340        350        360 
TSFLDSFLPD VSCWDIDQKD ENSFLLQEVQ VDSNHLPLVK GADDEQVFQF YWLDAYEDPY 
       370        380        390        400        410        420 
NQPGVVFLFG KVWVESAKTH VSCCVMVKNI ERTLYFLPRE MKIDLNTGKE TATPITMKDV 
       430        440        450        460        470        480 
YEEFDSKISA KYKIMKFKSK IVEKNYAFEI PDVPEKSEYL EVRYSAEVPQ LPQNLKGETF 
       490        500        510        520        530        540 
SHVFGTNTSS LELFLMNRKI KGPCWLEVKN PQLLNQPISW CKFEAMALKP DLVNVIKDVS 
       550        560        570        580        590        600 
PPPLVVMSFS MKTMQNVQNH QHEIIAMAAL VHHNFPLDKA PPKPPFQTHF CVVSKPKDCI 
       610        620        630        640        650        660 
FPCAFKEVIK KKNMEVEVAA TERTLLGFFL AKVHKLDPDI LVGHNICGFE LEVLLQRINE 
       670        680        690        700        710        720 
CKVPFWSKIG RLRRSNMPKL GSRSGFGERN ATCGRMICDV EISVKELIHC KSYHLSELVQ 
       730        740        750        760        770        780 
QILKTERIVI PTENIRNMYS EPSHLLYLLE HIWKDARFIL QIMCELNVLP LALQITNIAG 
       790        800        810        820        830        840 
NIMSRTLMGG RSERNEFLLL HAFYENNYIV PDKQIFRKPQ QKPGDEDEEI DGDTNKYKKG 
       850        860        870        880        890        900 
RKKAAYAGGL VLDPKVGFYD KFILLLDFNS LYPSIIQEFN ICFTTVQRVA SETLKATEDE 
       910        920        930        940        950        960 
EQEQIPELPD PNLDMGILPR EIRKLVERRK QVKQLMKQQD LNPDLVLQYD IRQKALKLTA 
       970        980        990       1000       1010       1020 
NSMYGCLGFS YSRFYAKPLA ALVTYKGREI LMHTKEMVQK MNLEVIYGDT DSIMINTNST 
      1030       1040       1050       1060       1070       1080 
NLEEVFKLGN KVKNEVNKLY KLLEIDIDGV FKSLLLLKKK KYAALVVEPT SDGNYITKQE 
      1090       1100       1110       1120       1130       1140 
LKGLDIVRRD WCDLAKDTGN FVIGQILSDQ SRDTIVENIQ KRLIEIGENV LNGSVPVSQF 
      1150       1160       1170       1180       1190       1200 
EINKALTKDP QDYPDKKSLP HVHVALWINS QGGRKVKAGD TVSYVICQDG SNLPATQRAY 
      1210       1220       1230       1240       1250       1260 
APEQLQKQDN LAIDTQYYLA QQIHPVVARI CEPIDGIDAV LIALWLGLDS TQFRVHQYHK 
      1270       1280       1290       1300       1310       1320 
DEENDALLGG PAQLTDEEKY KDCEKFKCLC PSCGTENIYD NVFEGSGMDM EPSLNRCSNI 
      1330       1340       1350       1360       1370       1380 
DCKASPATFM VQLSNKLIMD IRRCIKKYYD GWLICEEPTC RNRIRRLPLH FSRNGPLCPA 
      1390       1400       1410       1420       1430       1440 
CMKAVLRPEY SDKSLYTQLC FYRYIFDADC ALEKLPEHEK DKLKKQFFTP RVLQDYRKVK 
      1450    
NIAEHFLSWS G

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O89042-1-unknown MAPVHG... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LSWSG 1451 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)