O94782: Ubiquitin carboxyl-terminal hydrolase 1

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 1 - 3.4.19.12 {ECO:0000269\|PubMed:15694335, ECO:0000269\|PubMed:16531995, ECO:0000269\|PubMed:18082604, ECO:0000269\|PubMed:26388029, ECO:0000269\|PubMed:9806842} - Deubiquitinating enzyme 1 - hUBP - Ubiquitin thioesterase 1 - Ubiquitin-specific-processing protease 1
Gene names	USP1
Organism	Homo sapiens
Protease Family
Protease ID	C19.019
Chromosome location
UniProt ID	O94782

2 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKAS EYRASEIDQV
        70         80         90        100        110        120
VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKSGVK HLFNIISRKK
       130        140        150        160        170        180
EALKDEANQK DKGNCKEDSL ASYELICSLQ SLIISVEQLQ ASFLLNPEKY TDELATQPRR
       190        200        210        220        230        240
LLNTLRELNP MYEGYLQHDA QEVLQCILGN IQETCQLLKK EEVKNVAELP TKVEEIPHPK
       250        260        270        280        290        300
EEMNGINSIE MDSMRHSEDF KEKLPKGNGK RKSDTEFGNM KKKVKLSKEH QSLEENQRQT
       310        320        330        340        350        360
RSKRKATSDT LESPPKIIPK YISENESPRP SQKKSRVKIN WLKSATKQPS ILSKFCSLGK
       370        380        390        400        410        420
ITTNQGVKGQ SKENECDPEE DLGKCESDNT TNGCGLESPG NTVTPVNVNE VKPINKGEEQ
       430        440        450        460        470        480
IGFELVEKLF QGQLVLRTRC LECESLTERR EDFQDISVPV QEDELSKVEE SSEISPEPKT
       490        500        510        520        530        540
EMKTLRWAIS QFASVERIVG EDKYFCENCH HYTEAERSLL FDKMPEVITI HLKCFAASGL
       550        560        570        580        590        600
EFDCYGGGLS KINTPLLTPL KLSLEEWSTK PTNDSYGLFA VVMHSGITIS SGHYTASVKV
       610        620        630        640        650        660
TDLNSLELDK GNFVVDQMCE IGKPEPLNEE EARGVVENYN DEEVSIRVGG NTQPSKVLNK
       670        680        690        700        710        720
KNVEAIGLLG GQKSKADYEL YNKASNPDKV ASTAFAENRN SETSDTTGTH ESDRNKESSD
       730        740        750        760        770        780
QTGINISGFE NKISYVVQSL KEYEGKWLLF DDSEVKVTEE KDFLNSLSPS TSPTSTPYLL

FYKKL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O94782-1-unknown	MPGVIP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O94782-42-unknown	SQENEE...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1506

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LDFTDS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1506
...LNNLGN	87	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387986
...LNTLRE	186	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403662
...FYKKL	785	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	41	FTDS.\|.SQEN	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> UBP1_HUMAN @41

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)