O94910: Adhesion G protein-coupled receptor L1 {ECO:0000312|HGNC:HGNC:20973}

General Information

Protein names	- Adhesion G protein-coupled receptor L1 {ECO:0000312\|HGNC:HGNC:20973} - Calcium-independent alpha-latrotoxin receptor 1 {ECO:0000250\|UniProtKB:O88917} - CIRL-1 {ECO:0000250\|UniProtKB:O88917} - Latrophilin-1 {ECO:0000312\|HGNC:HGNC:20973} - Lectomedin-2
Gene names	LPHN1
Organism	Homo sapiens
Protease Family	S63.013
Protease ID	S63.013
Chromosome location
UniProt ID	O94910

3 N-termini

2 C-termini

1 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC PGSDVIMVEN
        70         80         90        100        110        120
ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT QCVVVAGSDA FPDPCPGTYK
       130        140        150        160        170        180
YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP TSTHESEHQS GAWCKDPLQA GDRIYVMPWI
       190        200        210        220        230        240
PYRTDTLTEY ASWEDYVAAR HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT
       250        260        270        280        290        300
RIKSGETVIN TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL
       310        320        330        340        350        360
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT NANREEPVSL
       370        380        390        400        410        420
TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD PSAGPATSPP LSTTTTARPT
       430        440        450        460        470        480
PLTSTASPAA TTPLRRAPLT THPVGAINQL GPDLPPATAP VPSTRRPPAP NLHVSPELFC
       490        500        510        520        530        540
EPREVRRVQW PATQQGMLVE RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV
       550        560        570        580        590        600
AQKIKSGENA ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG
       610        620        630        640        650        660
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM LLDVLEEGAF
       670        680        690        700        710        720
LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE EYPRKNSIQL SAKTIKQNSR
       730        740        750        760        770        780
NGVVKVVFIL YNNLGLFLST ENATVKLAGE AGPGGPGGAS LVVNSQVIAA SINKESSRVF
       790        800        810        820        830        840
LMDPVIFTVA HLEDKNHFNA NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN
       850        860        870        880        890        900
FAVLMAHREI YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC
       910        920        930        940        950        960
INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL LLVEVFESEY
       970        980        990       1000       1010       1020
SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD NYFIWSFIGP VSFVIVVNLV
      1030       1040       1050       1060       1070       1080
FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA LGAIALLFLL GLTWAFGLLF INKESVVMAY
      1090       1100       1110       1120       1130       1140
LFTTFNAFQG VFIFVFHCAL QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR
      1150       1160       1170       1180       1190       1200
YYTGTQSRIR RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY
      1210       1220       1230       1240       1250       1260
NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN SYSLRSGDFP
      1270       1280       1290       1300       1310       1320
PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA KGPPPPEPPV PPVPGGGGEE
      1330       1340       1350       1360       1370       1380
EAGGPGGADR AEIELLYKAL EEPLLLPRAQ SVLYQSDLDE SESCTAEDGA TSRPLSSPPG
      1390       1400       1410       1420       1430       1440
RDSLYASGAN LRDSPSYPDS SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY
      1450       1460       1470
YQVRRPSHEG YLAAPGLEGP GPDGDGQMQL VTSL

Isoforms

- Isoform 2 of Latrophilin-1 - Isoform 2 of Adhesion G protein-coupled receptor L1

Sequence View

        10         20         30         40         50         60
MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC PGSDVIMVEN
        70         80         90        100        110        120
ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT QCVVVAGSDA FPDPCPGTYK
       130        140        150        160        170        180
YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP TSTHESEHQS GAWCKDPLQA GDRIYVMPWI
       190        200        210        220        230        240
PYRTDTLTEY ASWEDYVAAR HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT
       250        260        270        280        290        300
RIKSGETVIN TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL
       310        320        330        340        350        360
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT NANREEPVSL
       370        380        390        400        410        420
TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD PSAGPATSPP LSTTTTARPT
       430        440        450        460        470        480
PLTSTASPAA TTPLRRAPLT THPVGAINQL GPDLPPATAP VPSTRRPPAP NLHVSPELFC
       490        500        510        520        530        540
EPREVRRVQW PATQQGMLVE RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV
       550        560        570        580        590        600
AQKIKSGENA ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG
       610        620        630        640        650        660
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM LLDVLEEGAF
       670        680        690        700        710        720
LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE EYPRKNSIQL SAKTIKQNSR
       730        740        750        760        770        780
NGVVKVVFIL YNNLGLFLST ENATVKLAGE AGPGGPGGAS LVVNSQVIAA SINKESSRVF
       790        800        810        820        830        840
LMDPVIFTVA HLEDKNHFNA NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN
       850        860        870        880        890        900
FAVLMAHREI YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC
       910        920        930        940        950        960
INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL LLVEVFESEY
       970        980        990       1000       1010       1020
SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD NYFIWSFIGP VSFVIVVNLV
      1030       1040       1050       1060       1070       1080
FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA LGAIALLFLL GLTWAFGLLF INKESVVMAY
      1090       1100       1110       1120       1130       1140
LFTTFNAFQG VFIFVFHCAL QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR
      1150       1160       1170       1180       1190       1200
YYTGTQSRIR RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY
      1210       1220       1230       1240       1250       1260
NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN SYSLRSGDFP
      1270       1280       1290       1300       1310       1320
PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA KGPPPPEPPV PPVPGGGGEE
      1330       1340       1350       1360       1370       1380
EAGGPGGADR AEIELLYKAL EEPLLLPRAQ SVLYQSDLDE SESCTAEDGA TSRPLSSPPG
      1390       1400       1410       1420       1430       1440
RDSLYASGAN LRDSPSYPDS SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY
      1450       1460       1470
YQVRRPSHEG YLAAPGLEGP GPDGDGQMQL VTSL         10         20         30         40         50         60
MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC PGSDVIMVEN
        70         80         90        100        110        120
ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT QCVVVAGSDA FPDPCPGTYK
       130        140        150        160        170        180
YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP TSTHESEHQS GAWCKDPLQA GDRIYVMPWI
       190        200        210        220        230        240
PYRTDTLTEY ASWEDYVAAR HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT
       250        260        270        280        290        300
RIKSGETVIN TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL
       310        320        330        340        350        360
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT NANREEPVSL
       370        380        390        400        410        420
TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD PSAGPATSPP LSTTTTARPT
       430        440        450        460        470        480
PLTSTASPAA TTPLRRAPLT THPVGAINQL GPDLPPATAP VPSTRRPPAP NLHVSPELFC
       490        500        510        520        530        540
EPREVRRVQW PATQQGMLVE RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV
       550        560        570        580        590        600
AQKIKSGENA ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG
       610        620        630        640        650        660
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM LLDVLEEGAF
       670        680        690        700        710        720
LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE EYPRKNSIQL SAKTIKQNSR
       730        740        750        760        770        780
NGVVKVVFIL YNNLGLFLST ENATVKLAGE AGPGGPGGAS LVVNSQVIAA SINKESSRVF
       790        800        810        820        830        840
LMDPVIFTVA HLEDKNHFNA NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN
       850        860        870        880        890        900
FAVLMAHREI YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC
       910        920        930        940        950        960
INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL LLVEVFESEY
       970        980        990       1000       1010       1020
SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD NYFIWSFIGP VSFVIVVNLV
      1030       1040       1050       1060       1070       1080
FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA LGAIALLFLL GLTWAFGLLF INKESVVMAY
      1090       1100       1110       1120       1130       1140
LFTTFNAFQG VFIFVFHCAL QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR
      1150       1160       1170       1180       1190       1200
YYTGTQSRIR RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY
      1210       1220       1230       1240       1250       1260
NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN SYSLRSGDFP
      1270       1280       1290       1300       1310       1320
PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA KGPPPPEPPV PPVPGGGGEE
      1330       1340       1350       1360       1370       1380
EAGGPGGADR AEIELLYKAL EEPLLLPRAQ SVLYQSDLDE SESCTAEDGA TSRPLSSPPG
      1390       1400       1410       1420       1430       1440
RDSLYASGAN LRDSPSYPDS SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY
      1450       1460       1470
YQVRRPSHEG YLAAPGLEGP GPDGDGQMQL VTSL

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O94910-1-unknown	MARLAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79801
O94910-25-unknown	LSRAGL...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O94910-25-unknown	LSRAGL...	25	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
O94910-25-unknown	LSRAGL...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113805
O94910-839-unknown	TNFAVL...	839	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16773
O94910-839-unknown	TNFAVL...	839	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156624

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ACSHLT	838	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16773
...ACSHLT	838	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140109
...LVTSL	1474	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LVTSL	1474	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75419

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
LPHN1-Isoform2_HUMAN	833	SHLT.\|.TNFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16773
AGRL1_HUMAN	838	SHLT.\|.TNFA	inferred from experiment	unknown	MEROPS		Merops LPHN1_HUMAN -> LPHN1_HUMAN @838

TopFIND

O94910: Adhesion G protein-coupled receptor L1 {ECO:0000312|HGNC:HGNC:20973}

General Information

3

N-termini

2

C-termini

1

Cleavages

2

Substrates

Sequence

Isoforms

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Evidence Codes:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 2 Substrates

N-termini

C-termini

Cleavages

Substrates