O95248: Myotubularin-related protein 5
| Protein names | - Myotubularin-related protein 5 - Inactive phosphatidylinositol 3-phosphatase 5 {ECO:0000305} - SET-binding factor 1 - Sbf1 |
|---|---|
| Gene names | SBF1 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | O95248 |
1
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MARLADYFVL VAFGPHPRGS GEGQGQILQR FPEKDWEDNP FPQGIELFCQ PSGWQLCPER
70 80 90 100 110 120
NPPTFFVAVL TDINSERHYC ACLTFWEPAE PSQQETTRVE DATEREEEGD EGGQTHLSPT
130 140 150 160 170 180
APAPSAQLFA PKTLVLVSRL DHTEVFRNSL GLIYAIHVEG LNVCLENVIG NLLTCTVPLA
190 200 210 220 230 240
GGSQRTISLG AGDRQVIQTP LADSLPVSRC SVALLFRQLG ITNVLSLFCA ALTEHKVLFL
250 260 270 280 290 300
SRSYQRLADA CRGLLALLFP LRYSFTYVPI LPAQLLEVLS TPTPFIIGVN AAFQAETQEL
310 320 330 340 350 360
LDVIVADLDG GTVTIPECVH IPPLPEPLQS QTHSVLSMVL DPELELADLA FPPPTTSTSS
370 380 390 400 410 420
LKMQDKELRA VFLRLFAQLL QGYRWCLHVV RIHPEPVIRF HKAAFLGQRG LVEDDFLMKV
430 440 450 460 470 480
LEGMAFAGFV SERGVPYRPT DLFDELVAHE VARMRADENH PQRVLRHVQE LAEQLYKNEN
490 500 510 520 530 540
PYPAVAMHKV QRPGESSHLR RVPRPFPRLD EGTVQWIVDQ AAAKMQGAPP AVKAERRTTV
550 560 570 580 590 600
PSGPPMTAIL ERCSGLHVNS ARRLEVVRNC ISYVFEGKML EAKKLLPAVL RALKGRAARR
610 620 630 640 650 660
CLAQELHLHV QQNRAVLDHQ QFDFVVRMMN CCLQDCTSLD EHGIAAALLP LVTAFCRKLS
670 680 690 700 710 720
PGVTQFAYSC VQEHVVWSTP QFWEAMFYGD VQTHIRALYL EPTEDLAPAQ EVGEAPSQED
730 740 750 760 770 780
ERSALDVASE QRRLWPTLSR EKQQELVQKE ESTVFSQAIH YANRMSYLLL PLDSSKSRLL
790 800 810 820 830 840
RERAGLGDLE SASNSLVTNS MAGSVAESYD TESGFEDAET CDVAGAVVRF INRFVDKVCT
850 860 870 880 890 900
ESGVTSDHLK GLHVMVPDIV QMHIETLEAV QRESRRLPPI QKPKLLRPRL LPGEECVLDG
910 920 930 940 950 960
LRVYLLPDGR EEGAGGSAGG PALLPAEGAV FLTTYRVIFT GMPTDPLVGE QVVVRSFPVA
970 980 990 1000 1010 1020
ALTKEKRISV QTPVDQLLQD GLQLRSCTFQ LLKMAFDEEV GSDSAELFRK QLHKLRYPPD
1030 1040 1050 1060 1070 1080
IRATFAFTLG SAHTPGRPPR VTKDKGPSLR TLSRNLVKNA KKTIGRQHVT RKKYNPPSWE
1090 1100 1110 1120 1130 1140
HRGQPPPEDQ EDEISVSEEL EPSTLTPSSA LKPSDRMTMS SLVERACCRD YQRLGLGTLS
1150 1160 1170 1180 1190 1200
SSLSRAKSEP FRISPVNRMY AICRSYPGLL IVPQSVQDNA LQRVSRCYRQ NRFPVVCWRS
1210 1220 1230 1240 1250 1260
GRSKAVLLRS GGLHGKGVVG LFKAQNAPSP GQSQADSSSL EQEKYLQAVV SSMPRYADAS
1270 1280 1290 1300 1310 1320
GRNTLSGFSS AHMGSHGKWG SVRTSGRSSG LGTDVGSRLA GRDALAPPQA NGGPPDPGFL
1330 1340 1350 1360 1370 1380
RPQRAALYIL GDKAQLKGVR SDPLQQWELV PIEVFEARQV KASFKKLLKA CVPGCPAAEP
1390 1400 1410 1420 1430 1440
SPASFLRSLE DSEWLIQIHK LLQVSVLVVE LLDSGSSVLV GLEDGWDITT QVVSLVQLLS
1450 1460 1470 1480 1490 1500
DPFYRTLEGF RLLVEKEWLS FGHRFSHRGA HTLAGQSSGF TPVFLQFLDC VHQVHLQFPM
1510 1520 1530 1540 1550 1560
EFEFSQFYLK FLGYHHVSRR FRTFLLDSDY ERIELGLLYE EKGERRGQVP CRSVWEYVDR
1570 1580 1590 1600 1610 1620
LSKRTPVFHN YMYAPEDAEV LRPYSNVSNL KVWDFYTEET LAEGPPYDWE LAQGPPEPPE
1630 1640 1650 1660 1670 1680
EERSDGGAPQ SRRRVVWPCY DSCPRAQPDA ISRLLEELQR LETELGQPAE RWKDTWDRVK
1690 1700 1710 1720 1730 1740
AAQRLEGRPD GRGTPSSLLV STAPHHRRSL GVYLQEGPVG STLSLSLDSD QSSGSTTSGS
1750 1760 1770 1780 1790 1800
RQAARRSTST LYSQFQTAES ENRSYEGTLY KKGAFMKPWK ARWFVLDKTK HQLRYYDHRV
1810 1820 1830 1840 1850 1860
DTECKGVIDL AEVEAVAPGT PTMGAPKTVD EKAFFDVKTT RRVYNFCAQD VPSAQQWVDR
IQSCLSDA
Isoforms
- Isoform 4 of Myotubularin-related protein 5 - Isoform 4 of Myotubularin-related protein 5 - Isoform 5 of Myotubularin-related protein 5Sequence View
10 20 30 40 50 60
MARLADYFVL VAFGPHPRGS GEGQGQILQR FPEKDWEDNP FPQGIELFCQ PSGWQLCPER
70 80 90 100 110 120
NPPTFFVAVL TDINSERHYC ACLTFWEPAE PSQQETTRVE DATEREEEGD EGGQTHLSPT
130 140 150 160 170 180
APAPSAQLFA PKTLVLVSRL DHTEVFRNSL GLIYAIHVEG LNVCLENVIG NLLTCTVPLA
190 200 210 220 230 240
GGSQRTISLG AGDRQVIQTP LADSLPVSRC SVALLFRQLG ITNVLSLFCA ALTEHKVLFL
250 260 270 280 290 300
SRSYQRLADA CRGLLALLFP LRYSFTYVPI LPAQLLEVLS TPTPFIIGVN AAFQAETQEL
310 320 330 340 350 360
LDVIVADLDG GTVTIPECVH IPPLPEPLQS QTHSVLSMVL DPELELADLA FPPPTTSTSS
370 380 390 400 410 420
LKMQDKELRA VFLRLFAQLL QGYRWCLHVV RIHPEPVIRF HKAAFLGQRG LVEDDFLMKV
430 440 450 460 470 480
LEGMAFAGFV SERGVPYRPT DLFDELVAHE VARMRADENH PQRVLRHVQE LAEQLYKNEN
490 500 510 520 530 540
PYPAVAMHKV QRPGESSHLR RVPRPFPRLD EGTVQWIVDQ AAAKMQGAPP AVKAERRTTV
550 560 570 580 590 600
PSGPPMTAIL ERCSGLHVNS ARRLEVVRNC ISYVFEGKML EAKKLLPAVL RALKGRAARR
610 620 630 640 650 660
CLAQELHLHV QQNRAVLDHQ QFDFVVRMMN CCLQDCTSLD EHGIAAALLP LVTAFCRKLS
670 680 690 700 710 720
PGVTQFAYSC VQEHVVWSTP QFWEAMFYGD VQTHIRALYL EPTEDLAPAQ EVGEAPSQED
730 740 750 760 770 780
ERSALDVASE QRRLWPTLSR EKQQELVQKE ESTVFSQAIH YANRMSYLLL PLDSSKSRLL
790 800 810 820 830 840
RERAGLGDLE SASNSLVTNS MAGSVAESYD TESGFEDAET CDVAGAVVRF INRFVDKVCT
850 860 870 880 890 900
ESGVTSDHLK GLHVMVPDIV QMHIETLEAV QRESRRLPPI QKPKLLRPRL LPGEECVLDG
910 920 930 940 950 960
LRVYLLPDGR EEGAGGSAGG PALLPAEGAV FLTTYRVIFT GMPTDPLVGE QVVVRSFPVA
970 980 990 1000 1010 1020
ALTKEKRISV QTPVDQLLQD GLQLRSCTFQ LLKMAFDEEV GSDSAELFRK QLHKLRYPPD
1030 1040 1050 1060 1070 1080
IRATFAFTLG SAHTPGRPPR VTKDKGPSLR TLSRNLVKNA KKTIGRQHVT RKKYNPPSWE
1090 1100 1110 1120 1130 1140
HRGQPPPEDQ EDEISVSEEL EPSTLTPSSA LKPSDRMTMS SLVERACCRD YQRLGLGTLS
1150 1160 1170 1180 1190 1200
SSLSRAKSEP FRISPVNRMY AICRSYPGLL IVPQSVQDNA LQRVSRCYRQ NRFPVVCWRS
1210 1220 1230 1240 1250 1260
GRSKAVLLRS GGLHGKGVVG LFKAQNAPSP GQSQADSSSL EQEKYLQAVV SSMPRYADAS
1270 1280 1290 1300 1310 1320
GRNTLSGFSS AHMGSHGKWG SVRTSGRSSG LGTDVGSRLA GRDALAPPQA NGGPPDPGFL
1330 1340 1350 1360 1370 1380
RPQRAALYIL GDKAQLKGVR SDPLQQWELV PIEVFEARQV KASFKKLLKA CVPGCPAAEP
1390 1400 1410 1420 1430 1440
SPASFLRSLE DSEWLIQIHK LLQVSVLVVE LLDSGSSVLV GLEDGWDITT QVVSLVQLLS
1450 1460 1470 1480 1490 1500
DPFYRTLEGF RLLVEKEWLS FGHRFSHRGA HTLAGQSSGF TPVFLQFLDC VHQVHLQFPM
1510 1520 1530 1540 1550 1560
EFEFSQFYLK FLGYHHVSRR FRTFLLDSDY ERIELGLLYE EKGERRGQVP CRSVWEYVDR
1570 1580 1590 1600 1610 1620
LSKRTPVFHN YMYAPEDAEV LRPYSNVSNL KVWDFYTEET LAEGPPYDWE LAQGPPEPPE
1630 1640 1650 1660 1670 1680
EERSDGGAPQ SRRRVVWPCY DSCPRAQPDA ISRLLEELQR LETELGQPAE RWKDTWDRVK
1690 1700 1710 1720 1730 1740
AAQRLEGRPD GRGTPSSLLV STAPHHRRSL GVYLQEGPVG STLSLSLDSD QSSGSTTSGS
1750 1760 1770 1780 1790 1800
RQAARRSTST LYSQFQTAES ENRSYEGTLY KKGAFMKPWK ARWFVLDKTK HQLRYYDHRV
1810 1820 1830 1840 1850 1860
DTECKGVIDL AEVEAVAPGT PTMGAPKTVD EKAFFDVKTT RRVYNFCAQD VPSAQQWVDR
IQSCLSDA
10 20 30 40 50 60
MARLADYFVL VAFGPHPRGS GEGQGQILQR FPEKDWEDNP FPQGIELFCQ PSGWQLCPER
70 80 90 100 110 120
NPPTFFVAVL TDINSERHYC ACLTFWEPAE PSQQETTRVE DATEREEEGD EGGQTHLSPT
130 140 150 160 170 180
APAPSAQLFA PKTLVLVSRL DHTEVFRNSL GLIYAIHVEG LNVCLENVIG NLLTCTVPLA
190 200 210 220 230 240
GGSQRTISLG AGDRQVIQTP LADSLPVSRC SVALLFRQLG ITNVLSLFCA ALTEHKVLFL
250 260 270 280 290 300
SRSYQRLADA CRGLLALLFP LRYSFTYVPI LPAQLLEVLS TPTPFIIGVN AAFQAETQEL
310 320 330 340 350 360
LDVIVADLDG GTVTIPECVH IPPLPEPLQS QTHSVLSMVL DPELELADLA FPPPTTSTSS
370 380 390 400 410 420
LKMQDKELRA VFLRLFAQLL QGYRWCLHVV RIHPEPVIRF HKAAFLGQRG LVEDDFLMKV
430 440 450 460 470 480
LEGMAFAGFV SERGVPYRPT DLFDELVAHE VARMRADENH PQRVLRHVQE LAEQLYKNEN
490 500 510 520 530 540
PYPAVAMHKV QRPGESSHLR RVPRPFPRLD EGTVQWIVDQ AAAKMQGAPP AVKAERRTTV
550 560 570 580 590 600
PSGPPMTAIL ERCSGLHVNS ARRLEVVRNC ISYVFEGKML EAKKLLPAVL RALKGRAARR
610 620 630 640 650 660
CLAQELHLHV QQNRAVLDHQ QFDFVVRMMN CCLQDCTSLD EHGIAAALLP LVTAFCRKLS
670 680 690 700 710 720
PGVTQFAYSC VQEHVVWSTP QFWEAMFYGD VQTHIRALYL EPTEDLAPAQ EVGEAPSQED
730 740 750 760 770 780
ERSALDVASE QRRLWPTLSR EKQQELVQKE ESTVFSQAIH YANRMSYLLL PLDSSKSRLL
790 800 810 820 830 840
RERAGLGDLE SASNSLVTNS MAGSVAESYD TESGFEDAET CDVAGAVVRF INRFVDKVCT
850 860 870 880 890 900
ESGVTSDHLK GLHVMVPDIV QMHIETLEAV QRESRRLPPI QKPKLLRPRL LPGEECVLDG
910 920 930 940 950 960
LRVYLLPDGR EEGAGGSAGG PALLPAEGAV FLTTYRVIFT GMPTDPLVGE QVVVRSFPVA
970 980 990 1000 1010 1020
ALTKEKRISV QTPVDQLLQD GLQLRSCTFQ LLKMAFDEEV GSDSAELFRK QLHKLRYPPD
1030 1040 1050 1060 1070 1080
IRATFAFTLG SAHTPGRPPR VTKDKGPSLR TLSRNLVKNA KKTIGRQHVT RKKYNPPSWE
1090 1100 1110 1120 1130 1140
HRGQPPPEDQ EDEISVSEEL EPSTLTPSSA LKPSDRMTMS SLVERACCRD YQRLGLGTLS
1150 1160 1170 1180 1190 1200
SSLSRAKSEP FRISPVNRMY AICRSYPGLL IVPQSVQDNA LQRVSRCYRQ NRFPVVCWRS
1210 1220 1230 1240 1250 1260
GRSKAVLLRS GGLHGKGVVG LFKAQNAPSP GQSQADSSSL EQEKYLQAVV SSMPRYADAS
1270 1280 1290 1300 1310 1320
GRNTLSGFSS AHMGSHGKWG SVRTSGRSSG LGTDVGSRLA GRDALAPPQA NGGPPDPGFL
1330 1340 1350 1360 1370 1380
RPQRAALYIL GDKAQLKGVR SDPLQQWELV PIEVFEARQV KASFKKLLKA CVPGCPAAEP
1390 1400 1410 1420 1430 1440
SPASFLRSLE DSEWLIQIHK LLQVSVLVVE LLDSGSSVLV GLEDGWDITT QVVSLVQLLS
1450 1460 1470 1480 1490 1500
DPFYRTLEGF RLLVEKEWLS FGHRFSHRGA HTLAGQSSGF TPVFLQFLDC VHQVHLQFPM
1510 1520 1530 1540 1550 1560
EFEFSQFYLK FLGYHHVSRR FRTFLLDSDY ERIELGLLYE EKGERRGQVP CRSVWEYVDR
1570 1580 1590 1600 1610 1620
LSKRTPVFHN YMYAPEDAEV LRPYSNVSNL KVWDFYTEET LAEGPPYDWE LAQGPPEPPE
1630 1640 1650 1660 1670 1680
EERSDGGAPQ SRRRVVWPCY DSCPRAQPDA ISRLLEELQR LETELGQPAE RWKDTWDRVK
1690 1700 1710 1720 1730 1740
AAQRLEGRPD GRGTPSSLLV STAPHHRRSL GVYLQEGPVG STLSLSLDSD QSSGSTTSGS
1750 1760 1770 1780 1790 1800
RQAARRSTST LYSQFQTAES ENRSYEGTLY KKGAFMKPWK ARWFVLDKTK HQLRYYDHRV
1810 1820 1830 1840 1850 1860
DTECKGVIDL AEVEAVAPGT PTMGAPKTVD EKAFFDVKTT RRVYNFCAQD VPSAQQWVDR
IQSCLSDA
10 20 30 40 50 60
MARLADYFVL VAFGPHPRGS GEGQGQILQR FPEKDWEDNP FPQGIELFCQ PSGWQLCPER
70 80 90 100 110 120
NPPTFFVAVL TDINSERHYC ACLTFWEPAE PSQQETTRVE DATEREEEGD EGGQTHLSPT
130 140 150 160 170 180
APAPSAQLFA PKTLVLVSRL DHTEVFRNSL GLIYAIHVEG LNVCLENVIG NLLTCTVPLA
190 200 210 220 230 240
GGSQRTISLG AGDRQVIQTP LADSLPVSRC SVALLFRQLG ITNVLSLFCA ALTEHKVLFL
250 260 270 280 290 300
SRSYQRLADA CRGLLALLFP LRYSFTYVPI LPAQLLEVLS TPTPFIIGVN AAFQAETQEL
310 320 330 340 350 360
LDVIVADLDG GTVTIPECVH IPPLPEPLQS QTHSVLSMVL DPELELADLA FPPPTTSTSS
370 380 390 400 410 420
LKMQDKELRA VFLRLFAQLL QGYRWCLHVV RIHPEPVIRF HKAAFLGQRG LVEDDFLMKV
430 440 450 460 470 480
LEGMAFAGFV SERGVPYRPT DLFDELVAHE VARMRADENH PQRVLRHVQE LAEQLYKNEN
490 500 510 520 530 540
PYPAVAMHKV QRPGESSHLR RVPRPFPRLD EGTVQWIVDQ AAAKMQGAPP AVKAERRTTV
550 560 570 580 590 600
PSGPPMTAIL ERCSGLHVNS ARRLEVVRNC ISYVFEGKML EAKKLLPAVL RALKGRAARR
610 620 630 640 650 660
CLAQELHLHV QQNRAVLDHQ QFDFVVRMMN CCLQDCTSLD EHGIAAALLP LVTAFCRKLS
670 680 690 700 710 720
PGVTQFAYSC VQEHVVWSTP QFWEAMFYGD VQTHIRALYL EPTEDLAPAQ EVGEAPSQED
730 740 750 760 770 780
ERSALDVASE QRRLWPTLSR EKQQELVQKE ESTVFSQAIH YANRMSYLLL PLDSSKSRLL
790 800 810 820 830 840
RERAGLGDLE SASNSLVTNS MAGSVAESYD TESGFEDAET CDVAGAVVRF INRFVDKVCT
850 860 870 880 890 900
ESGVTSDHLK GLHVMVPDIV QMHIETLEAV QRESRRLPPI QKPKLLRPRL LPGEECVLDG
910 920 930 940 950 960
LRVYLLPDGR EEGAGGSAGG PALLPAEGAV FLTTYRVIFT GMPTDPLVGE QVVVRSFPVA
970 980 990 1000 1010 1020
ALTKEKRISV QTPVDQLLQD GLQLRSCTFQ LLKMAFDEEV GSDSAELFRK QLHKLRYPPD
1030 1040 1050 1060 1070 1080
IRATFAFTLG SAHTPGRPPR VTKDKGPSLR TLSRNLVKNA KKTIGRQHVT RKKYNPPSWE
1090 1100 1110 1120 1130 1140
HRGQPPPEDQ EDEISVSEEL EPSTLTPSSA LKPSDRMTMS SLVERACCRD YQRLGLGTLS
1150 1160 1170 1180 1190 1200
SSLSRAKSEP FRISPVNRMY AICRSYPGLL IVPQSVQDNA LQRVSRCYRQ NRFPVVCWRS
1210 1220 1230 1240 1250 1260
GRSKAVLLRS GGLHGKGVVG LFKAQNAPSP GQSQADSSSL EQEKYLQAVV SSMPRYADAS
1270 1280 1290 1300 1310 1320
GRNTLSGFSS AHMGSHGKWG SVRTSGRSSG LGTDVGSRLA GRDALAPPQA NGGPPDPGFL
1330 1340 1350 1360 1370 1380
RPQRAALYIL GDKAQLKGVR SDPLQQWELV PIEVFEARQV KASFKKLLKA CVPGCPAAEP
1390 1400 1410 1420 1430 1440
SPASFLRSLE DSEWLIQIHK LLQVSVLVVE LLDSGSSVLV GLEDGWDITT QVVSLVQLLS
1450 1460 1470 1480 1490 1500
DPFYRTLEGF RLLVEKEWLS FGHRFSHRGA HTLAGQSSGF TPVFLQFLDC VHQVHLQFPM
1510 1520 1530 1540 1550 1560
EFEFSQFYLK FLGYHHVSRR FRTFLLDSDY ERIELGLLYE EKGERRGQVP CRSVWEYVDR
1570 1580 1590 1600 1610 1620
LSKRTPVFHN YMYAPEDAEV LRPYSNVSNL KVWDFYTEET LAEGPPYDWE LAQGPPEPPE
1630 1640 1650 1660 1670 1680
EERSDGGAPQ SRRRVVWPCY DSCPRAQPDA ISRLLEELQR LETELGQPAE RWKDTWDRVK
1690 1700 1710 1720 1730 1740
AAQRLEGRPD GRGTPSSLLV STAPHHRRSL GVYLQEGPVG STLSLSLDSD QSSGSTTSGS
1750 1760 1770 1780 1790 1800
RQAARRSTST LYSQFQTAES ENRSYEGTLY KKGAFMKPWK ARWFVLDKTK HQLRYYDHRV
1810 1820 1830 1840 1850 1860
DTECKGVIDL AEVEAVAPGT PTMGAPKTVD EKAFFDVKTT RRVYNFCAQD VPSAQQWVDR
IQSCLSDA
Protein Neighborhood
Domains & Features
1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| O95248-1-unknown | MARLAD... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O95248-1-unknown | MARLAD... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81753 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...SCLSDA | 1867 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...SCLSDA | 1867 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77371 | |||
| ...SCLSDA | 1867 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
| ...SCLSDA | 1867 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|