O95453: Poly(A)-specific ribonuclease PARN

General Information

Protein names	- Poly(A)-specific ribonuclease PARN - 3.1.13.4 - Deadenylating nuclease - Deadenylation nuclease - Polyadenylate-specific ribonuclease
Gene names	PARN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95453

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEIIRSNFKS NLHKVYQAIE EADFFAIDGE FSGISDGPSV SALTNGFDTP EERYQKLKKH
        70         80         90        100        110        120
SMDFLLFQFG LCTFKYDYTD SKYITKSFNF YVFPKPFNRS SPDVKFVCQS SSIDFLASQG
       130        140        150        160        170        180
FDFNKVFRNG IPYLNQEEER QLREQYDEKR SQANGAGALS YVSPNTSKCP VTIPEDQKKF
       190        200        210        220        230        240
IDQVVEKIED LLQSEENKNL DLEPCTGFQR KLIYQTLSWK YPKGIHVETL ETEKKERYIV
       250        260        270        280        290        300
ISKVDEEERK RREQQKHAKE QEELNDAVGF SRVIHAIANS GKLVIGHNML LDVMHTVHQF
       310        320        330        340        350        360
YCPLPADLSE FKEMTTCVFP RLLDTKLMAS TQPFKDIINN TSLAELEKRL KETPFNPPKV
       370        380        390        400        410        420
ESAEGFPSYD TASEQLHEAG YDAYITGLCF ISMANYLGSF LSPPKIHVSA RSKLIEPFFN
       430        440        450        460        470        480
KLFLMRVMDI PYLNLEGPDL QPKRDHVLHV TFPKEWKTSD LYQLFSAFGN IQISWIDDTS
       490        500        510        520        530        540
AFVSLSQPEQ VKIAVNTSKY AESYRIQTYA EYMGRKQEEK QIKRKWTEDS WKEADSKRLN
       550        560        570        580        590        600
PQCIPYTLQN HYYRNNSFTA PSTVGKRNLS PSQEEAGLED GVSGEISDTE LEQTDSCAEP
       610        620        630
LSEGRKKAKK LKRMKKELSP AGSISKNSPA TLFEVPDTW

Isoforms

- Isoform 2 of Poly(A)-specific ribonuclease PARN - Isoform 3 of Poly(A)-specific ribonuclease PARN - Isoform 4 of Poly(A)-specific ribonuclease PARN

Sequence View

        10         20         30         40         50         60
MEIIRSNFKS NLHKVYQAIE EADFFAIDGE FSGISDGPSV SALTNGFDTP EERYQKLKKH
        70         80         90        100        110        120
SMDFLLFQFG LCTFKYDYTD SKYITKSFNF YVFPKPFNRS SPDVKFVCQS SSIDFLASQG
       130        140        150        160        170        180
FDFNKVFRNG IPYLNQEEER QLREQYDEKR SQANGAGALS YVSPNTSKCP VTIPEDQKKF
       190        200        210        220        230        240
IDQVVEKIED LLQSEENKNL DLEPCTGFQR KLIYQTLSWK YPKGIHVETL ETEKKERYIV
       250        260        270        280        290        300
ISKVDEEERK RREQQKHAKE QEELNDAVGF SRVIHAIANS GKLVIGHNML LDVMHTVHQF
       310        320        330        340        350        360
YCPLPADLSE FKEMTTCVFP RLLDTKLMAS TQPFKDIINN TSLAELEKRL KETPFNPPKV
       370        380        390        400        410        420
ESAEGFPSYD TASEQLHEAG YDAYITGLCF ISMANYLGSF LSPPKIHVSA RSKLIEPFFN
       430        440        450        460        470        480
KLFLMRVMDI PYLNLEGPDL QPKRDHVLHV TFPKEWKTSD LYQLFSAFGN IQISWIDDTS
       490        500        510        520        530        540
AFVSLSQPEQ VKIAVNTSKY AESYRIQTYA EYMGRKQEEK QIKRKWTEDS WKEADSKRLN
       550        560        570        580        590        600
PQCIPYTLQN HYYRNNSFTA PSTVGKRNLS PSQEEAGLED GVSGEISDTE LEQTDSCAEP
       610        620        630
LSEGRKKAKK LKRMKKELSP AGSISKNSPA TLFEVPDTW         10         20         30         40         50         60
MEIIRSNFKS NLHKVYQAIE EADFFAIDGE FSGISDGPSV SALTNGFDTP EERYQKLKKH
        70         80         90        100        110        120
SMDFLLFQFG LCTFKYDYTD SKYITKSFNF YVFPKPFNRS SPDVKFVCQS SSIDFLASQG
       130        140        150        160        170        180
FDFNKVFRNG IPYLNQEEER QLREQYDEKR SQANGAGALS YVSPNTSKCP VTIPEDQKKF
       190        200        210        220        230        240
IDQVVEKIED LLQSEENKNL DLEPCTGFQR KLIYQTLSWK YPKGIHVETL ETEKKERYIV
       250        260        270        280        290        300
ISKVDEEERK RREQQKHAKE QEELNDAVGF SRVIHAIANS GKLVIGHNML LDVMHTVHQF
       310        320        330        340        350        360
YCPLPADLSE FKEMTTCVFP RLLDTKLMAS TQPFKDIINN TSLAELEKRL KETPFNPPKV
       370        380        390        400        410        420
ESAEGFPSYD TASEQLHEAG YDAYITGLCF ISMANYLGSF LSPPKIHVSA RSKLIEPFFN
       430        440        450        460        470        480
KLFLMRVMDI PYLNLEGPDL QPKRDHVLHV TFPKEWKTSD LYQLFSAFGN IQISWIDDTS
       490        500        510        520        530        540
AFVSLSQPEQ VKIAVNTSKY AESYRIQTYA EYMGRKQEEK QIKRKWTEDS WKEADSKRLN
       550        560        570        580        590        600
PQCIPYTLQN HYYRNNSFTA PSTVGKRNLS PSQEEAGLED GVSGEISDTE LEQTDSCAEP
       610        620        630
LSEGRKKAKK LKRMKKELSP AGSISKNSPA TLFEVPDTW         10         20         30         40         50         60
MEIIRSNFKS NLHKVYQAIE EADFFAIDGE FSGISDGPSV SALTNGFDTP EERYQKLKKH
        70         80         90        100        110        120
SMDFLLFQFG LCTFKYDYTD SKYITKSFNF YVFPKPFNRS SPDVKFVCQS SSIDFLASQG
       130        140        150        160        170        180
FDFNKVFRNG IPYLNQEEER QLREQYDEKR SQANGAGALS YVSPNTSKCP VTIPEDQKKF
       190        200        210        220        230        240
IDQVVEKIED LLQSEENKNL DLEPCTGFQR KLIYQTLSWK YPKGIHVETL ETEKKERYIV
       250        260        270        280        290        300
ISKVDEEERK RREQQKHAKE QEELNDAVGF SRVIHAIANS GKLVIGHNML LDVMHTVHQF
       310        320        330        340        350        360
YCPLPADLSE FKEMTTCVFP RLLDTKLMAS TQPFKDIINN TSLAELEKRL KETPFNPPKV
       370        380        390        400        410        420
ESAEGFPSYD TASEQLHEAG YDAYITGLCF ISMANYLGSF LSPPKIHVSA RSKLIEPFFN
       430        440        450        460        470        480
KLFLMRVMDI PYLNLEGPDL QPKRDHVLHV TFPKEWKTSD LYQLFSAFGN IQISWIDDTS
       490        500        510        520        530        540
AFVSLSQPEQ VKIAVNTSKY AESYRIQTYA EYMGRKQEEK QIKRKWTEDS WKEADSKRLN
       550        560        570        580        590        600
PQCIPYTLQN HYYRNNSFTA PSTVGKRNLS PSQEEAGLED GVSGEISDTE LEQTDSCAEP
       610        620        630
LSEGRKKAKK LKRMKKELSP AGSISKNSPA TLFEVPDTW

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95453-1-unknown	MEIIRS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95453-1-unknown	MEIIRS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84322
O95453-1-acetylation	MEIIRS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O95453-1-acetylation	MEIIRS...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163203
O95453-62-unknown	MDFLLF...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84321

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VPDTW	639	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VPDTW	639	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79939
...VPDTW	639	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79940

TopFIND

O95453: Poly(A)-specific ribonuclease PARN

General Information

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates