TopFIND 4.0

O95470: Sphingosine-1-phosphate lyase 1 {ECO:0000305}

General Information

Protein names
- Sphingosine-1-phosphate lyase 1 {ECO:0000305}
- S1PL {ECO:0000305}
- SP-lyase 1 {ECO:0000305}
- SPL 1 {ECO:0000305}
- hSPL
- 4.1.2.27 {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:22784711, ECO:0000269|PubMed:24809814, ECO:0000269|PubMed:28165339}
- Sphingosine-1-phosphate aldolase
Gene names SGPL1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O95470

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPSTDLLMLK AFEPYLEILE VYSTKAKNYV NGHCTKYEPW QLIAWSVVWT LLIVWGYEFV 
        70         80         90        100        110        120 
FQPESLWSRF KKKCFKLTRK MPIIGRKIQD KLNKTKDDIS KNMSFLKVDK EYVKALPSQG 
       130        140        150        160        170        180 
LSSSAVLEKL KEYSSMDAFW QEGRASGTVY SGEEKLTELL VKAYGDFAWS NPLHPDIFPG 
       190        200        210        220        230        240 
LRKIEAEIVR IACSLFNGGP DSCGCVTSGG TESILMACKA YRDLAFEKGI KTPEIVAPQS 
       250        260        270        280        290        300 
AHAAFNKAAS YFGMKIVRVP LTKMMEVDVR AMRRAISRNT AMLVCSTPQF PHGVIDPVPE 
       310        320        330        340        350        360 
VAKLAVKYKI PLHVDACLGG FLIVFMEKAG YPLEHPFDFR VKGVTSISAD THKYGYAPKG 
       370        380        390        400        410        420 
SSLVLYSDKK YRNYQFFVDT DWQGGIYASP TIAGSRPGGI SAACWAALMH FGENGYVEAT 
       430        440        450        460        470        480 
KQIIKTARFL KSELENIKGI FVFGNPQLSV IALGSRDFDI YRLSNLMTAK GWNLNQLQFP 
       490        500        510        520        530        540 
PSIHFCITLL HARKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ TTVDRNMVAE 
       550        560    
LSSVFLDSLY STDTVTQGSQ MNGSPKPH

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SPKPH 568 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)