O95864: Acyl-CoA 6-desaturase {ECO:0000305|PubMed:12713571}

General Information

Protein names	- Acyl-CoA 6-desaturase {ECO:0000305\|PubMed:12713571} - 1.14.19.3 {ECO:0000269\|PubMed:12713571} - Delta(6) fatty acid desaturase - D6D {ECO:0000250\|UniProtKB:Q9Z0R9} - Delta(6) desaturase - Delta-6 desaturase {ECO:0000303\|PubMed:12713571, ECO:0000303\|PubMed:9867867} - Fatty acid desaturase 2 {ECO:0000303\|PubMed:10860662}
Gene names	FADS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95864

4 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Fatty acid desaturase 2 - Isoform 3 of Fatty acid desaturase 2 - Isoform 4 of Fatty acid desaturase 2 - Isoform 2 of Acyl-CoA 6-desaturase - Isoform 3 of Acyl-CoA 6-desaturase - Isoform 4 of Acyl-CoA 6-desaturase

Sequence View

        10         20         30         40         50         60
MGKGGNQGEG AAEREVSVPT FSWEEIQKHN LRTDRWLVID RKVYNITKWS IQHPGGQRVI
        70         80         90        100        110        120
GHYAGEDATD AFRAFHPDLE FVGKFLKPLL IGELAPEEPS QDHGKNSKIT EDFRALRKTA
       130        140        150        160        170        180
EDMNLFKTNH VFFLLLLAHI IALESIAWFT VFYFGNGWIP TLITAFVLAT SQAQAGWLQH
       190        200        210        220        230        240
DYGHLSVYRK PKWNHLVHKF VIGHLKGASA NWWNHRHFQH HAKPNIFHKD PDVNMLHVFV
       250        260        270        280        290        300
LGEWQPIEYG KKKLKYLPYN HQHEYFFLIG PPLLIPMYFQ YQIIMTMIVH KNWVDLAWAV
       310        320        330        340        350        360
SYYIRFFITY IPFYGILGAL LFLNFIRFLE SHWFVWVTQM NHIVMEIDQE AYRDWFSSQL
       370        380        390        400        410        420
TATCNVEQSF FNDWFSGHLN FQIEHHLFPT MPRHNLHKIA PLVKSLCAKH GIEYQEKPLL
       430        440
RALLDIIRSL KKSGKLWLDA YLHK         10         20         30         40         50         60
MGKGGNQGEG AAEREVSVPT FSWEEIQKHN LRTDRWLVID RKVYNITKWS IQHPGGQRVI
        70         80         90        100        110        120
GHYAGEDATD AFRAFHPDLE FVGKFLKPLL IGELAPEEPS QDHGKNSKIT EDFRALRKTA
       130        140        150        160        170        180
EDMNLFKTNH VFFLLLLAHI IALESIAWFT VFYFGNGWIP TLITAFVLAT SQAQAGWLQH
       190        200        210        220        230        240
DYGHLSVYRK PKWNHLVHKF VIGHLKGASA NWWNHRHFQH HAKPNIFHKD PDVNMLHVFV
       250        260        270        280        290        300
LGEWQPIEYG KKKLKYLPYN HQHEYFFLIG PPLLIPMYFQ YQIIMTMIVH KNWVDLAWAV
       310        320        330        340        350        360
SYYIRFFITY IPFYGILGAL LFLNFIRFLE SHWFVWVTQM NHIVMEIDQE AYRDWFSSQL
       370        380        390        400        410        420
TATCNVEQSF FNDWFSGHLN FQIEHHLFPT MPRHNLHKIA PLVKSLCAKH GIEYQEKPLL
       430        440
RALLDIIRSL KKSGKLWLDA YLHK         10         20         30         40         50         60
MGKGGNQGEG AAEREVSVPT FSWEEIQKHN LRTDRWLVID RKVYNITKWS IQHPGGQRVI
        70         80         90        100        110        120
GHYAGEDATD AFRAFHPDLE FVGKFLKPLL IGELAPEEPS QDHGKNSKIT EDFRALRKTA
       130        140        150        160        170        180
EDMNLFKTNH VFFLLLLAHI IALESIAWFT VFYFGNGWIP TLITAFVLAT SQAQAGWLQH
       190        200        210        220        230        240
DYGHLSVYRK PKWNHLVHKF VIGHLKGASA NWWNHRHFQH HAKPNIFHKD PDVNMLHVFV
       250        260        270        280        290        300
LGEWQPIEYG KKKLKYLPYN HQHEYFFLIG PPLLIPMYFQ YQIIMTMIVH KNWVDLAWAV
       310        320        330        340        350        360
SYYIRFFITY IPFYGILGAL LFLNFIRFLE SHWFVWVTQM NHIVMEIDQE AYRDWFSSQL
       370        380        390        400        410        420
TATCNVEQSF FNDWFSGHLN FQIEHHLFPT MPRHNLHKIA PLVKSLCAKH GIEYQEKPLL
       430        440
RALLDIIRSL KKSGKLWLDA YLHK         10         20         30         40         50         60
MGKGGNQGEG AAEREVSVPT FSWEEIQKHN LRTDRWLVID RKVYNITKWS IQHPGGQRVI
        70         80         90        100        110        120
GHYAGEDATD AFRAFHPDLE FVGKFLKPLL IGELAPEEPS QDHGKNSKIT EDFRALRKTA
       130        140        150        160        170        180
EDMNLFKTNH VFFLLLLAHI IALESIAWFT VFYFGNGWIP TLITAFVLAT SQAQAGWLQH
       190        200        210        220        230        240
DYGHLSVYRK PKWNHLVHKF VIGHLKGASA NWWNHRHFQH HAKPNIFHKD PDVNMLHVFV
       250        260        270        280        290        300
LGEWQPIEYG KKKLKYLPYN HQHEYFFLIG PPLLIPMYFQ YQIIMTMIVH KNWVDLAWAV
       310        320        330        340        350        360
SYYIRFFITY IPFYGILGAL LFLNFIRFLE SHWFVWVTQM NHIVMEIDQE AYRDWFSSQL
       370        380        390        400        410        420
TATCNVEQSF FNDWFSGHLN FQIEHHLFPT MPRHNLHKIA PLVKSLCAKH GIEYQEKPLL
       430        440
RALLDIIRSL KKSGKLWLDA YLHK         10         20         30         40         50         60
MGKGGNQGEG AAEREVSVPT FSWEEIQKHN LRTDRWLVID RKVYNITKWS IQHPGGQRVI
        70         80         90        100        110        120
GHYAGEDATD AFRAFHPDLE FVGKFLKPLL IGELAPEEPS QDHGKNSKIT EDFRALRKTA
       130        140        150        160        170        180
EDMNLFKTNH VFFLLLLAHI IALESIAWFT VFYFGNGWIP TLITAFVLAT SQAQAGWLQH
       190        200        210        220        230        240
DYGHLSVYRK PKWNHLVHKF VIGHLKGASA NWWNHRHFQH HAKPNIFHKD PDVNMLHVFV
       250        260        270        280        290        300
LGEWQPIEYG KKKLKYLPYN HQHEYFFLIG PPLLIPMYFQ YQIIMTMIVH KNWVDLAWAV
       310        320        330        340        350        360
SYYIRFFITY IPFYGILGAL LFLNFIRFLE SHWFVWVTQM NHIVMEIDQE AYRDWFSSQL
       370        380        390        400        410        420
TATCNVEQSF FNDWFSGHLN FQIEHHLFPT MPRHNLHKIA PLVKSLCAKH GIEYQEKPLL
       430        440
RALLDIIRSL KKSGKLWLDA YLHK         10         20         30         40         50         60
MGKGGNQGEG AAEREVSVPT FSWEEIQKHN LRTDRWLVID RKVYNITKWS IQHPGGQRVI
        70         80         90        100        110        120
GHYAGEDATD AFRAFHPDLE FVGKFLKPLL IGELAPEEPS QDHGKNSKIT EDFRALRKTA
       130        140        150        160        170        180
EDMNLFKTNH VFFLLLLAHI IALESIAWFT VFYFGNGWIP TLITAFVLAT SQAQAGWLQH
       190        200        210        220        230        240
DYGHLSVYRK PKWNHLVHKF VIGHLKGASA NWWNHRHFQH HAKPNIFHKD PDVNMLHVFV
       250        260        270        280        290        300
LGEWQPIEYG KKKLKYLPYN HQHEYFFLIG PPLLIPMYFQ YQIIMTMIVH KNWVDLAWAV
       310        320        330        340        350        360
SYYIRFFITY IPFYGILGAL LFLNFIRFLE SHWFVWVTQM NHIVMEIDQE AYRDWFSSQL
       370        380        390        400        410        420
TATCNVEQSF FNDWFSGHLN FQIEHHLFPT MPRHNLHKIA PLVKSLCAKH GIEYQEKPLL
       430        440
RALLDIIRSL KKSGKLWLDA YLHK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95864-1-unknown	MGKGGN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95864-1-unknown	MGKGGN...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74727
O95864-2-unknown	GKGGNQ...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O95864-2-unknown	GKGGNQ...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178748
O95864-123-unknown	MNLFKT...	123	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430054
O95864-123-unknown	MNLFKT...	123	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430225
O95864-123-unknown	MNLFKT...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131704
O95864-123-unknown	MNLFKT...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131702
O95864-123-unknown	MNLFKT...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131703
O95864-235-unknown	MLHVFV...	235	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443867
O95864-235-unknown	MLHVFV...	235	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437965
O95864-235-unknown	MLHVFV...	235	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131708
O95864-235-unknown	MLHVFV...	235	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131706
O95864-235-unknown	MLHVFV...	235	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131707

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NWWNHR	215	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430225
...NWWNHR	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112359
...NWWNHR	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112357
...NWWNHR	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112358
...HAKPNI	225	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430054
...HAKPNI	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112355
...HAKPNI	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112353
...HAKPNI	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112354
...FQIEHH	385	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437965
...FQIEHH	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112363
...FQIEHH	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112361
...FQIEHH	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112362
...AYLHK	444	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AYLHK	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70346
...AYLHK	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70344

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)