TopFIND 4.0

P00375: Dihydrofolate reductase

General Information

Protein names
- Dihydrofolate reductase
- 1.5.1.3 {ECO:0000269|PubMed:19748785, ECO:0000269|PubMed:25980602}
Gene names Dhfr
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID P00375

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MVRPLNCIVA VSQNMGIGKN GDLPWPPLRN EFKYFQRMTT TSSVEGKQNL VIMGRKTWFS 
        70         80         90        100        110        120 
IPEKNRPLKD RINIVLSREL KEPPRGAHFL AKSLDDALRL IEQPELASKV DMVWIVGGSS 
       130        140        150        160        170        180 
VYQEAMNQPG HLRLFVTRIM QEFESDTFFP EIDLGKYKLL PEYPGVLSEV QEEKGIKYKF 
   
EVYEKKD

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P00375-2-unknown VRPLNC... 2 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P00375-4-unknown PLNCIV... 4 inferred from electronic annotation unknown TISdb inferred from TISdb

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YEKKD 187 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)