P00439: Phenylalanine-4-hydroxylase

General Information

Protein names	- Phenylalanine-4-hydroxylase - PAH - 1.14.16.1 {ECO:0000269\|PubMed:18460651, ECO:0000269\|PubMed:18835579} - Phe-4-monooxygenase
Gene names	PAH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00439

1 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSTAVLENPG LGRKLSDFGQ ETSYIEDNCN QNGAISLIFS LKEEVGALAK VLRLFEENDV
        70         80         90        100        110        120
NLTHIESRPS RLKKDEYEFF THLDKRSLPA LTNIIKILRH DIGATVHELS RDKKKDTVPW
       130        140        150        160        170        180
FPRTIQELDR FANQILSYGA ELDADHPGFK DPVYRARRKQ FADIAYNYRH GQPIPRVEYM
       190        200        210        220        230        240
EEEKKTWGTV FKTLKSLYKT HACYEYNHIF PLLEKYCGFH EDNIPQLEDV SQFLQTCTGF
       250        260        270        280        290        300
RLRPVAGLLS SRDFLGGLAF RVFHCTQYIR HGSKPMYTPE PDICHELLGH VPLFSDRSFA
       310        320        330        340        350        360
QFSQEIGLAS LGAPDEYIEK LATIYWFTVE FGLCKQGDSI KAYGAGLLSS FGELQYCLSE
       370        380        390        400        410        420
KPKLLPLELE KTAIQNYTVT EFQPLYYVAE SFNDAKEKVR NFAATIPRPF SVRYDPYTQR
       430        440        450
IEVLDNTQQL KILADSINSE IGILCSALQK IK

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

1 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P00439-2-unknown	STAVLE...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00439-2-unknown	STAVLE...	2		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KKKDTV	117	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446658
...ANQILS	136	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447620
...LQKIK	452	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)