P00488: Coagulation factor XIII A chain

General Information

Protein names	- Coagulation factor XIII A chain - Coagulation factor XIIIa - 2.3.2.13 {ECO:0000269\|PubMed:27363989} - Protein-glutamine gamma-glutamyltransferase A chain - Transglutaminase A chain
Gene names	F13A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00488

2 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSETSRTAFG GRRAVPPNNS NAAEDDLPTV ELQGVVPRGV NLQEFLNVTS VHLFKERWDT
        70         80         90        100        110        120
NKVDHHTDKY ENNKLIVRRG QSFYVQIDFS RPYDPRRDLF RVEYVIGRYP QENKGTYIPV
       130        140        150        160        170        180
PIVSELQSGK WGAKIVMRED RSVRLSIQSS PKCIVGKFRM YVAVWTPYGV LRTSRNPETD
       190        200        210        220        230        240
TYILFNPWCE DDAVYLDNEK EREEYVLNDI GVIFYGEVND IKTRSWSYGQ FEDGILDTCL
       250        260        270        280        290        300
YVMDRAQMDL SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNIYAYGVPP SAWTGSVDIL
       310        320        330        340        350        360
LEYRSSENPV RYGQCWVFAG VFNTFLRCLG IPARIVTNYF SAHDNDANLQ MDIFLEEDGN
       370        380        390        400        410        420
VNSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP QENSDGMYRC GPASVQAIKH
       430        440        450        460        470        480
GHVCFQFDAP FVFAEVNSDL IYITAKKDGT HVVENVDATH IGKLIVTKQI GGDGMMDITD
       490        500        510        520        530        540
TYKFQEGQEE ERLALETALM YGAKKPLNTE GVMKSRSNVD MDFEVENAVL GKDFKLSITF
       550        560        570        580        590        600
RNNSHNRYTI TAYLSANITF YTGVPKAEFK KETFDVTLEP LSFKKEAVLI QAGEYMGQLL
       610        620        630        640        650        660
EQASLHFFVT ARINETRDVL AKQKSTVLTI PEIIIKVRGT QVVGSDMTVT VQFTNPLKET
       670        680        690        700        710        720
LRNVWVHLDG PGVTRPMKKM FREIRPNSTV QWEEVCRPWV SGHRKLIASM SSDSLRHVYG
       730
ELDVQIQRRP SM

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P00488-2-unknown	MSETSR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00488-39-unknown	GVNLQE...	39	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00488-39-unknown	GVNLQE...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16244
P00488-39-unknown	GVNLQE...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31722

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVVPRG	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16244
...GVVPRG	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31722
...QSGKWG	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416295
...KIVMRE	138	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413334
...RRPSM	732	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	38	VPRG.\|.GVNL	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
THRB_HUMAN	38	VPRG.\|.GVNL	inferred from experiment	unknown	MEROPS	Grant PJ	Ariens RA et al.:The factor XIII V34L polymorphi... (S01.217)	10910914,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)