P01258: Calcitonin

General Information

Protein names	- Calcitonin - Calcitonin - Katacalcin - Calcitonin carboxyl-terminal peptide - CCP - PDN-21
Gene names	CALCA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01258

6 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Calcitonin - Isoform 2 of Calcitonin

Sequence View

        10         20         30         40         50         60
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQDYVQ
        70         80         90        100        110        120
MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF NKFHTFPQTA IGVGAPGKKR
       130        140
DMSSDLERDH RPHVSMPQNA N         10         20         30         40         50         60
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQDYVQ
        70         80         90        100        110        120
MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF NKFHTFPQTA IGVGAPGKKR
       130        140
DMSSDLERDH RPHVSMPQNA N

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01258-1-unknown	MGFQKF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69191
P01258-26-unknown	APFRSA...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01258-26-unknown	APFRSA...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113937
P01258-85-unknown	CGNLST...	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16256
P01258-85-unknown	CGNLST...	85	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141578
P01258-92-unknown	MLGTYT...	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27652
P01258-92-unknown	MLGTYT...	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141917
P01258-95-unknown	TYTQDF...	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27654
P01258-95-unknown	TYTQDF...	95	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142102
P01258-103-unknown	FHTFPQ...	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27656
P01258-103-unknown	FHTFPQ...	103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142526

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRSKRC	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16256
...PRSKRC	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124755
...NLSTCM	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27652
...NLSTCM	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125097
...TCMLGT	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27654
...TCMLGT	94	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125287
...QDFNKF	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27656
...QDFNKF	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125721

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	84	SKRC.\|.CGNL	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
PREP_HUMAN	91	STCM.\|.MLGT	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
PREP_HUMAN	94	MLGT.\|.TYTQ	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
PREP_HUMAN	102	FNKF.\|.FHTF	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)