P02774: Vitamin D-binding protein

General Information

Protein names	- Vitamin D-binding protein - DBP - VDB - Gc protein-derived macrophage activating factor {ECO:0000303\|PubMed:16302727} - Gc-MAF - GcMAF {ECO:0000303\|PubMed:16302727} - Gc-globulin - Group-specific component - Gc {ECO:0000303\|PubMed:16302727} - Vitamin D-binding protein-macrophage activating factor - DBP-maf
Gene names	GC
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02774

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Vitamin D-binding protein - Isoform 3 of Vitamin D-binding protein - Isoform 2 of Vitamin D-binding protein - Isoform 3 of Vitamin D-binding protein

Sequence View

        10         20         30         40         50         60
MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV
        70         80         90        100        110        120
SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK
       130        140        150        160        170        180
LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK
       190        200        210        220        230        240
SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA
       250        260        270        280        290        300
QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC
       310        320        330        340        350        360
QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF
       370        380        390        400        410        420
LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK
       430        440        450        460        470
KLAERLKAKL PDATPTELAK LVNKHSDFAS NCCSINSPPL YCDSEIDAEL KNIL         10         20         30         40         50         60
MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV
        70         80         90        100        110        120
SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK
       130        140        150        160        170        180
LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK
       190        200        210        220        230        240
SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA
       250        260        270        280        290        300
QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC
       310        320        330        340        350        360
QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF
       370        380        390        400        410        420
LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK
       430        440        450        460        470
KLAERLKAKL PDATPTELAK LVNKHSDFAS NCCSINSPPL YCDSEIDAEL KNIL         10         20         30         40         50         60
MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV
        70         80         90        100        110        120
SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK
       130        140        150        160        170        180
LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK
       190        200        210        220        230        240
SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA
       250        260        270        280        290        300
QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC
       310        320        330        340        350        360
QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF
       370        380        390        400        410        420
LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK
       430        440        450        460        470
KLAERLKAKL PDATPTELAK LVNKHSDFAS NCCSINSPPL YCDSEIDAEL KNIL         10         20         30         40         50         60
MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV
        70         80         90        100        110        120
SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK
       130        140        150        160        170        180
LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK
       190        200        210        220        230        240
SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA
       250        260        270        280        290        300
QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC
       310        320        330        340        350        360
QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF
       370        380        390        400        410        420
LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK
       430        440        450        460        470
KLAERLKAKL PDATPTELAK LVNKHSDFAS NCCSINSPPL YCDSEIDAEL KNIL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P02774-1-unknown	MKRVLV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt130672
P02774-17-unknown	LERGRD...	17	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02774-17-unknown	LERGRD...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111893
P02774-123-unknown	MAALKH...	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94330
P02774-123-unknown	MAALKH...	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102855

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NDEICE	145	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426718
...NDEICE	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110214
...NDEICE	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110215
...LKNIL	474	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LKNIL	474	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89948
...LKNIL	474	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89949

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)