TopFIND 4.0

P04278: Sex hormone-binding globulin

General Information

Protein names
- Sex hormone-binding globulin
- SHBG
- Sex steroid-binding protein
- SBP
- Testis-specific androgen-binding protein
- ABP
- Testosterone-estradiol-binding globulin
- TeBG
- Testosterone-estrogen-binding globulin
Gene names SHBG
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P04278

4

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT 
        70         80         90        100        110        120 
FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA 
       130        140        150        160        170        180 
GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS 
       190        200        210        220        230        240 
NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI 
       250        260        270        280        290        300 
PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL 
       310        320        330        340        350        360 
VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS 
       370        380        390        400    
FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH

Isoforms

- Isoform 2 of Sex hormone-binding globulin - Isoform 3 of Sex hormone-binding globulin - Isoform 4 of Sex hormone-binding globulin - Isoform 5 of Sex hormone-binding globulin

Sequence View

        10         20         30         40         50         60 
MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT 
        70         80         90        100        110        120 
FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA 
       130        140        150        160        170        180 
GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS 
       190        200        210        220        230        240 
NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI 
       250        260        270        280        290        300 
PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL 
       310        320        330        340        350        360 
VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS 
       370        380        390        400    
FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH         10         20         30         40         50         60 
MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT 
        70         80         90        100        110        120 
FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA 
       130        140        150        160        170        180 
GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS 
       190        200        210        220        230        240 
NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI 
       250        260        270        280        290        300 
PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL 
       310        320        330        340        350        360 
VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS 
       370        380        390        400    
FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH         10         20         30         40         50         60 
MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT 
        70         80         90        100        110        120 
FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA 
       130        140        150        160        170        180 
GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS 
       190        200        210        220        230        240 
NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI 
       250        260        270        280        290        300 
PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL 
       310        320        330        340        350        360 
VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS 
       370        380        390        400    
FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH         10         20         30         40         50         60 
MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT 
        70         80         90        100        110        120 
FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA 
       130        140        150        160        170        180 
GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS 
       190        200        210        220        230        240 
NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI 
       250        260        270        280        290        300 
PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL 
       310        320        330        340        350        360 
VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS 
       370        380        390        400    
FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH



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Evidence Names:


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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)