P04424: Argininosuccinate lyase

General Information

Protein names	- Argininosuccinate lyase - ASAL - 4.3.2.1 - Arginosuccinase
Gene names	ASL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04424

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Argininosuccinate lyase - Isoform 3 of Argininosuccinate lyase

Sequence View

        10         20         30         40         50         60
MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM
        70         80         90        100        110        120
DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD
       130        140        150        160        170        180
LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL
       190        200        210        220        230        240
TRDSERLLEV RKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA
       250        260        270        280        290        300
EFLFWASLCM THLSRMAEDL ILYCTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA
       310        320        330        340        350        360
GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI STLQIHQENM
       370        380        390        400        410        420
GQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNQLSL QELQTISPLF
       430        440        450        460
SGDVICVWDY GHSVEQYGAL GGTARSSVDW QIRQVRALLQ AQQA         10         20         30         40         50         60
MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM
        70         80         90        100        110        120
DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD
       130        140        150        160        170        180
LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL
       190        200        210        220        230        240
TRDSERLLEV RKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA
       250        260        270        280        290        300
EFLFWASLCM THLSRMAEDL ILYCTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA
       310        320        330        340        350        360
GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI STLQIHQENM
       370        380        390        400        410        420
GQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNQLSL QELQTISPLF
       430        440        450        460
SGDVICVWDY GHSVEQYGAL GGTARSSVDW QIRQVRALLQ AQQA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04424-1-unknown	MASESG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67473
P04424-1-unknown	MASESG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67474
P04424-2-unknown	MASESG...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P04424-2-unknown	MASESG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04424-2-Acetylation	ASESGK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04424-2-Acetylation	ASESGK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P04424-2-Acetylation	ASESGK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111509
P04424-2-Acetylation	ASESGK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111510
P04424-2-Acetylation	ASESGK...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QAQQA	464	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QAQQA	464	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt63092
...QAQQA	464	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt63091
...QAQQA	464		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QAQQA	464		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...QAQQA	464		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QAQQA	464		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)