P04441: H-2 class II histocompatibility antigen gamma chain

General Information

Protein names	- H-2 class II histocompatibility antigen gamma chain - Ia antigen-associated invariant chain - Ii - MHC class II-associated invariant chain - CD74
Gene names	Cd74
Organism	Mus musculus
Protease Family
Protease ID	I31.002
Chromosome location
UniProt ID	P04441

2 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDDQRDLISN HEQLPILGNR PREPERCSRG ALYTGVSVLV ALLLAGQATT AYFLYQQQGR
        70         80         90        100        110        120
LDKLTITSQN LQLESLRMKL PKSAKPVSQM RMATPLLMRP MSMDNMLLGP VKNVTKYGNM
       130        140        150        160        170        180
TQDHVMHLLT RSGPLEYPQL KGTFPENLKH LKNSMDGVNW KIFESWMKQW LLFEMSKNSL
       190        200        210        220        230        240
EEKKPTEAPP KVLTKCQEEV SHIPAVYPGA FRPKCDENGN YLPLQCHGST GYCWCVFPNG
       250        260        270
TEVPHTKSRG RHNCSEPLDM EDLSSGLGVT RQELGQVTL

Isoforms

- Isoform Short of H-2 class II histocompatibility antigen gamma chain

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P04441-1-unknown	MDDQRD...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P04441-1-unknown	MDDQRD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76955
P04441-87-unknown	VSQMRM...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31400
P04441-87-unknown	VSQMRM...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31424
P04441-87-unknown	VSQMRM...	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141672

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KSAKPV	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31400
...KSAKPV	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31424
...KSAKPV	86	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124854
...GQVTL	279	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GQVTL	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72573

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATF_MOUSE	86	AKPV.\|.VSQM	inferred from experiment	unknown	MEROPS	Chapman HA	Shi GP et al.:Role for cathepsin F in invaria... (C01.018)	10748235,
CATS_MOUSE	86	AKPV.\|.VSQM	inferred from experiment	unknown	MEROPS	Ploegh HL	Villadangos JA et al.:Degradation of mouse invariant ... (C01.034)	9254653,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)