P04626: Receptor tyrosine-protein kinase erbB-2

General Information

Protein names	- Receptor tyrosine-protein kinase erbB-2 - 2.7.10.1 - Metastatic lymph node gene 19 protein - MLN 19 - Proto-oncogene Neu - Proto-oncogene c-ErbB-2 - Tyrosine kinase-type cell surface receptor HER2 - p185erbB2 - CD340
Gene names	ERBB2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04626

8 N-termini

5 C-termini

8 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Receptor tyrosine-protein kinase erbB-2 - Isoform 3 of Receptor tyrosine-protein kinase erbB-2 - Isoform 4 of Receptor tyrosine-protein kinase erbB-2 - Isoform 5 of Receptor tyrosine-protein kinase erbB-2 - Isoform 6 of Receptor tyrosine-protein kinase erbB-2

Sequence View

        10         20         30         40         50         60
MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
        70         80         90        100        110        120
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG
       130        140        150        160        170        180
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
       190        200        210        220        230        240
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC
       250        260        270        280        290        300
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP
       310        320        330        340        350        360
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN
       370        380        390        400        410        420
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP
       430        440        450        460        470        480
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
       490        500        510        520        530        540
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC
       550        560        570        580        590        600
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC
       610        620        630        640        650        660
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG
       670        680        690        700        710        720
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL
       730        740        750        760        770        780
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP
       790        800        810        820        830        840
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR
       850        860        870        880        890        900
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT
       910        920        930        940        950        960
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM
       970        980        990       1000       1010       1020
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA
      1030       1040       1050       1060       1070       1080
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG
      1090       1100       1110       1120       1130       1140
AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV
      1150       1160       1170       1180       1190       1200
NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ
      1210       1220       1230       1240       1250
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV         10         20         30         40         50         60
MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
        70         80         90        100        110        120
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG
       130        140        150        160        170        180
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
       190        200        210        220        230        240
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC
       250        260        270        280        290        300
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP
       310        320        330        340        350        360
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN
       370        380        390        400        410        420
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP
       430        440        450        460        470        480
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
       490        500        510        520        530        540
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC
       550        560        570        580        590        600
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC
       610        620        630        640        650        660
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG
       670        680        690        700        710        720
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL
       730        740        750        760        770        780
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP
       790        800        810        820        830        840
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR
       850        860        870        880        890        900
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT
       910        920        930        940        950        960
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM
       970        980        990       1000       1010       1020
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA
      1030       1040       1050       1060       1070       1080
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG
      1090       1100       1110       1120       1130       1140
AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV
      1150       1160       1170       1180       1190       1200
NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ
      1210       1220       1230       1240       1250
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV         10         20         30         40         50         60
MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
        70         80         90        100        110        120
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG
       130        140        150        160        170        180
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
       190        200        210        220        230        240
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC
       250        260        270        280        290        300
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP
       310        320        330        340        350        360
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN
       370        380        390        400        410        420
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP
       430        440        450        460        470        480
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
       490        500        510        520        530        540
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC
       550        560        570        580        590        600
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC
       610        620        630        640        650        660
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG
       670        680        690        700        710        720
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL
       730        740        750        760        770        780
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP
       790        800        810        820        830        840
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR
       850        860        870        880        890        900
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT
       910        920        930        940        950        960
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM
       970        980        990       1000       1010       1020
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA
      1030       1040       1050       1060       1070       1080
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG
      1090       1100       1110       1120       1130       1140
AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV
      1150       1160       1170       1180       1190       1200
NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ
      1210       1220       1230       1240       1250
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV         10         20         30         40         50         60
MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
        70         80         90        100        110        120
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG
       130        140        150        160        170        180
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
       190        200        210        220        230        240
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC
       250        260        270        280        290        300
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP
       310        320        330        340        350        360
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN
       370        380        390        400        410        420
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP
       430        440        450        460        470        480
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
       490        500        510        520        530        540
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC
       550        560        570        580        590        600
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC
       610        620        630        640        650        660
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG
       670        680        690        700        710        720
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL
       730        740        750        760        770        780
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP
       790        800        810        820        830        840
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR
       850        860        870        880        890        900
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT
       910        920        930        940        950        960
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM
       970        980        990       1000       1010       1020
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA
      1030       1040       1050       1060       1070       1080
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG
      1090       1100       1110       1120       1130       1140
AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV
      1150       1160       1170       1180       1190       1200
NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ
      1210       1220       1230       1240       1250
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV         10         20         30         40         50         60
MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
        70         80         90        100        110        120
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG
       130        140        150        160        170        180
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
       190        200        210        220        230        240
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC
       250        260        270        280        290        300
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP
       310        320        330        340        350        360
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN
       370        380        390        400        410        420
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP
       430        440        450        460        470        480
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
       490        500        510        520        530        540
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC
       550        560        570        580        590        600
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC
       610        620        630        640        650        660
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG
       670        680        690        700        710        720
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL
       730        740        750        760        770        780
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP
       790        800        810        820        830        840
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR
       850        860        870        880        890        900
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT
       910        920        930        940        950        960
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM
       970        980        990       1000       1010       1020
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA
      1030       1040       1050       1060       1070       1080
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG
      1090       1100       1110       1120       1130       1140
AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV
      1150       1160       1170       1180       1190       1200
NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ
      1210       1220       1230       1240       1250
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P04626-23-unknown	TQVCTG...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P04626-31-unknown	MKLRLP...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74093
P04626-31-unknown	MKLRLP...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102057
P04626-611-unknown	MPIWKF...	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74090
P04626-611-unknown	MPIWKF...	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101922
P04626-611-unknown	MPIWKF...	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101923
P04626-687-unknown	MRRLLQ...	687	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74091
P04626-687-unknown	MRRLLQ...	687	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101969
P04626-687-unknown	MRRLLQ...	687	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101967
P04626-687-unknown	MRRLLQ...	687	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101968
P04626-1017-unknown	LVDAEE...	1017	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3008
P04626-1017-unknown	LVDAEE...	1017	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1520
P04626-1017-unknown	LVDAEE...	1017	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150555
P04626-1017-unknown	LVDAEE...	1017	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152119
P04626-1017-unknown	LVDAEE...	1017	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157126
P04626-1017-unknown	LVDAEE...	1017	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157158
P04626-1020-unknown	AEEYLV...	1020	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3013
P04626-1020-unknown	AEEYLV...	1020	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1525
P04626-1020-unknown	AEEYLV...	1020	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150604
P04626-1020-unknown	AEEYLV...	1020	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152164
P04626-1020-unknown	AEEYLV...	1020	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157133
P04626-1020-unknown	AEEYLV...	1020	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157161
P04626-1088-unknown	GDLGMG...	1088	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3018
P04626-1088-unknown	GDLGMG...	1088	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1530
P04626-1088-unknown	GDLGMG...	1088	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152028
P04626-1088-unknown	GDLGMG...	1088	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153164
P04626-1088-unknown	GDLGMG...	1088	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157278
P04626-1088-unknown	GDLGMG...	1088	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157312
P04626-1126-unknown	GYVAPL...	1126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3023
P04626-1126-unknown	GYVAPL...	1126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1535
P04626-1126-unknown	GYVAPL...	1126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152631
P04626-1126-unknown	GYVAPL...	1126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153595
P04626-1126-unknown	GYVAPL...	1126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157362
P04626-1126-unknown	GYVAPL...	1126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157419

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDMGDL	1016	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3008
...DDMGDL	1016	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1520
...DDMGDL	1016	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133952
...DDMGDL	1016	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135528
...DDMGDL	1016	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140626
...DDMGDL	1016	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140659
...GDLVDA	1019	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3013
...GDLVDA	1019	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1525
...GDLVDA	1019	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134002
...GDLVDA	1019	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135574
...GDLVDA	1019	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140633
...GDLVDA	1019	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140662
...SDVFDG	1087	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3018
...SDVFDG	1087	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1530
...SDVFDG	1087	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135438
...SDVFDG	1087	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136590
...SDVFDG	1087	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140777
...SDVFDG	1087	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140811
...PSETDG	1125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3023
...PSETDG	1125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1535
...PSETDG	1125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136048
...PSETDG	1125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137018
...PSETDG	1125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140861
...PSETDG	1125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140917
...LDVPV	1255	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LDVPV	1255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69709
...LDVPV	1255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69708
...LDVPV	1255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69711
...LDVPV	1255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69710

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	1016	MGDL.\|.LVDA	inferred from experiment	unknown	MEROPS	Cryns VL	Strohecker AM et al.:Caspase cleavage of HER-2 relea... (C14.003)	18420586,
CASP3_HUMAN	1016	MGDL.\|.LVDA	inferred from experiment	unknown	MEROPS	Cryns VL	Strohecker AM et al.:Caspase cleavage of HER-2 relea... (C14.003)	18420586,
CASP8_HUMAN	1019	LVDA.\|.AEEY	inferred from experiment	unknown	MEROPS	Cryns VL	Strohecker AM et al.:Caspase cleavage of HER-2 relea... (C14.003)	18420586,
CASP3_HUMAN	1019	LVDA.\|.AEEY	inferred from experiment	unknown	MEROPS	Cryns VL	Strohecker AM et al.:Caspase cleavage of HER-2 relea... (C14.003)	18420586,
CASP8_HUMAN	1087	VFDG.\|.GDLG	inferred from experiment	unknown	MEROPS	Cryns VL	Strohecker AM et al.:Caspase cleavage of HER-2 relea... (C14.003)	18420586,
CASP3_HUMAN	1087	VFDG.\|.GDLG	inferred from experiment	unknown	MEROPS	Cryns VL	Strohecker AM et al.:Caspase cleavage of HER-2 relea... (C14.003)	18420586,
CASP8_HUMAN	1125	ETDG.\|.GYVA	inferred from experiment	unknown	MEROPS	Cryns VL	Strohecker AM et al.:Caspase cleavage of HER-2 relea... (C14.003)	18420586,
CASP3_HUMAN	1125	ETDG.\|.GYVA	inferred from experiment	unknown	MEROPS	Cryns VL	Strohecker AM et al.:Caspase cleavage of HER-2 relea... (C14.003)	18420586,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)