TopFIND 4.0

P05108: Cholesterol side-chain cleavage enzyme, mitochondrial

General Information

Protein names
- Cholesterol side-chain cleavage enzyme, mitochondrial
- 1.14.15.6
- CYPXIA1
- Cholesterol desmolase
- Cytochrome P450 11A1
- Cytochrome P450(scc)
Gene names CYP11A1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P05108

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLAKGLPPRS VLVKGCQTFL SAPREGLGRL RVPTGEGAGI STRSPRPFNE IPSPGDNGWL 
        70         80         90        100        110        120 
NLYHFWRETG THKVHLHHVQ NFQKYGPIYR EKLGNVESVY VIDPEDVALL FKSEGPNPER 
       130        140        150        160        170        180 
FLIPPWVAYH QYYQRPIGVL LKKSAAWKKD RVALNQEVMA PEATKNFLPL LDAVSRDFVS 
       190        200        210        220        230        240 
VLHRRIKKAG SGNYSGDISD DLFRFAFESI TNVIFGERQG MLEEVVNPEA QRFIDAIYQM 
       250        260        270        280        290        300 
FHTSVPMLNL PPDLFRLFRT KTWKDHVAAW DVIFSKADIY TQNFYWELRQ KGSVHHDYRG 
       310        320        330        340        350        360 
ILYRLLGDSK MSFEDIKANV TEMLAGGVDT TSMTLQWHLY EMARNLKVQD MLRAEVLAAR 
       370        380        390        400        410        420 
HQAQGDMATM LQLVPLLKAS IKETLRLHPI SVTLQRYLVN DLVLRDYMIP AKTLVQVAIY 
       430        440        450        460        470        480 
ALGREPTFFF DPENFDPTRW LSKDKNITYF RNLGFGWGVR QCLGRRIAEL EMTIFLINML 
       490        500        510        520    
ENFRVEIQHL SDVGTTFNLI LMPEKPISFT FWPFNQEATQ Q

Isoforms

- Isoform 2 of Cholesterol side-chain cleavage enzyme, mitochondrial

Sequence View

        10         20         30         40         50         60 
MLAKGLPPRS VLVKGCQTFL SAPREGLGRL RVPTGEGAGI STRSPRPFNE IPSPGDNGWL 
        70         80         90        100        110        120 
NLYHFWRETG THKVHLHHVQ NFQKYGPIYR EKLGNVESVY VIDPEDVALL FKSEGPNPER 
       130        140        150        160        170        180 
FLIPPWVAYH QYYQRPIGVL LKKSAAWKKD RVALNQEVMA PEATKNFLPL LDAVSRDFVS 
       190        200        210        220        230        240 
VLHRRIKKAG SGNYSGDISD DLFRFAFESI TNVIFGERQG MLEEVVNPEA QRFIDAIYQM 
       250        260        270        280        290        300 
FHTSVPMLNL PPDLFRLFRT KTWKDHVAAW DVIFSKADIY TQNFYWELRQ KGSVHHDYRG 
       310        320        330        340        350        360 
ILYRLLGDSK MSFEDIKANV TEMLAGGVDT TSMTLQWHLY EMARNLKVQD MLRAEVLAAR 
       370        380        390        400        410        420 
HQAQGDMATM LQLVPLLKAS IKETLRLHPI SVTLQRYLVN DLVLRDYMIP AKTLVQVAIY 
       430        440        450        460        470        480 
ALGREPTFFF DPENFDPTRW LSKDKNITYF RNLGFGWGVR QCLGRRIAEL EMTIFLINML 
       490        500        510        520    
ENFRVEIQHL SDVGTTFNLI LMPEKPISFT FWPFNQEATQ Q



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Evidence Codes:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P05108-40-unknown ISTRSP... 40 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P05108-159-unknown MAPEAT... 159 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt71501

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EATQQ 521 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EATQQ 521 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt67119

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)