TopFIND 4.0

P05186: Alkaline phosphatase, tissue-nonspecific isozyme

General Information

Protein names
- Alkaline phosphatase, tissue-nonspecific isozyme
- AP-TNAP
- TNSALP
- 3.1.3.1 {ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064}
- Alkaline phosphatase liver/bone/kidney isozyme
Gene names ALPL
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P05186

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MISPFLVLAI GTCLTNSLVP EKEKDPKYWR DQAQETLKYA LELQKLNTNV AKNVIMFLGD 
        70         80         90        100        110        120 
GMGVSTVTAA RILKGQLHHN PGEETRLEMD KFPFVALSKT YNTNAQVPDS AGTATAYLCG 
       130        140        150        160        170        180 
VKANEGTVGV SAATERSRCN TTQGNEVTSI LRWAKDAGKS VGIVTTTRVN HATPSAAYAH 
       190        200        210        220        230        240 
SADRDWYSDN EMPPEALSQG CKDIAYQLMH NIRDIDVIMG GGRKYMYPKN KTDVEYESDE 
       250        260        270        280        290        300 
KARGTRLDGL DLVDTWKSFK PRYKHSHFIW NRTELLTLDP HNVDYLLGLF EPGDMQYELN 
       310        320        330        340        350        360 
RNNVTDPSLS EMVVVAIQIL RKNPKGFFLL VEGGRIDHGH HEGKAKQALH EAVEMDRAIG 
       370        380        390        400        410        420 
QAGSLTSSED TLTVVTADHS HVFTFGGYTP RGNSIFGLAP MLSDTDKKPF TAILYGNGPG 
       430        440        450        460        470        480 
YKVVGGEREN VSMVDYAHNN YQAQSAVPLR HETHGGEDVA VFSKGPMAHL LHGVHEQNYV 
       490        500        510        520    
PHVMAYAACI GANLGHCAPA SSAGSLAAGP LLLALALYPL SVLF

Isoforms

- Isoform 2 of Alkaline phosphatase, tissue-nonspecific isozyme - Isoform 3 of Alkaline phosphatase, tissue-nonspecific isozyme

Sequence View

        10         20         30         40         50         60 
MISPFLVLAI GTCLTNSLVP EKEKDPKYWR DQAQETLKYA LELQKLNTNV AKNVIMFLGD 
        70         80         90        100        110        120 
GMGVSTVTAA RILKGQLHHN PGEETRLEMD KFPFVALSKT YNTNAQVPDS AGTATAYLCG 
       130        140        150        160        170        180 
VKANEGTVGV SAATERSRCN TTQGNEVTSI LRWAKDAGKS VGIVTTTRVN HATPSAAYAH 
       190        200        210        220        230        240 
SADRDWYSDN EMPPEALSQG CKDIAYQLMH NIRDIDVIMG GGRKYMYPKN KTDVEYESDE 
       250        260        270        280        290        300 
KARGTRLDGL DLVDTWKSFK PRYKHSHFIW NRTELLTLDP HNVDYLLGLF EPGDMQYELN 
       310        320        330        340        350        360 
RNNVTDPSLS EMVVVAIQIL RKNPKGFFLL VEGGRIDHGH HEGKAKQALH EAVEMDRAIG 
       370        380        390        400        410        420 
QAGSLTSSED TLTVVTADHS HVFTFGGYTP RGNSIFGLAP MLSDTDKKPF TAILYGNGPG 
       430        440        450        460        470        480 
YKVVGGEREN VSMVDYAHNN YQAQSAVPLR HETHGGEDVA VFSKGPMAHL LHGVHEQNYV 
       490        500        510        520    
PHVMAYAACI GANLGHCAPA SSAGSLAAGP LLLALALYPL SVLF         10         20         30         40         50         60 
MISPFLVLAI GTCLTNSLVP EKEKDPKYWR DQAQETLKYA LELQKLNTNV AKNVIMFLGD 
        70         80         90        100        110        120 
GMGVSTVTAA RILKGQLHHN PGEETRLEMD KFPFVALSKT YNTNAQVPDS AGTATAYLCG 
       130        140        150        160        170        180 
VKANEGTVGV SAATERSRCN TTQGNEVTSI LRWAKDAGKS VGIVTTTRVN HATPSAAYAH 
       190        200        210        220        230        240 
SADRDWYSDN EMPPEALSQG CKDIAYQLMH NIRDIDVIMG GGRKYMYPKN KTDVEYESDE 
       250        260        270        280        290        300 
KARGTRLDGL DLVDTWKSFK PRYKHSHFIW NRTELLTLDP HNVDYLLGLF EPGDMQYELN 
       310        320        330        340        350        360 
RNNVTDPSLS EMVVVAIQIL RKNPKGFFLL VEGGRIDHGH HEGKAKQALH EAVEMDRAIG 
       370        380        390        400        410        420 
QAGSLTSSED TLTVVTADHS HVFTFGGYTP RGNSIFGLAP MLSDTDKKPF TAILYGNGPG 
       430        440        450        460        470        480 
YKVVGGEREN VSMVDYAHNN YQAQSAVPLR HETHGGEDVA VFSKGPMAHL LHGVHEQNYV 
       490        500        510        520    
PHVMAYAACI GANLGHCAPA SSAGSLAAGP LLLALALYPL SVLF



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P05186-18-unknown LVPEKE... 18 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P05186-56-unknown MFLGDG... 56 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85917

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)