TopFIND 4.0

P06208: 2-isopropylmalate synthase

General Information

Protein names
- 2-isopropylmalate synthase
- 2.3.3.13
- Alpha-IPM synthase
- Alpha-isopropylmalate synthase
Gene names LEU4
Organism Saccharomyces cerevisiae
Protease Family
Protease ID
Chromosome location
UniProt ID P06208

5

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MVKESIIALA EHAASRASRV IPPVKLAYKN MLKDPSSKYK PFNAPKLSNR KWPDNRITRA 
        70         80         90        100        110        120 
PRWLSTDLRD GNQSLPDPMS VEQKKEYFHK LVNIGFKEIE VSFPSASQTD FDFTRYAVEN 
       130        140        150        160        170        180 
APDDVSIQCL VQSREHLIKR TVEALTGAKK ATIHTYLATS DMFREIVFNM SREEAISKAV 
       190        200        210        220        230        240 
EATKLVRKLT KDDPSQQATR WSYEFSPECF SDTPGEFAVE ICEAVKKAWE PTEENPIIFN 
       250        260        270        280        290        300 
LPATVEVASP NVYADQIEYF ATHITEREKV CISTHCHNDR GCGVAATELG MLAGADRVEG 
       310        320        330        340        350        360 
CLFGNGERTG NVDLVTVAMN MYTQGVSPNL DFSDLTSVLD VVERCNKIPV SQRAPYGGDL 
       370        380        390        400        410        420 
VVCAFSGSHQ DAIKKGFNLQ NKKRAQGETQ WRIPYLPLDP KDIGRDYEAV IRVNSQSGKG 
       430        440        450        460        470        480 
GAAWVILRSL GLDLPRNMQI EFSSAVQDHA DSLGRELKSD EISKLFKEAY NYNDEQYQAI 
       490        500        510        520        530        540 
SLVNYNVEKF GTERRVFTGQ VKVGDQIVDI EGTGNGPISS LVDALSNLLN VRFAVANYTE 
       550        560        570        580        590        600 
HSLGSGSSTQ AASYIHLSYR RNADNEKAYK WGVGVSEDVG DSSVRAIFAT INNIIHSGDV 
       610    
SIPSLAEVEG KNAAASGSA

Isoforms

- Isoform Cytoplasmic of 2-isopropylmalate synthase

Sequence View

        10         20         30         40         50         60 
MVKESIIALA EHAASRASRV IPPVKLAYKN MLKDPSSKYK PFNAPKLSNR KWPDNRITRA 
        70         80         90        100        110        120 
PRWLSTDLRD GNQSLPDPMS VEQKKEYFHK LVNIGFKEIE VSFPSASQTD FDFTRYAVEN 
       130        140        150        160        170        180 
APDDVSIQCL VQSREHLIKR TVEALTGAKK ATIHTYLATS DMFREIVFNM SREEAISKAV 
       190        200        210        220        230        240 
EATKLVRKLT KDDPSQQATR WSYEFSPECF SDTPGEFAVE ICEAVKKAWE PTEENPIIFN 
       250        260        270        280        290        300 
LPATVEVASP NVYADQIEYF ATHITEREKV CISTHCHNDR GCGVAATELG MLAGADRVEG 
       310        320        330        340        350        360 
CLFGNGERTG NVDLVTVAMN MYTQGVSPNL DFSDLTSVLD VVERCNKIPV SQRAPYGGDL 
       370        380        390        400        410        420 
VVCAFSGSHQ DAIKKGFNLQ NKKRAQGETQ WRIPYLPLDP KDIGRDYEAV IRVNSQSGKG 
       430        440        450        460        470        480 
GAAWVILRSL GLDLPRNMQI EFSSAVQDHA DSLGRELKSD EISKLFKEAY NYNDEQYQAI 
       490        500        510        520        530        540 
SLVNYNVEKF GTERRVFTGQ VKVGDQIVDI EGTGNGPISS LVDALSNLLN VRFAVANYTE 
       550        560        570        580        590        600 
HSLGSGSSTQ AASYIHLSYR RNADNEKAYK WGVGVSEDVG DSSVRAIFAT INNIIHSGDV 
       610    
SIPSLAEVEG KNAAASGSA



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Evidence Names:


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Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...ASGSA 619 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...ASGSA 619 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt75144

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)