TopFIND 4.0

P06238: Alpha-2-macroglobulin

General Information

Protein names
- Alpha-2-macroglobulin
- Alpha-2-M
Gene names A2m
Organism Rattus norvegicus
Protease Family
Protease ID I39.001
Chromosome location
UniProt ID P06238

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGKHRLRSLA LLPLLLRLLL LLLPTDASAP QKPIYMVMVP SLLHAGTPEK ACFLFSHLNE 
        70         80         90        100        110        120 
TVAVRVSLES VRGNQSLFTD LVVDKDLFHC TSFTVPQSSS DEVMFFTVQV KGATHEFRRR 
       130        140        150        160        170        180 
STVLVKKKES LVFAQTDKPI YKPGQTVRFR VVSLDESFHP LNELIPLLYI QDPKNNRIAQ 
       190        200        210        220        230        240 
WQNFNLEGGL KQLSFPLSSE PTQGSYKVVI RTESGRTVEH PFSVEEFVLP KFEVRVTVPE 
       250        260        270        280        290        300 
TITILEEEMN VSVCGIYTYG KPVPGRVTVN ICRKYSNPSN CFGEESVAFC EKLSQQLDGR 
       310        320        330        340        350        360 
GCFSQLVKTK SFQLKRQEYE MQLDVHAKIQ EEGTGVEETG KGLTKITRTI TKLSFVNVDS 
       370        380        390        400        410        420 
HFRQGIPFVG QVLLVDGRGT PIPYETIFIG ADEANLYINT TTDKHGLARF SINTDDIMGT 
       430        440        450        460        470        480 
SLTVRAKYKD SNACYGFRWL TEENVEAWHT AYAVFSPSRS FLHLESLPDK LRCDQTLEVQ 
       490        500        510        520        530        540 
AHYILNGEAM QELKELVFYY LMMAKGGIVR AGTHVLPLKQ GQMRGHFSIL ISMETDLAPV 
       550        560        570        580        590        600 
ARLVLYAILP NGEVVGDTAK YEIENCLANK VDLVFRPNSG LPATRALLSV MASPQSLCGL 
       610        620        630        640        650        660 
RAVDQSVLLM KPETELSASL IYDLLPVKDL TGFPQGADQR EEDTNGCVKQ NDTYINGILY 
       670        680        690        700        710        720 
SPVQNTNEED MYGFLKDMGL KVFTNSNIRK PKVCERLRDN KGIPAAYHLV SQSHMDAFLE 
       730        740        750        760        770        780 
SSESPTETRR SYFPETWIWD LVVVDSAGVA EVEVTVPDTI TEWKAGAFCL SNDTGLGLSP 
       790        800        810        820        830        840 
VVQFQAFQPF FVELTMPYSV IRGEAFTLKA TVLNYLPTCI RVAVQLEASP DFLAAPEEKE 
       850        860        870        880        890        900 
QRSHCICMNQ RHTASWAVIP KSLGNVNFTV SAEALNSKEL CGNEVPVVPE QGKKDTIIKS 
       910        920        930        940        950        960 
LLVEPEGLEN EVTFNSLLCP MGAEVSELIA LKLPSDVVEE SARASVTVLG DILGSAMQNT 
       970        980        990       1000       1010       1020 
QDLLKMPYGC GEQNMVLFAP NIYVLDYLNE TQQLTQEIKT KAIAYLNTGY QRQLNYKHRD 
      1030       1040       1050       1060       1070       1080 
GSYSTFGDKP GRNHANTWLT AFVLKSFAQA RKYIFIDEVH ITQALLWLSQ QQKDNGCFRS 
      1090       1100       1110       1120       1130       1140 
SGSLLNNAMK GGVEDEVTLS AYITIALLEM SLPVTHPVVR NALFCLDTAW KSARGGAGGS 
      1150       1160       1170       1180       1190       1200 
HVYTKALLAY AFALAGNQDT KKEILKSLDE EAVKEEDSVH WTRPQKPSVS VALWYQPQAP 
      1210       1220       1230       1240       1250       1260 
SAEVEMTAYV LLAYLTTEPA PTQEDLTAAM LIVKWLTKQQ NSHGGFSSTQ DTVVALHALS 
      1270       1280       1290       1300       1310       1320 
KYGSATFTRA KKAAQVTIHS SGTFSTKFQV NNNNQLLLQR VTLPTVPGDY TVKVTGEGCV 
      1330       1340       1350       1360       1370       1380 
YLQTSLKYSV LPREEEFPFT VVVQTLPGTC EDPKAHTSFQ ISLNISYTGS RSESNMAIAD 
      1390       1400       1410       1420       1430       1440 
VKMVSGFIPL KPTVKMLERS VHVSRTEVSN NHVLIYLDKV SNQTVNLSFT VQQDIPIRDL 
      1450       1460       1470    
KPAVVKVYDY YEKDEFAVAK YSAPCSTDYG NA

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P06238-28-unknown SAPQKP... 28 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DYGNA 1472 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)