P07101: Tyrosine 3-monooxygenase

General Information

Protein names	- Tyrosine 3-monooxygenase - 1.14.16.2 - Tyrosine 3-hydroxylase - TH
Gene names	TH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07101

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Tyrosine 3-monooxygenase - Isoform 2 of Tyrosine 3-monooxygenase - Isoform 4 of Tyrosine 3-monooxygenase - Isoform 5 of Tyrosine 3-monooxygenase - Isoform 6 of Tyrosine 3-monooxygenase

Sequence View

        10         20         30         40         50         60
MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM VRGQGAPGPS LTGSPWPGTA APAASYTPTP
        70         80         90        100        110        120
RSPRFIGRRQ SLIEDARKER EAAVAAAAAA VPSEPGDPLE AVAFEEKEGK AVLNLLFSPR
       130        140        150        160        170        180
ATKPSALSRA VKVFETFEAK IHHLETRPAQ RPRAGGPHLE YFVRLEVRRG DLAALLSGVR
       190        200        210        220        230        240
QVSEDVRSPA GPKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI
       250        260        270        280        290        300
AFQYRHGDPI PRVEYTAEEI ATWKEVYTTL KGLYATHACG EHLEAFALLE RFSGYREDNI
       310        320        330        340        350        360
PQLEDVSRFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ CTQYIRHASS PMHSPEPDCC
       370        380        390        400        410        420
HELLGHVPML ADRTFAQFSQ DIGLASLGAS DEEIEKLSTL YWFTVEFGLC KQNGEVKAYG
       430        440        450        460        470        480
AGLLSSYGEL LHCLSEEPEI RAFDPEAAAV QPYQDQTYQS VYFVSESFSD AKDKLRSYAS
       490        500        510        520
RIQRPFSVKF DPYTLAIDVL DSPQAVRRSL EGVQDELDTL AHALSAIG         10         20         30         40         50         60
MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM VRGQGAPGPS LTGSPWPGTA APAASYTPTP
        70         80         90        100        110        120
RSPRFIGRRQ SLIEDARKER EAAVAAAAAA VPSEPGDPLE AVAFEEKEGK AVLNLLFSPR
       130        140        150        160        170        180
ATKPSALSRA VKVFETFEAK IHHLETRPAQ RPRAGGPHLE YFVRLEVRRG DLAALLSGVR
       190        200        210        220        230        240
QVSEDVRSPA GPKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI
       250        260        270        280        290        300
AFQYRHGDPI PRVEYTAEEI ATWKEVYTTL KGLYATHACG EHLEAFALLE RFSGYREDNI
       310        320        330        340        350        360
PQLEDVSRFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ CTQYIRHASS PMHSPEPDCC
       370        380        390        400        410        420
HELLGHVPML ADRTFAQFSQ DIGLASLGAS DEEIEKLSTL YWFTVEFGLC KQNGEVKAYG
       430        440        450        460        470        480
AGLLSSYGEL LHCLSEEPEI RAFDPEAAAV QPYQDQTYQS VYFVSESFSD AKDKLRSYAS
       490        500        510        520
RIQRPFSVKF DPYTLAIDVL DSPQAVRRSL EGVQDELDTL AHALSAIG         10         20         30         40         50         60
MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM VRGQGAPGPS LTGSPWPGTA APAASYTPTP
        70         80         90        100        110        120
RSPRFIGRRQ SLIEDARKER EAAVAAAAAA VPSEPGDPLE AVAFEEKEGK AVLNLLFSPR
       130        140        150        160        170        180
ATKPSALSRA VKVFETFEAK IHHLETRPAQ RPRAGGPHLE YFVRLEVRRG DLAALLSGVR
       190        200        210        220        230        240
QVSEDVRSPA GPKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI
       250        260        270        280        290        300
AFQYRHGDPI PRVEYTAEEI ATWKEVYTTL KGLYATHACG EHLEAFALLE RFSGYREDNI
       310        320        330        340        350        360
PQLEDVSRFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ CTQYIRHASS PMHSPEPDCC
       370        380        390        400        410        420
HELLGHVPML ADRTFAQFSQ DIGLASLGAS DEEIEKLSTL YWFTVEFGLC KQNGEVKAYG
       430        440        450        460        470        480
AGLLSSYGEL LHCLSEEPEI RAFDPEAAAV QPYQDQTYQS VYFVSESFSD AKDKLRSYAS
       490        500        510        520
RIQRPFSVKF DPYTLAIDVL DSPQAVRRSL EGVQDELDTL AHALSAIG         10         20         30         40         50         60
MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM VRGQGAPGPS LTGSPWPGTA APAASYTPTP
        70         80         90        100        110        120
RSPRFIGRRQ SLIEDARKER EAAVAAAAAA VPSEPGDPLE AVAFEEKEGK AVLNLLFSPR
       130        140        150        160        170        180
ATKPSALSRA VKVFETFEAK IHHLETRPAQ RPRAGGPHLE YFVRLEVRRG DLAALLSGVR
       190        200        210        220        230        240
QVSEDVRSPA GPKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI
       250        260        270        280        290        300
AFQYRHGDPI PRVEYTAEEI ATWKEVYTTL KGLYATHACG EHLEAFALLE RFSGYREDNI
       310        320        330        340        350        360
PQLEDVSRFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ CTQYIRHASS PMHSPEPDCC
       370        380        390        400        410        420
HELLGHVPML ADRTFAQFSQ DIGLASLGAS DEEIEKLSTL YWFTVEFGLC KQNGEVKAYG
       430        440        450        460        470        480
AGLLSSYGEL LHCLSEEPEI RAFDPEAAAV QPYQDQTYQS VYFVSESFSD AKDKLRSYAS
       490        500        510        520
RIQRPFSVKF DPYTLAIDVL DSPQAVRRSL EGVQDELDTL AHALSAIG         10         20         30         40         50         60
MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM VRGQGAPGPS LTGSPWPGTA APAASYTPTP
        70         80         90        100        110        120
RSPRFIGRRQ SLIEDARKER EAAVAAAAAA VPSEPGDPLE AVAFEEKEGK AVLNLLFSPR
       130        140        150        160        170        180
ATKPSALSRA VKVFETFEAK IHHLETRPAQ RPRAGGPHLE YFVRLEVRRG DLAALLSGVR
       190        200        210        220        230        240
QVSEDVRSPA GPKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI
       250        260        270        280        290        300
AFQYRHGDPI PRVEYTAEEI ATWKEVYTTL KGLYATHACG EHLEAFALLE RFSGYREDNI
       310        320        330        340        350        360
PQLEDVSRFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ CTQYIRHASS PMHSPEPDCC
       370        380        390        400        410        420
HELLGHVPML ADRTFAQFSQ DIGLASLGAS DEEIEKLSTL YWFTVEFGLC KQNGEVKAYG
       430        440        450        460        470        480
AGLLSSYGEL LHCLSEEPEI RAFDPEAAAV QPYQDQTYQS VYFVSESFSD AKDKLRSYAS
       490        500        510        520
RIQRPFSVKF DPYTLAIDVL DSPQAVRRSL EGVQDELDTL AHALSAIG

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P07101-1-unknown	MPTPDA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93483
P07101-1-unknown	MPTPDA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93484
P07101-1-unknown	MPTPDA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93485
P07101-1-unknown	MPTPDA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93486
P07101-1-unknown	MPTPDA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93487
P07101-1-unknown	MPTPDA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07101-2-unknown	PTPDAT...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07101-2-unknown	PTPDAT...	2	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P07101-2-unknown	PTPDAT...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111628
P07101-2-unknown	PTPDAT...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111629
P07101-2-unknown	PTPDAT...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111630
P07101-2-unknown	PTPDAT...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111631
P07101-2-unknown	PTPDAT...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111632

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LLSSYG	427	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403546
...LLSSYG	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114596
...LLSSYG	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114595
...LLSSYG	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114593
...LLSSYG	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114594
...LLSSYG	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114592
...LSAIG	528	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LSAIG	528	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89105
...LSAIG	528	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89104
...LSAIG	528	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89102
...LSAIG	528	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89103
...LSAIG	528	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89101

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)