P07948: Tyrosine-protein kinase Lyn

General Information

Protein names	- Tyrosine-protein kinase Lyn - 2.7.10.2 - Lck/Yes-related novel protein tyrosine kinase - V-yes-1 Yamaguchi sarcoma viral related oncogene homolog - p53Lyn - p56Lyn
Gene names	LYN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07948

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD
        70         80         90        100        110        120
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK
       130        140        150        160        170        180
LNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI
       190        200        210        220        230        240
KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW
       250        260        270        280        290        300
EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD
       310        320        330        340        350        360
KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER
       370        380        390        400        410        420
KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF
       430        440        450        460        470        480
TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW
       490        500        510
KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP

Isoforms

- Isoform 2 of Tyrosine-protein kinase Lyn

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07948-1-unknown	MGCIKS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80106
P07948-2-unknown	GCIKSK...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07948-2-unknown	GCIKSK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111167
P07948-19-unknown	LKTQPV...	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1598
P07948-38-	SNKQQR...	38		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDGVDL	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1598
...YQQQP	512	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YQQQP	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75724

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	18	GVDL.\|.LKTQ	inferred from experiment	unknown	MEROPS	Auberger P	Luciano F et al.:Cleavage of Fyn and Lyn in thei... (C14.003)	11526478,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)