TopFIND 4.0

P08192: Dihydrofolate synthase/folylpolyglutamate synthase {ECO:0000305}

General Information

Protein names
- Dihydrofolate synthase/folylpolyglutamate synthase {ECO:0000305}
- DHFS / FPGS {ECO:0000303|PubMed:15705579}
- 6.3.2.12 {ECO:0000269|PubMed:18232714, ECO:0000269|PubMed:1989505, ECO:0000269|PubMed:2985605}
- 6.3.2.17 {ECO:0000269|PubMed:18232714}
- Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase {ECO:0000303|PubMed:2985605}
- Folylpolyglutamate synthetase {ECO:0000303|PubMed:18232714}
- Tetrahydrofolylpolyglutamate synthase
Gene names folC
Organism Escherichia coli
Protease Family
Protease ID
Chromosome location
UniProt ID P08192

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MIIKRTPQAA SPLASWLSYL ENLHSKTIDL GLERVSLVAA RLGVLKPAPF VFTVAGTNGK 
        70         80         90        100        110        120 
GTTCRTLESI LMAAGYKVGV YSSPHLVRYT ERVRVQGQEL PESAHTASFA EIESARGDIS 
       130        140        150        160        170        180 
LTYFEYGTLS ALWLFKQAQL DVVILEVGLG GRLDATNIVD ADVAVVTSIA LDHTDWLGPD 
       190        200        210        220        230        240 
RESIGREKAG IFRSEKPAIV GEPEMPSTIA DVAQEKGALL QRRGVEWNYS VTDHDWAFSD 
       250        260        270        280        290        300 
AHGTLENLPL PLVPQPNAAT ALAALRASGL EVSENAIRDG IASAILPGRF QIVSESPRVI 
       310        320        330        340        350        360 
FDVAHNPHAA EYLTGRMKAL PKNGRVLAVI GMLHDKDIAG TLAWLKSVVD DWYCAPLEGP 
       370        380        390        400        410        420 
RGATAEQLLE HLGNGKSFDS VAQAWDAAMA DAKAEDTVLV CGSFHTVAHV MEVIDARRSG 
   
GK

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P08192-1-unknown MIIKRT... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...RSGGK 422 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)