P08243: Asparagine synthetase [glutamine-hydrolyzing]

General Information

Protein names	- Asparagine synthetase glutamine-hydrolyzing] - 6.3.5.4 - Cell cycle control protein TS11 - Glutamine-dependent asparagine synthetase
Gene names	ASNS
Organism	Homo sapiens
Protease Family
Protease ID	C44.974
Chromosome location
UniProt ID	P08243

7 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Asparagine synthetase [glutamine-hydrolyzing] - Isoform 3 of Asparagine synthetase [glutamine-hydrolyzing]

Sequence View

        10         20         30         40         50         60
MCGIWALFGS DDCLSVQCLS AMKIAHRGPD AFRFENVNGY TNCCFGFHRL AVVDPLFGMQ
        70         80         90        100        110        120
PIRVKKYPYL WLCYNGEIYN HKKMQQHFEF EYQTKVDGEI ILHLYDKGGI EQTICMLDGV
       130        140        150        160        170        180
FAFVLLDTAN KKVFLGRDTY GVRPLFKAMT EDGFLAVCSE AKGLVTLKHS ATPFLKVEPF
       190        200        210        220        230        240
LPGHYEVLDL KPNGKVASVE MVKYHHCRDV PLHALYDNVE KLFPGFEIET VKNNLRILFN
       250        260        270        280        290        300
NAVKKRLMTD RRIGCLLSGG LDSSLVAATL LKQLKEAQVQ YPLQTFAIGM EDSPDLLAAR
       310        320        330        340        350        360
KVADHIGSEH YEVLFNSEEG IQALDEVIFS LETYDITTVR ASVGMYLISK YIRKNTDSVV
       370        380        390        400        410        420
IFSGEGSDEL TQGYIYFHKA PSPEKAEEES ERLLRELYLF DVLRADRTTA AHGLELRVPF
       430        440        450        460        470        480
LDHRFSSYYL SLPPEMRIPK NGIEKHLLRE TFEDSNLIPK EILWRPKEAF SDGITSVKNS
       490        500        510        520        530        540
WFKILQEYVE HQVDDAMMAN AAQKFPFNTP KTKEGYYYRQ VFERHYPGRA DWLSHYWMPK
       550        560
WINATDPSAR TLTHYKSAVK A         10         20         30         40         50         60
MCGIWALFGS DDCLSVQCLS AMKIAHRGPD AFRFENVNGY TNCCFGFHRL AVVDPLFGMQ
        70         80         90        100        110        120
PIRVKKYPYL WLCYNGEIYN HKKMQQHFEF EYQTKVDGEI ILHLYDKGGI EQTICMLDGV
       130        140        150        160        170        180
FAFVLLDTAN KKVFLGRDTY GVRPLFKAMT EDGFLAVCSE AKGLVTLKHS ATPFLKVEPF
       190        200        210        220        230        240
LPGHYEVLDL KPNGKVASVE MVKYHHCRDV PLHALYDNVE KLFPGFEIET VKNNLRILFN
       250        260        270        280        290        300
NAVKKRLMTD RRIGCLLSGG LDSSLVAATL LKQLKEAQVQ YPLQTFAIGM EDSPDLLAAR
       310        320        330        340        350        360
KVADHIGSEH YEVLFNSEEG IQALDEVIFS LETYDITTVR ASVGMYLISK YIRKNTDSVV
       370        380        390        400        410        420
IFSGEGSDEL TQGYIYFHKA PSPEKAEEES ERLLRELYLF DVLRADRTTA AHGLELRVPF
       430        440        450        460        470        480
LDHRFSSYYL SLPPEMRIPK NGIEKHLLRE TFEDSNLIPK EILWRPKEAF SDGITSVKNS
       490        500        510        520        530        540
WFKILQEYVE HQVDDAMMAN AAQKFPFNTP KTKEGYYYRQ VFERHYPGRA DWLSHYWMPK
       550        560
WINATDPSAR TLTHYKSAVK A

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08243-2-unknown	CGIWAL...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08243-2-unknown	CGIWAL...	2	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P08243-22-unknown	MKIAHR...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67661
P08243-84-unknown	MQQHFE...	84	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67662
P08243-84-unknown	MQQHFE...	84	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100293
P08243-287-	AIGMED...	287		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08243-287-	AIGMED...	287		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08243-287-	AIGMED...	287		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08243-287-unknown	AIGMED...	287	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168581
P08243-287-unknown	AIGMED...	287	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168582
P08243-551-	TLTHYK...	551		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P08243-551-unknown	TLTHYK...	551	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177325
P08243-551-unknown	TLTHYK...	551	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177326

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SAVKA	561	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SAVKA	561	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63280
...SAVKA	561	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63279

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)