P08572: Collagen alpha-2(IV) chain

General Information

Protein names	- Collagen alpha-2(IV) chain - Canstatin
Gene names	COL4A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08572

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGRDQRAVAG PALRRWLLLG TVTVGFLAQS VLAGVKKFDV PCGGRDCSGG CQCYPEKGGR
        70         80         90        100        110        120
GQPGPVGPQG YNGPPGLQGF PGLQGRKGDK GERGAPGVTG PKGDVGARGV SGFPGADGIP
       130        140        150        160        170        180
GHPGQGGPRG RPGYDGCNGT QGDSGPQGPP GSEGFTGPPG PQGPKGQKGE PYALPKEERD
       190        200        210        220        230        240
RYRGEPGEPG LVGFQGPPGR PGHVGQMGPV GAPGRPGPPG PPGPKGQQGN RGLGFYGVKG
       250        260        270        280        290        300
EKGDVGQPGP NGIPSDTLHP IIAPTGVTFH PDQYKGEKGS EGEPGIRGIS LKGEEGIMGF
       310        320        330        340        350        360
PGLRGYPGLS GEKGSPGQKG SRGLDGYQGP DGPRGPKGEA GDPGPPGLPA YSPHPSLAKG
       370        380        390        400        410        420
ARGDPGFPGA QGEPGSQGEP GDPGLPGPPG LSIGDGDQRR GLPGEMGPKG FIGDPGIPAL
       430        440        450        460        470        480
YGGPPGPDGK RGPPGPPGLP GPPGPDGFLF GLKGAKGRAG FPGLPGSPGA RGPKGWKGDA
       490        500        510        520        530        540
GECRCTEGDE AIKGLPGLPG PKGFAGINGE PGRKGDRGDP GQHGLPGFPG LKGVPGNIGA
       550        560        570        580        590        600
PGPKGAKGDS RTITTKGERG QPGVPGVPGM KGDDGSPGRD GLDGFPGLPG PPGDGIKGPP
       610        620        630        640        650        660
GDPGYPGIPG TKGTPGEMGP PGLGLPGLKG QRGFPGDAGL PGPPGFLGPP GPAGTPGQID
       670        680        690        700        710        720
CDTDVKRAVG GDRQEAIQPG CIGGPKGLPG LPGPPGPTGA KGLRGIPGFA GADGGPGPRG
       730        740        750        760        770        780
LPGDAGREGF PGPPGFIGPR GSKGAVGLPG PDGSPGPIGL PGPDGPPGER GLPGEVLGAQ
       790        800        810        820        830        840
PGPRGDAGVP GQPGLKGLPG DRGPPGFRGS QGMPGMPGLK GQPGLPGPSG QPGLYGPPGL
       850        860        870        880        890        900
HGFPGAPGQE GPLGLPGIPG REGLPGDRGD PGDTGAPGPV GMKGLSGDRG DAGFTGEQGH
       910        920        930        940        950        960
PGSPGFKGID GMPGTPGLKG DRGSPGMDGF QGMPGLKGRP GFPGSKGEAG FFGIPGLKGL
       970        980        990       1000       1010       1020
AGEPGFKGSR GDPGPPGPPP VILPGMKDIK GEKGDEGPMG LKGYLGAKGI QGMPGIPGLS
      1030       1040       1050       1060       1070       1080
GIPGLPGRPG HIKGVKGDIG VPGIPGLPGF PGVAGPPGIT GFPGFIGSRG DKGAPGRAGL
      1090       1100       1110       1120       1130       1140
YGEIGATGDF GDIGDTINLP GRPGLKGERG TTGIPGLKGF FGEKGTEGDI GFPGITGVTG
      1150       1160       1170       1180       1190       1200
VQGPPGLKGQ TGFPGLTGPP GSQGELGRIG LPGGKGDDGW PGAPGLPGFP GLRGIRGLHG
      1210       1220       1230       1240       1250       1260
LPGTKGFPGS PGSDIHGDPG FPGPPGERGD PGEANTLPGP VGVPGQKGDQ GAPGERGPPG
      1270       1280       1290       1300       1310       1320
SPGLQGFPGI TPPSNISGAP GDKGAPGIFG LKGYRGPPGP PGSAALPGSK GDTGNPGAPG
      1330       1340       1350       1360       1370       1380
TPGTKGWAGD SGPQGRPGVF GLPGEKGPRG EQGFMGNTGP TGAVGDRGPK GPKGDPGFPG
      1390       1400       1410       1420       1430       1440
APGTVGAPGI AGIPQKIAVQ PGTVGPQGRR GPPGAPGEMG PQGPPGEPGF RGAPGKAGPQ
      1450       1460       1470       1480       1490       1500
GRGGVSAVPG FRGDEGPIGH QGPIGQEGAP GRPGSPGLPG MPGRSVSIGY LLVKHSQTDQ
      1510       1520       1530       1540       1550       1560
EPMCPVGMNK LWSGYSLLYF EGQEKAHNQD LGLAGSCLAR FSTMPFLYCN PGDVCYYASR
      1570       1580       1590       1600       1610       1620
NDKSYWLSTT APLPMMPVAE DEIKPYISRC SVCEAPAIAI AVHSQDVSIP HCPAGWRSLW
      1630       1640       1650       1660       1670       1680
IGYSFLMHTA AGDEGGGQSL VSPGSCLEDF RATPFIECNG GRGTCHYYAN KYSFWLTTIP
      1690       1700       1710
EQSFQGSPSA DTLKAGLIRT HISRCQVCMK NL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P08572-184-unknown	GEPGEP...	184	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08572-1078-unknown	AGLYGE...	1078	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15985
P08572-1110-unknown	GTTGIP...	1110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15986
P08572-1486-unknown	VSIGYL...	1486	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PKGDVG	105	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000383027
...GAPGRA	1077	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15985
...LKGERG	1109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15986
...CMKNL	1712	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK14_HUMAN	1077	PGRA.\|.AGLY	inferred from experiment	unknown	MEROPS	Diamandis EP	Borgono CA et al.:Expression and functional chara... (S01.029)	17110383,
KLK14_HUMAN	1109	GERG.\|.GTTG	inferred from experiment	unknown	MEROPS	Diamandis EP	Borgono CA et al.:Expression and functional chara... (S01.029)	17110383,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)