P08590: Myosin light chain 3 {ECO:0000305}

General Information

Protein names	- Myosin light chain 3 {ECO:0000305} - Cardiac myosin light chain 1 {ECO:0000303\|Ref.5} - CMLC1 {ECO:0000303\|Ref.5} - Myosin light chain 1, slow-twitch muscle B/ventricular isoform {ECO:0000305} - MLC1SB - Ventricular myosin alkali light chain {ECO:0000303\|PubMed:3417683} - Ventricular myosin light chain 1 {ECO:0000303\|PubMed:3357795} - VLCl {ECO:0000303\|PubMed:3357795} - Ventricular/slow twitch myosin alkali light chain {ECO:0000303\|PubMed:2789520} - MLC-lV/sb {ECO:0000303\|PubMed:2789520}
Gene names	MYL3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08590

2 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPKKPEPKK DDAKAAPKAA PAPAPPPEPE RPKEVEFDAS KIKIEFTPEQ IEEFKEAFML
        70         80         90        100        110        120
FDRTPKCEMK ITYGQCGDVL RALGQNPTQA EVLRVLGKPR QEELNTKMMD FETFLPMLQH
       130        140        150        160        170        180
ISKNKDTGTY EDFVEGLRVF DKEGNGTVMG AELRHVLATL GERLTEDEVE KLMAGQEDSN
       190
GCINYEAFVK HIMSS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P08590-2-unknown	APKKPE...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08590-2-unknown	APKKPE...	2	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P08590-136-unknown	GLRVFD...	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1609

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IKIEFT	46	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393455
...EDFVEG	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1609
...HIMSS	195	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	135	FVEG.\|.GLRV	inferred from experiment	unknown	MEROPS	Laugwitz KL	Moretti A et al.:Essential myosin light chain as... (C14.003)	12186978,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)