P08684: Cytochrome P450 3A4
| Protein names | - Cytochrome P450 3A4 - 1.14.14.- - 1,8-cineole 2-exo-monooxygenase - 1.14.14.56 {ECO:0000269|PubMed:11159812} - Albendazole monooxygenase (sulfoxide-forming) - 1.14.14.73 {ECO:0000269|PubMed:10759686} - Albendazole sulfoxidase - CYPIIIA3 - CYPIIIA4 - Cholesterol 25-hydroxylase {ECO:0000305|PubMed:21576599} - 1.14.14.- {ECO:0000269|PubMed:21576599} - Cytochrome P450 3A3 - Cytochrome P450 HLp - Cytochrome P450 NF-25 - Cytochrome P450-PCN1 - Nifedipine oxidase - Quinine 3-monooxygenase - 1.14.14.55 {ECO:0000269|PubMed:11159812} - Taurochenodeoxycholate 6-alpha-hydroxylase - 1.14.14.- {ECO:0000269|PubMed:11159812} |
|---|---|
| Gene names | CYP3A4 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P08684 |
1
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI LSYHKGFCMF
70 80 90 100 110 120
DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKSAISI
130 140 150 160 170 180
AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKDVFGAYS
190 200 210 220 230 240
MDVITSTSFG VNIDSLNNPQ DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV
250 260 270 280 290 300
FPREVTNFLR KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI
310 320 330 340 350 360
IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV LQMEYLDMVV
370 380 390 400 410 420
NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA LHRDPKYWTE PEKFLPERFS
430 440 450 460 470 480
KKNKDNIDPY IYTPFGSGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLSLG
490 500
GLLQPEKPVV LKVESRDGTV SGA
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P08684-2-unknown | ALIPDL... | 2 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...TFTSGK | 140 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000397208 | |||
| ...TVSGA | 503 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|