P0C0L5: Complement C4-B
| Protein names | - Complement C4-B - Basic complement C4 - C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 - Complement C4 beta chain - Complement C4-B alpha chain - C4a anaphylatoxin - C4b-B - C4d-B - Complement C4 gamma chain |
|---|---|
| Gene names | C4B_2 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | I39.951 |
| Chromosome location | |
| UniProt ID | P0C0L5 |
5
N-termini
5
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MRLLWGLIWA SSFFTLSLQK PRLLLFSPSV VHLGVPLSVG VQLQDVPRGQ VVKGSVFLRN
70 80 90 100 110 120
PSRNNVPCSP KVDFTLSSER DFALLSLQVP LKDAKSCGLH QLLRGPEVQL VAHSPWLKDS
130 140 150 160 170 180
LSRTTNIQGI NLLFSSRRGH LFLQTDQPIY NPGQRVRYRV FALDQKMRPS TDTITVMVEN
190 200 210 220 230 240
SHGLRVRKKE VYMPSSIFQD DFVIPDISEP GTWKISARFS DGLESNSSTQ FEVKKYVLPN
250 260 270 280 290 300
FEVKITPGKP YILTVPGHLD EMQLDIQARY IYGKPVQGVA YVRFGLLDED GKKTFFRGLE
310 320 330 340 350 360
SQTKLVNGQS HISLSKAEFQ DALEKLNMGI TDLQGLRLYV AAAIIESPGG EMEEAELTSW
370 380 390 400 410 420
YFVSSPFSLD LSKTKRHLVP GAPFLLQALV REMSGSPASG IPVKVSATVS SPGSVPEVQD
430 440 450 460 470 480
IQQNTDGSGQ VSIPIIIPQT ISELQLSVSA GSPHPAIARL TVAAPPSGGP GFLSIERPDS
490 500 510 520 530 540
RPPRVGDTLN LNLRAVGSGA TFSHYYYMIL SRGQIVFMNR EPKRTLTSVS VFVDHHLAPS
550 560 570 580 590 600
FYFVAFYYHG DHPVANSLRV DVQAGACEGK LELSVDGAKQ YRNGESVKLH LETDSLALVA
610 620 630 640 650 660
LGALDTALYA AGSKSHKPLN MGKVFEAMNS YDLGCGPGGG DSALQVFQAA GLAFSDGDQW
670 680 690 700 710 720
TLSRKRLSCP KEKTTRKKRN VNFQKAINEK LGQYASPTAK RCCQDGVTRL PMMRSCEQRA
730 740 750 760 770 780
ARVQQPDCRE PFLSCCQFAE SLRKKSRDKG QAGLQRALEI LQEEDLIDED DIPVRSFFPE
790 800 810 820 830 840
NWLWRVETVD RFQILTLWLP DSLTTWEIHG LSLSKTKGLC VATPVQLRVF REFHLHLRLP
850 860 870 880 890 900
MSVRRFEQLE LRPVLYNYLD KNLTVSVHVS PVEGLCLAGG GGLAQQVLVP AGSARPVAFS
910 920 930 940 950 960
VVPTAATAVS LKVVARGSFE FPVGDAVSKV LQIEKEGAIH REELVYELNP LDHRGRTLEI
970 980 990 1000 1010 1020
PGNSDPNMIP DGDFNSYVRV TASDPLDTLG SEGALSPGGV ASLLRLPRGC GEQTMIYLAP
1030 1040 1050 1060 1070 1080
TLAASRYLDK TEQWSTLPPE TKDHAVDLIQ KGYMRIQQFR KADGSYAAWL SRGSSTWLTA
1090 1100 1110 1120 1130 1140
FVLKVLSLAQ EQVGGSPEKL QETSNWLLSQ QQADGSFQDL SPVIHRSMQG GLVGNDETVA
1150 1160 1170 1180 1190 1200
LTAFVTIALH HGLAVFQDEG AEPLKQRVEA SISKASSFLG EKASAGLLGA HAAAITAYAL
1210 1220 1230 1240 1250 1260
TLTKAPADLR GVAHNNLMAM AQETGDNLYW GSVTGSQSNA VSPTPAPRNP SDPMPQAPAL
1270 1280 1290 1300 1310 1320
WIETTAYALL HLLLHEGKAE MADQAAAWLT RQGSFQGGFR STQDTVIALD ALSAYWIASH
1330 1340 1350 1360 1370 1380
TTEERGLNVT LSSTGRNGFK SHALQLNNRQ IRGLEEELQF SLGSKINVKV GGNSKGTLKV
1390 1400 1410 1420 1430 1440
LRTYNVLDMK NTTCQDLQIE VTVKGHVEYT MEANEDYEDY EYDELPAKDD PDAPLQPVTP
1450 1460 1470 1480 1490 1500
LQLFEGRRNR RRREAPKVVE EQESRVHYTV CIWRNGKVGL SGMAIADVTL LSGFHALRAD
1510 1520 1530 1540 1550 1560
LEKLTSLSDR YVSHFETEGP HVLLYFDSVP TSRECVGFEA VQEVPVGLVQ PASATLYDYY
1570 1580 1590 1600 1610 1620
NPERRCSVFY GAPSKSRLLA TLCSAEVCQC AEGKCPRQRR ALERGLQDED GYRMKFACYY
1630 1640 1650 1660 1670 1680
PRVEYGFQVK VLREDSRAAF RLFETKITQV LHFTKDVKAA ANQMRNFLVR ASCRLRLEPG
1690 1700 1710 1720 1730 1740
KEYLIMGLDG ATYDLEGHPQ YLLDSNSWIE EMPSERLCRS TRQRAACAQL NDFLQEYGTQ
GCQV
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
5 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P0C0L5-20-unknown | KPRLLL... | 20 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P0C0L5-680-unknown | NVNFQK... | 680 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P0C0L5-757-unknown | ALEILQ... | 757 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P0C0L5-957-unknown | TLEIPG... | 957 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P0C0L5-1454-unknown | EAPKVV... | 1454 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...KEKTTR | 675 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...AGLQRA | 756 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...SSTGRN | 1336 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...QLFEGR | 1446 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...QGCQV | 1744 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|