TopFIND 4.0

P0C6P5: Rho guanine nucleotide exchange factor 28

General Information

Protein names
- Rho guanine nucleotide exchange factor 28
- 190 kDa guanine nucleotide exchange factor
- p190-RhoGEF
- p190RhoGEF
- Rho guanine nucleotide exchange factor
Gene names Arhgef28
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P0C6P5

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MELSCSEVPL YGQRTVYAKF GKNVYLPEDA EFYFIYDGSH QRHVVIADRV EDNVLQSIIP 
        70         80         90        100        110        120 
GHWLQETVMV SVCLCSEGYS PVTMGSGSVT YVDNMACRLA RLLVTQADRL TPCSHQTLLT 
       130        140        150        160        170        180 
PFALTAEALP ALDEELVLAL TQLELPLGWT VLGNSSLEVC LHRESLLHLA VRWALPKLFH 
       190        200        210        220        230        240 
FLLCLPGGVK ALELPNEEAT TPLDLALHGG HSMLVEDISN FQGRRSPGFS RLRLNEDATL 
       250        260        270        280        290        300 
QFDRSSETLT LTVNHTAEHL LEADIKLFRK YFWDRAFLVK ALDQEAKTER ATMPSGAAET 
       310        320        330        340        350        360 
EEEVRNLESG RSPSEEEEDG QLVKSQADGP SEQEDQDRLV LDHSFDGLKK SKHAPASLAA 
       370        380        390        400        410        420 
GQLSDVPNGG DEVYANCMVI DQVGDLDINY INIEGLSTHT SPESMRSTLG PQACKHILPP 
       430        440        450        460        470        480 
DTSPCGHLLC EDSDRTLDAA ASQSCMSPPS SHTSNLNLSF GLHGFVKEQS HLKKRSSSLD 
       490        500        510        520        530        540 
ALVADSEEEG RSEPPICYAV GSQSSPRTGL PGGDELDSFD ANTEPDCNIS RTESLSLSST 
       550        560        570        580        590        600 
LHSKESLLSG IRSRSYSCSS PKISSGKSRL VRDFTVCSSS EEQRSYSFQE PPGEKRIQEE 
       610        620        630        640        650        660 
EWDDYIIPAK AESEKHKVSR TFSFLMNRMT SPRNKSKMKN KDTKDKEKLN RHQFVPGTFS 
       670        680        690        700        710        720 
GVLQCSGCDK TLLGKESLQC ANCKANTHKG CKDTVPPCTK KFQDKYNKNK PQTILGSSSV 
       730        740        750        760        770        780 
RDVPPPGLSL HPSPSMPIGL PAGRKETAGQ AHPLSRSVPG TTLESFRRAV TSLESEGDSN 
       790        800        810        820        830        840 
SWRSRSHSDE LFQSMGSSPS TESFMMEDVV DSSLWSELSS DAQEFEAESW SLVVDPSFCS 
       850        860        870        880        890        900 
RQEKDVIKRQ DVIFELMQTE VHHIQTLLIM SEVFRKGMKE ELQLDHSTVD RIFPCLDELL 
       910        920        930        940        950        960 
ETHKHFFFSM KERRQESCTG NDRNFVINQI GDILVQQFSE ENASKMKRIY GDFCSHHKEA 
       970        980        990       1000       1010       1020 
MSLFKELQQN KKFQNFIKIR NSNLLARRRG IPECILLVTQ RITKYPVLVE RILQYTKERT 
      1030       1040       1050       1060       1070       1080 
EEHRDLCRAL GLIKDMIAAV DLKVSEYEKN QKWLEILNKI ENKTYTKLKN GHVFRKQALM 
      1090       1100       1110       1120       1130       1140 
SQERALLHDG LVYWKTATGR FKDILALLLT DVLLFLQEKD QKYIFAAVDQ KPSVISLQKL 
      1150       1160       1170       1180       1190       1200 
IAREVANEER GMFLISASSA GPEMYEIHTS SKEERNNWMR RIQQAVESCP EEEGGRTSES 
      1210       1220       1230       1240       1250       1260 
DEERRKADAR VAKIQQCQEI LSNQDQQICT YLEEKLHIYA ELGELSGFED VHLEPHLLIK 
      1270       1280       1290       1300       1310       1320 
PDPGEPPQAA SLLAAALREA ESLQVAVKAS KLADVSQPSE EGPGGAVLAD TLSAQDAPAS 
      1330       1340       1350       1360       1370       1380 
PTAFTEGTEG RGCWDVDPRL QGVVTDLAVS DAGEKVEYRS FSGSSQSEII QAIQNLTRLL 
      1390       1400       1410       1420       1430       1440 
YSLQAALTIQ DSHIEIHKLV LQQQESLAPS HSFRGGPLQD QEKSRYLEKH REELANIHKL 
      1450       1460       1470       1480       1490       1500 
QYQFQQEQRR WHRTCDQQQR EQEAQESWLQ ARERECQSQE ELLLRHRSEL DHQLQEYQQN 
      1510       1520       1530       1540       1550       1560 
LERLREGQRM VERERQRMRD QQGLLGHCKH SRQRSLPAVF SPGSKEVTEL NRAESLCHEK 
      1570       1580       1590       1600       1610       1620 
SFFLNDAFTH MSLNTSNKPN PSGAPWDAHP PGGSHLDLAR TSDSQIEVKM DVSQPSDVNS 
      1630       1640       1650       1660       1670       1680 
ELWTTGLGPQ RPARQESIKD SCKNVADLNS FQTESPDPQD SNQRGPQPQT LITEAKLTPP 
      1690       1700    
MAAGHGGDAG DGAEENIVYL 

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P0C6P5-1-unknown MELSCS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...NIVYL 1700 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)