TopFIND 4.0

P10253: Lysosomal alpha-glucosidase

General Information

Protein names
- Lysosomal alpha-glucosidase
- 3.2.1.20 {ECO:0000269|PubMed:18429042, ECO:0000269|PubMed:1856189, ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:7717400}
- Acid maltase
- Aglucosidase alfa
- 76 kDa lysosomal alpha-glucosidase
- 70 kDa lysosomal alpha-glucosidase
Gene names GAA
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P10253

4

N-termini

3

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGVRHPPCSH RLLAVCALVS LATAALLGHI LLHDFLLVPR ELSGSSPVLE ETHPAHQQGA 
        70         80         90        100        110        120 
SRPGPRDAQA HPGRPRAVPT QCDVPPNSRF DCAPDKAITQ EQCEARGCCY IPAKQGLQGA 
       130        140        150        160        170        180 
QMGQPWCFFP PSYPSYKLEN LSSSEMGYTA TLTRTTPTFF PKDILTLRLD VMMETENRLH 
       190        200        210        220        230        240 
FTIKDPANRR YEVPLETPHV HSRAPSPLYS VEFSEEPFGV IVRRQLDGRV LLNTTVAPLF 
       250        260        270        280        290        300 
FADQFLQLST SLPSQYITGL AEHLSPLMLS TSWTRITLWN RDLAPTPGAN LYGSHPFYLA 
       310        320        330        340        350        360 
LEDGGSAHGV FLLNSNAMDV VLQPSPALSW RSTGGILDVY IFLGPEPKSV VQQYLDVVGY 
       370        380        390        400        410        420 
PFMPPYWGLG FHLCRWGYSS TAITRQVVEN MTRAHFPLDV QWNDLDYMDS RRDFTFNKDG 
       430        440        450        460        470        480 
FRDFPAMVQE LHQGGRRYMM IVDPAISSSG PAGSYRPYDE GLRRGVFITN ETGQPLIGKV 
       490        500        510        520        530        540 
WPGSTAFPDF TNPTALAWWE DMVAEFHDQV PFDGMWIDMN EPSNFIRGSE DGCPNNELEN 
       550        560        570        580        590        600 
PPYVPGVVGG TLQAATICAS SHQFLSTHYN LHNLYGLTEA IASHRALVKA RGTRPFVISR 
       610        620        630        640        650        660 
STFAGHGRYA GHWTGDVWSS WEQLASSVPE ILQFNLLGVP LVGADVCGFL GNTSEELCVR 
       670        680        690        700        710        720 
WTQLGAFYPF MRNHNSLLSL PQEPYSFSEP AQQAMRKALT LRYALLPHLY TLFHQAHVAG 
       730        740        750        760        770        780 
ETVARPLFLE FPKDSSTWTV DHQLLWGEAL LITPVLQAGK AEVTGYFPLG TWYDLQTVPV 
       790        800        810        820        830        840 
EALGSLPPPP AAPREPAIHS EGQWVTLPAP LDTINVHLRA GYIIPLQGPG LTTTESRQQP 
       850        860        870        880        890        900 
MALAVALTKG GEARGELFWD DGESLEVLER GAYTQVIFLA RNNTIVNELV RVTSEGAGLQ 
       910        920        930        940        950    
LQKVTVLGVA TAPQQVLSNG VPVSNFTYSP DTKVLDICVS LLMGEQFLVS WC

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P10253-28-unknown GHILLH... 28 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P10253-70-unknown AHPGRP... 70 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P10253-123-unknown GQPWCF... 123 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P10253-204-unknown APSPLY... 204 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)