TopFIND 4.0

P10632: Cytochrome P450 2C8 {ECO:0000303|PubMed:26427316}

General Information

Protein names
- Cytochrome P450 2C8 {ECO:0000303|PubMed:26427316}
- 1.14.14.- {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:7574697}
- CYPIIC8
- Cytochrome P450 IIC2
- Cytochrome P450 MP-12
- Cytochrome P450 MP-20
- Cytochrome P450 form 1
- S-mephenytoin 4-hydroxylase
Gene names CYP2C8
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P10632

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV 
        70         80         90        100        110        120 
YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW 
       130        140        150        160        170        180 
KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS 
       190        200        210        220        230        240 
VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT 
       250        260        270        280        290        300 
RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE 
       310        320        330        340        350        360 
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD 
       370        380        390        400        410        420 
LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK 
       430        440        450        460        470        480 
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP 
       490    
PSYQICFIPV 

Isoforms

- Isoform 2 of Cytochrome P450 2C8

Sequence View

        10         20         30         40         50         60 
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV 
        70         80         90        100        110        120 
YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW 
       130        140        150        160        170        180 
KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS 
       190        200        210        220        230        240 
VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT 
       250        260        270        280        290        300 
RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE 
       310        320        330        340        350        360 
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD 
       370        380        390        400        410        420 
LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK 
       430        440        450        460        470        480 
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP 
       490    
PSYQICFIPV 



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P10632-1-unknown MEPFVV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...CFIPV 490 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...CFIPV 490 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt67134

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)