TopFIND 4.0

P10635: Cytochrome P450 2D6 {ECO:0000303|PubMed:18698000}

General Information

Protein names
- Cytochrome P450 2D6 {ECO:0000303|PubMed:18698000}
- 1.14.14.- {ECO:0000269|PubMed:18698000, ECO:0000269|PubMed:21289075}
- CYPIID6
- Cholesterol 25-hydroxylase {ECO:0000305|PubMed:21576599}
- Cytochrome P450-DB1
- Debrisoquine 4-hydroxylase
Gene names CYP2D6
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P10635

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ 
        70         80         90        100        110        120 
LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD RPPVPITQIL GFGPRSQGVF 
       130        140        150        160        170        180 
LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK 
       190        200        210        220        230        240 
AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV 
       250        260        270        280        290        300 
LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA 
       310        320        330        340        350        360 
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ AHMPYTTAVI 
       370        380        390        400        410        420 
HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS SVLKDEAVWE KPFRFHPEHF 
       430        440        450        460        470        480 
LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV 
       490    
FAFLVSPSPY ELCAVPR

Isoforms

- Isoform 2 of Cytochrome P450 2D6

Sequence View

        10         20         30         40         50         60 
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ 
        70         80         90        100        110        120 
LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD RPPVPITQIL GFGPRSQGVF 
       130        140        150        160        170        180 
LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK 
       190        200        210        220        230        240 
AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV 
       250        260        270        280        290        300 
LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA 
       310        320        330        340        350        360 
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ AHMPYTTAVI 
       370        380        390        400        410        420 
HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS SVLKDEAVWE KPFRFHPEHF 
       430        440        450        460        470        480 
LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV 
       490    
FAFLVSPSPY ELCAVPR



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P10635-1-unknown MGLEAL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P10635-1-unknown MGLEAL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt71518

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...CAVPR 497 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...CAVPR 497 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt67136

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)