P11802: Cyclin-dependent kinase 4

General Information

Protein names	- Cyclin-dependent kinase 4 - 2.7.11.22 - Cell division protein kinase 4 - PSK-J3
Gene names	CDK4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P11802

6 N-termini

7 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP ISTVREVALL
        70         80         90        100        110        120
RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL
       130        140        150        160        170        180
MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY
       190        200        210        220        230        240
RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR
       250        260        270        280        290        300
DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG

NPE

Isoforms

- Isoform 2 of Cyclin-dependent kinase 4

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 7 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P11802-2-unknown	MATSRY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11802-2-Acetylation	ATSRYE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11802-36-	SVRVPN...	36			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P11802-75-unknown	MDVCAT...	75		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447779
P11802-75-unknown	MDVCAT...	75		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447274
P11802-75-unknown	MDVCAT...	75		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449391
P11802-121-unknown	MRQFLR...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439076
P11802-264-unknown	MEESGA...	264		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447005

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GLPAET	115	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446763
...SYQMAL	170	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448963
...SVGCIF	203	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449179
...CIFAEM	206	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449391
...PVQSVV	260	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447274
...FNPHKR	282	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447779
...EGNPE	303	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)