P11831: Serum response factor

General Information

Protein names	- Serum response factor - SRF
Gene names	SRF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P11831

4 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLPTQAGAAA ALGRGSALGG SLNRTPTGRP GGGGGTRGAN GGRVPGNGAG LGPGRLEREA
        70         80         90        100        110        120
AAAAATTPAP TAGALYSGSE GDSESGEEEE LGAERRGLKR SLSEMEIGMV VGGPEASAAA
       130        140        150        160        170        180
TGGYGPVSGA VSGAKPGKKT RGRVKIKMEF IDNKLRRYTT FSKRKTGIMK KAYELSTLTG
       190        200        210        220        230        240
TQVLLLVASE TGHVYTFATR KLQPMITSET GKALIQTCLN SPDSPPRSDP TTDQRMSATG
       250        260        270        280        290        300
FEETDLTYQV SESDSSGETK DTLKPAFTVT NLPGTTSTIQ TAPSTSTTMQ VSSGPSFPIT
       310        320        330        340        350        360
NYLAPVSASV SPSAVSSANG TVLKSTGSGP VSSGGLMQLP TSFTLMPGGA VAQQVPVQAI
       370        380        390        400        410        420
QVHQAPQQAS PSRDSSTDLT QTSSSGTVTL PATIMTSSVP TTVGGHMMYP SPHAVMYAPT
       430        440        450        460        470        480
SGLGDGSLTV LNAFSQAPST MQVSHSQVQE PGGVPQVFLT ASSGTVQIPV SAVQLHQMAV
       490        500
IGQQAGSSSN LTELQVVNLD TAHSTKSE

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P11831-1-unknown	MLPTQA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P11831-205-unknown	MITSET...	205	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401320
P11831-246-unknown	LTYQVS...	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1650
P11831-246-unknown	LTYQVS...	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2812
P11831-255-unknown	SSGETK...	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1651

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FEETDL	245	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1650
...FEETDL	245	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2812
...VSESDS	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1651
...STKSE	508	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	245	ETDL.\|.LTYQ	inferred from experiment	unknown	MEROPS	Schwartz RJ	Chang J et al.:Inhibitory cardiac transcriptio... (C14.003)	12874181,
CASP7_HUMAN	245	ETDL.\|.LTYQ	inferred from experiment	unknown	MEROPS	Shaw PE	Drewett V et al.:Serum response factor cleavage ... (C14.003)	11387340,
CASP3_HUMAN	254	ESDS.\|.SSGE	inferred from experiment	unknown	MEROPS	Shaw PE	Drewett V et al.:Serum response factor cleavage ... (C14.003)	11387340,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)