TopFIND 4.0

P12694: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

General Information

Protein names
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- 1.2.4.4
- Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain
- BCKDE1A
- BCKDH E1-alpha
Gene names BCKDHA
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P12694

1

N-termini

3

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAVAIAAARV WRLNRGLSQA ALLLLRQPGA RGLARSHPPR QQQQFSSLDD KPQFPGASAE 
        70         80         90        100        110        120 
FIDKLEFIQP NVISGIPIYR VMDRQGQIIN PSEDPHLPKE KVLKLYKSMT LLNTMDRILY 
       130        140        150        160        170        180 
ESQRQGRISF YMTNYGEEGT HVGSAAALDN TDLVFGQYRE AGVLMYRDYP LELFMAQCYG 
       190        200        210        220        230        240 
NISDLGKGRQ MPVHYGCKER HFVTISSPLA TQIPQAVGAA YAAKRANANR VVICYFGEGA 
       250        260        270        280        290        300 
ASEGDAHAGF NFAATLECPI IFFCRNNGYA ISTPTSEQYR GDGIAARGPG YGIMSIRVDG 
       310        320        330        340        350        360 
NDVFAVYNAT KEARRRAVAE NQPFLIEAMT YRIGHHSTSD DSSAYRSVDE VNYWDKQDHP 
       370        380        390        400        410        420 
ISRLRHYLLS QGWWDEEQEK AWRKQSRRKV MEAFEQAERK PKPNPNLLFS DVYQEMPAQL 
       430        440    
RKQQESLARH LQTYGEHYPL DHFDK

Isoforms

- Isoform 2 of 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Sequence View

        10         20         30         40         50         60 
MAVAIAAARV WRLNRGLSQA ALLLLRQPGA RGLARSHPPR QQQQFSSLDD KPQFPGASAE 
        70         80         90        100        110        120 
FIDKLEFIQP NVISGIPIYR VMDRQGQIIN PSEDPHLPKE KVLKLYKSMT LLNTMDRILY 
       130        140        150        160        170        180 
ESQRQGRISF YMTNYGEEGT HVGSAAALDN TDLVFGQYRE AGVLMYRDYP LELFMAQCYG 
       190        200        210        220        230        240 
NISDLGKGRQ MPVHYGCKER HFVTISSPLA TQIPQAVGAA YAAKRANANR VVICYFGEGA 
       250        260        270        280        290        300 
ASEGDAHAGF NFAATLECPI IFFCRNNGYA ISTPTSEQYR GDGIAARGPG YGIMSIRVDG 
       310        320        330        340        350        360 
NDVFAVYNAT KEARRRAVAE NQPFLIEAMT YRIGHHSTSD DSSAYRSVDE VNYWDKQDHP 
       370        380        390        400        410        420 
ISRLRHYLLS QGWWDEEQEK AWRKQSRRKV MEAFEQAERK PKPNPNLLFS DVYQEMPAQL 
       430        440    
RKQQESLARH LQTYGEHYPL DHFDK



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Protein Neighborhood

Domains & Features

1 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P12694-46-unknown SSLDDK... 46 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)