TopFIND 4.0

P13009: Methionine synthase

General Information

Protein names
- Methionine synthase
- 2.1.1.13
- 5-methyltetrahydrofolate--homocysteine methyltransferase
- Methionine synthase, vitamin-B12-dependent
- MS
Gene names metH
Organism Escherichia coli
Protease Family
Protease ID
Chromosome location
UniProt ID P13009

1

N-termini

1

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSSKVEQLRA QLNERILVLD GGMGTMIQSY RLNEADFRGE RFADWPCDLK GNNDLLVLSK 
        70         80         90        100        110        120 
PEVIAAIHNA YFEAGADIIE TNTFNSTTIA MADYQMESLS AEINFAAAKL ARACADEWTA 
       130        140        150        160        170        180 
RTPEKPRYVA GVLGPTNRTA SISPDVNDPA FRNITFDGLV AAYRESTKAL VEGGADLILI 
       190        200        210        220        230        240 
ETVFDTLNAK AAVFAVKTEF EALGVELPIM ISGTITDASG RTLSGQTTEA FYNSLRHAEA 
       250        260        270        280        290        300 
LTFGLNCALG PDELRQYVQE LSRIAECYVT AHPNAGLPNA FGEYDLDADT MAKQIREWAQ 
       310        320        330        340        350        360 
AGFLNIVGGC CGTTPQHIAA MSRAVEGLAP RKLPEIPVAC RLSGLEPLNI GEDSLFVNVG 
       370        380        390        400        410        420 
ERTNVTGSAK FKRLIKEEKY SEALDVARQQ VENGAQIIDI NMDEGMLDAE AAMVRFLNLI 
       430        440        450        460        470        480 
AGEPDIARVP IMIDSSKWDV IEKGLKCIQG KGIVNSISMK EGVDAFIHHA KLLRRYGAAV 
       490        500        510        520        530        540 
VVMAFDEQGQ ADTRARKIEI CRRAYKILTE EVGFPPEDII FDPNIFAVAT GIEEHNNYAQ 
       550        560        570        580        590        600 
DFIGACEDIK RELPHALISG GVSNVSFSFR GNDPVREAIH AVFLYYAIRN GMDMGIVNAG 
       610        620        630        640        650        660 
QLAIYDDLPA ELRDAVEDVI LNRRDDGTER LLELAEKYRG SKTDDTANAQ QAEWRSWEVN 
       670        680        690        700        710        720 
KRLEYSLVKG ITEFIEQDTE EARQQATRPI EVIEGPLMDG MNVVGDLFGE GKMFLPQVVK 
       730        740        750        760        770        780 
SARVMKQAVA YLEPFIEASK EQGKTNGKMV IATVKGDVHD IGKNIVGVVL QCNNYEIVDL 
       790        800        810        820        830        840 
GVMVPAEKIL RTAKEVNADL IGLSGLITPS LDEMVNVAKE MERQGFTIPL LIGGATTSKA 
       850        860        870        880        890        900 
HTAVKIEQNY SGPTVYVQNA SRTVGVVAAL LSDTQRDDFV ARTRKEYETV RIQHGRKKPR 
       910        920        930        940        950        960 
TPPVTLEAAR DNDFAFDWQA YTPPVAHRLG VQEVEASIET LRNYIDWTPF FMTWSLAGKY 
       970        980        990       1000       1010       1020 
PRILEDEVVG VEAQRLFKDA NDMLDKLSAE KTLNPRGVVG LFPANRVGDD IEIYRDETRT 
      1030       1040       1050       1060       1070       1080 
HVINVSHHLR QQTEKTGFAN YCLADFVAPK LSGKADYIGA FAVTGGLEED ALADAFEAQH 
      1090       1100       1110       1120       1130       1140 
DDYNKIMVKA LADRLAEAFA EYLHERVRKV YWGYAPNENL SNEELIRENY QGIRPAPGYP 
      1150       1160       1170       1180       1190       1200 
ACPEHTEKAT IWELLEVEKH TGMKLTESFA MWPGASVSGW YFSHPDSKYY AVAQIQRDQV 
      1210       1220    
EDYARRKGMS VTEVERWLAP NLGYDAD

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 1 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P13009-2-unknown SSKVEQ... 2 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P13009-2-unknown SSKVEQ... 2 inferred from cleavage unknown TopFIND Inferred from cleavage TC28216

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...GYDAD 1227 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)