TopFIND 4.0

P13196: 5-aminolevulinate synthase, nonspecific, mitochondrial

General Information

Protein names
- 5-aminolevulinate synthase, nonspecific, mitochondrial
- ALAS-H
- 2.3.1.37
- 5-aminolevulinic acid synthase 1
- Delta-ALA synthase 1
- Delta-aminolevulinate synthase 1
Gene names ALAS1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P13196

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MESVVRRCPF LSRVPQAFLQ KAGKSLLFYA QNCPKMMEVG AKPAPRALST AAVHYQQIKE 
        70         80         90        100        110        120 
TPPASEKDKT AKAKVQQTPD GSQQSPDGTQ LPSGHPLPAT SQGTASKCPF LAAQMNQRGS 
       130        140        150        160        170        180 
SVFCKASLEL QEDVQEMNAV RKEVAETSAG PSVVSVKTDG GDPSGLLKNF QDIMQKQRPE 
       190        200        210        220        230        240 
RVSHLLQDNL PKSVSTFQYD RFFEKKIDEK KNDHTYRVFK TVNRRAHIFP MADDYSDSLI 
       250        260        270        280        290        300 
TKKQVSVWCS NDYLGMSRHP RVCGAVMDTL KQHGAGAGGT RNISGTSKFH VDLERELADL 
       310        320        330        340        350        360 
HGKDAALLFS SCFVANDSTL FTLAKMMPGC EIYSDSGNHA SMIQGIRNSR VPKYIFRHND 
       370        380        390        400        410        420 
VSHLRELLQR SDPSVPKIVA FETVHSMDGA VCPLEELCDV AHEFGAITFV DEVHAVGLYG 
       430        440        450        460        470        480 
ARGGGIGDRD GVMPKMDIIS GTLGKAFGCV GGYIASTSSL IDTVRSYAAG FIFTTSLPPM 
       490        500        510        520        530        540 
LLAGALESVR ILKSAEGRVL RRQHQRNVKL MRQMLMDAGL PVVHCPSHII PVRVADAAKN 
       550        560        570        580        590        600 
TEVCDELMSR HNIYVQAINY PTVPRGEELL RIAPTPHHTP QMMNYFLENL LVTWKQVGLE 
       610        620        630        640    
LKPHSSAECN FCRRPLHFEV MSEREKSYFS GLSKLVSAQA 

Isoforms

- Isoform 2 of 5-aminolevulinate synthase, nonspecific, mitochondrial

Sequence View

        10         20         30         40         50         60 
MESVVRRCPF LSRVPQAFLQ KAGKSLLFYA QNCPKMMEVG AKPAPRALST AAVHYQQIKE 
        70         80         90        100        110        120 
TPPASEKDKT AKAKVQQTPD GSQQSPDGTQ LPSGHPLPAT SQGTASKCPF LAAQMNQRGS 
       130        140        150        160        170        180 
SVFCKASLEL QEDVQEMNAV RKEVAETSAG PSVVSVKTDG GDPSGLLKNF QDIMQKQRPE 
       190        200        210        220        230        240 
RVSHLLQDNL PKSVSTFQYD RFFEKKIDEK KNDHTYRVFK TVNRRAHIFP MADDYSDSLI 
       250        260        270        280        290        300 
TKKQVSVWCS NDYLGMSRHP RVCGAVMDTL KQHGAGAGGT RNISGTSKFH VDLERELADL 
       310        320        330        340        350        360 
HGKDAALLFS SCFVANDSTL FTLAKMMPGC EIYSDSGNHA SMIQGIRNSR VPKYIFRHND 
       370        380        390        400        410        420 
VSHLRELLQR SDPSVPKIVA FETVHSMDGA VCPLEELCDV AHEFGAITFV DEVHAVGLYG 
       430        440        450        460        470        480 
ARGGGIGDRD GVMPKMDIIS GTLGKAFGCV GGYIASTSSL IDTVRSYAAG FIFTTSLPPM 
       490        500        510        520        530        540 
LLAGALESVR ILKSAEGRVL RRQHQRNVKL MRQMLMDAGL PVVHCPSHII PVRVADAAKN 
       550        560        570        580        590        600 
TEVCDELMSR HNIYVQAINY PTVPRGEELL RIAPTPHHTP QMMNYFLENL LVTWKQVGLE 
       610        620        630        640    
LKPHSSAECN FCRRPLHFEV MSEREKSYFS GLSKLVSAQA 



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P13196-1-unknown MESVVR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt76906
    P13196-57-unknown QIKETP... 57 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P13196-57-unknown QIKETP... 57 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt115707

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VSAQA 640 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)