TopFIND 4.0

P14408: Fumarate hydratase, mitochondrial {ECO:0000250|UniProtKB:P07954}

General Information

Protein names
- Fumarate hydratase, mitochondrial {ECO:0000250|UniProtKB:P07954}
- Fumarase {ECO:0000303|PubMed:2914923}
- 4.2.1.2 {ECO:0000250|UniProtKB:P07954}
Gene names Fh
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P14408

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MNRAFCLLAR SRRFPRVPSA GAVLSGEAAT LPRCAPNVVR MASQNSFRIE YDTFGELKVP 
        70         80         90        100        110        120 
TDKYYGAQTV RSTMNFKIGG ATERMPIPVI KAFGILKRAA AEVNQEYGLD PKIASAIMKA 
       130        140        150        160        170        180 
ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKK PVHPNDHVNK 
       190        200        210        220        230        240 
SQSSNDTFPT AMHIAAALEV HQVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT 
       250        260        270        280        290        300 
LGQEFSGYVQ QVQYAMERIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL 
       310        320        330        340        350        360 
PFVTAPNKFE ALAAHDALVE LSGAMNTTAC SLMKIANDIR FLGSGPRSGL GELILPENEP 
       370        380        390        400        410        420 
GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL 
       430        440        450        460        470        480 
GDASVSFTEN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK 
       490        500    
ETAIELGYLT AEQFDEWVKP KDMLGPK

Isoforms

- Isoform Cytoplasmic of Fumarate hydratase, mitochondrial - Isoform Cytoplasmic of Fumarate hydratase, mitochondrial

Sequence View

        10         20         30         40         50         60 
MNRAFCLLAR SRRFPRVPSA GAVLSGEAAT LPRCAPNVVR MASQNSFRIE YDTFGELKVP 
        70         80         90        100        110        120 
TDKYYGAQTV RSTMNFKIGG ATERMPIPVI KAFGILKRAA AEVNQEYGLD PKIASAIMKA 
       130        140        150        160        170        180 
ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKK PVHPNDHVNK 
       190        200        210        220        230        240 
SQSSNDTFPT AMHIAAALEV HQVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT 
       250        260        270        280        290        300 
LGQEFSGYVQ QVQYAMERIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL 
       310        320        330        340        350        360 
PFVTAPNKFE ALAAHDALVE LSGAMNTTAC SLMKIANDIR FLGSGPRSGL GELILPENEP 
       370        380        390        400        410        420 
GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL 
       430        440        450        460        470        480 
GDASVSFTEN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK 
       490        500    
ETAIELGYLT AEQFDEWVKP KDMLGPK         10         20         30         40         50         60 
MNRAFCLLAR SRRFPRVPSA GAVLSGEAAT LPRCAPNVVR MASQNSFRIE YDTFGELKVP 
        70         80         90        100        110        120 
TDKYYGAQTV RSTMNFKIGG ATERMPIPVI KAFGILKRAA AEVNQEYGLD PKIASAIMKA 
       130        140        150        160        170        180 
ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKK PVHPNDHVNK 
       190        200        210        220        230        240 
SQSSNDTFPT AMHIAAALEV HQVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT 
       250        260        270        280        290        300 
LGQEFSGYVQ QVQYAMERIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL 
       310        320        330        340        350        360 
PFVTAPNKFE ALAAHDALVE LSGAMNTTAC SLMKIANDIR FLGSGPRSGL GELILPENEP 
       370        380        390        400        410        420 
GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL 
       430        440        450        460        470        480 
GDASVSFTEN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK 
       490        500    
ETAIELGYLT AEQFDEWVKP KDMLGPK



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P14408-41-unknown MASQNS... 41 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt192661
    P14408-42-unknown ASQNSF... 42 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P14408-42-unknown ASQNSF... 42 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt195926

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...MLGPK 507 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...MLGPK 507 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt152607

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)