TopFIND 4.0

P15442: eIF-2-alpha kinase GCN2 {ECO:0000250|UniProtKB:Q9HGN1}

General Information

Protein names
- eIF-2-alpha kinase GCN2 {ECO:0000250|UniProtKB:Q9HGN1}
- 2.7.11.1 {ECO:0000269|PubMed:10983975, ECO:0000269|PubMed:17202131, ECO:0000269|PubMed:2188100, ECO:0000269|PubMed:7623840, ECO:0000269|PubMed:8798780}
- General control non-derepressible protein 2 {ECO:0000312|SGD:S000002691}
- Serine/threonine-protein kinase GCN2 {ECO:0000305}
Gene names GCN2
Organism Saccharomyces cerevisiae
Protease Family
Protease ID
Chromosome location
UniProt ID P15442

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSLSHLTLDQ YYEIQCNELE AIRSIYMDDF TDLTKRKSSW DKQPQIIFEI TLRSVDKEPV 
        70         80         90        100        110        120 
ESSITLHFAM TPMYPYTAPE IEFKNVQNVM DSQLQMLKSE FKKIHNTSRG QEIIFEITSF 
       130        140        150        160        170        180 
TQEKLDEFQN VVNTQSLEDD RLQRIKETKE QLEKEEREKQ QETIKKRSDE QRRIDEIVQR 
       190        200        210        220        230        240 
ELEKRQDDDD DLLFNRTTQL DLQPPSEWVA SGEAIVFSKT IKAKLPNNSM FKFKAVVNPK 
       250        260        270        280        290        300 
PIKLTSDIFS FSKQFLVKPY IPPESPLADF LMSSEMMENF YYLLSEIELD NSYFNTSNGK 
       310        320        330        340        350        360 
KEIANLEKEL ETVLKAKHDN VNRLFGYTVE RMGRNNATFV WKIRLLTEYC NYYPLGDLIQ 
       370        380        390        400        410        420 
SVGFVNLATA RIWMIRLLEG LEAIHKLGIV HKCINLETVI LVKDADFGST IPKLVHSTYG 
       430        440        450        460        470        480 
YTVLNMLSRY PNKNGSSVEL SPSTWIAPEL LKFNNAKPQR LTDIWQLGVL FIQIISGSDI 
       490        500        510        520        530        540 
VMNFETPQEF LDSTSMDETL YDLLSKMLNN DPKKRLGTLE LLPMKFLRTN IDSTINRFNL 
       550        560        570        580        590        600 
VSESVNSNSL ELTPGDTITV RGNGGRTLSQ SSIRRRSFNV GSRFSSINPA TRSRYASDFE 
       610        620        630        640        650        660 
EIAVLGQGAF GQVVKARNAL DSRYYAIKKI RHTEEKLSTI LSEVMLLASL NHQYVVRYYA 
       670        680        690        700        710        720 
AWLEEDSMDE NVFESTDEES DLSESSSDFE ENDLLDQSSI FKNRTNHDLD NSNWDFISGS 
       730        740        750        760        770        780 
GYPDIVFENS SRDDENEDLD HDTSSTSSSE SQDDTDKESK SIQNVPRRRN FVKPMTAVKK 
       790        800        810        820        830        840 
KSTLFIQMEY CENRTLYDLI HSENLNQQRD EYWRLFRQIL EALSYIHSQG IIHRDLKPMN 
       850        860        870        880        890        900 
IFIDESRNVK IGDFGLAKNV HRSLDILKLD SQNLPGSSDN LTSAIGTAMY VATEVLDGTG 
       910        920        930        940        950        960 
HYNEKIDMYS LGIIFFEMIY PFSTGMERVN ILKKLRSVSI EFPPDFDDNK MKVEKKIIRL 
       970        980        990       1000       1010       1020 
LIDHDPNKRP GARTLLNSGW LPVKHQDEVI KEALKSLSNP SSPWQQQVRE SLFNQSYSLT 
      1030       1040       1050       1060       1070       1080 
NDILFDNSVP TSTPFANILR SQMTEEVVKI FRKHGGIENN APPRIFPKAP IYGTQNVYEV 
      1090       1100       1110       1120       1130       1140 
LDKGGTVLQL QYDLTYPMAR YLSKNPSLIS KQYRMQHVYR PPDHSRSSLE PRKFGEIDFD 
      1150       1160       1170       1180       1190       1200 
IISKSSSESG FYDAESLKII DEILTVFPVF EKTNTFFILN HADILESVFN FTNIDKAQRP 
      1210       1220       1230       1240       1250       1260 
LVSRMLSQVG FARSFKEVKN ELKAQLNISS TALNDLELFD FRLDFEAAKK RLYKLMIDSP 
      1270       1280       1290       1300       1310       1320 
HLKKIEDSLS HISKVLSYLK PLEVARNVVI SPLSNYNSAF YKGGIMFHAV YDDGSSRNMI 
      1330       1340       1350       1360       1370       1380 
AAGGRYDTLI SFFARPSGKK SSNTRKAVGF NLAWETIFGI AQNYFKLASG NRIKKRNRFL 
      1390       1400       1410       1420       1430       1440 
KDTAVDWKPS RCDVLISSFS NSLLDTIGVT ILNTLWKQNI KADMLRDCSS VDDVVTGAQQ 
      1450       1460       1470       1480       1490       1500 
DGIDWILLIK QQAYPLTNHK RKYKPLKIKK LSTNVDIDLD LDEFLTLYQQ ETGNKSLIND 
      1510       1520       1530       1540       1550       1560 
SLTLGDKADE FKRWDENSSA GSSQEGDIDD VVAGSTNNQK VIYVPNMATR SKKANKREKW 
      1570       1580       1590       1600       1610       1620 
VYEDAARNSS NMILHNLSNA PIITVDALRD ETLEIISITS LAQKEEWLRK VFGSGNNSTP 
      1630       1640       1650    
RSFATSIYNN LSKEAHKGNR WAILYCHKTG KSSVIDLQR

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P15442-1-unknown MSLSHL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...IDLQR 1659 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)