P16435: NADPH--cytochrome P450 reductase {ECO:0000255|HAMAP-Rule:MF_03212}

General Information

Protein names	- NADPH--cytochrome P450 reductase {ECO:0000255\|HAMAP-Rule:MF_03212} - CPR {ECO:0000255\|HAMAP-Rule:MF_03212} - P450R {ECO:0000255\|HAMAP-Rule:MF_03212} - 1.6.2.4 {ECO:0000255\|HAMAP-Rule:MF_03212}
Gene names	POR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P16435

4 N-termini

10 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGDSHVDTSS TVSEAVAEEV SLFSMTDMIL FSLIVGLLTY WFLFRKKKEE VPEFTKIQTL
        70         80         90        100        110        120
TSSVRESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK DAHRYGMRGM SADPEEYDLA
       130        140        150        160        170        180
DLSSLPEIDN ALVVFCMATY GEGDPTDNAQ DFYDWLQETD VDLSGVKFAV FGLGNKTYEH
       190        200        210        220        230        240
FNAMGKYVDK RLEQLGAQRI FELGLGDDDG NLEEDFITWR EQFWPAVCEH FGVEATGEES
       250        260        270        280        290        300
SIRQYELVVH TDIDAAKVYM GEMGRLKSYE NQKPPFDAKN PFLAAVTTNR KLNQGTERHL
       310        320        330        340        350        360
MHLELDISDS KIRYESGDHV AVYPANDSAL VNQLGKILGA DLDVVMSLNN LDEESNKKHP
       370        380        390        400        410        420
FPCPTSYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE LLRKMASSSG EGKELYLSWV
       430        440        450        460        470        480
VEARRHILAI LQDCPSLRPP IDHLCELLPR LQARYYSIAS SSKVHPNSVH ICAVVVEYET
       490        500        510        520        530        540
KAGRINKGVA TNWLRAKEPA GENGGRALVP MFVRKSQFRL PFKATTPVIM VGPGTGVAPF
       550        560        570        580        590        600
IGFIQERAWL RQQGKEVGET LLYYGCRRSD EDYLYREELA QFHRDGALTQ LNVAFSREQS
       610        620        630        640        650        660
HKVYVQHLLK QDREHLWKLI EGGAHIYVCG DARNMARDVQ NTFYDIVAEL GAMEHAQAVD
       670
YIKKLMTKGR YSLDVWS

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 10 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P16435-2-unknown	MGDSHV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P16435-2-Acetylation	GDSHVD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P16435-184-unknown	MGKYVD...	184		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414244
P16435-260-unknown	MGEMGR...	260		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412490

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SLIVGL	36	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409881
...TKIQTL	59	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399556
...TKIQTL	59	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389719
...VVFCMA	137	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395813
...TYGEGD	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409238
...NAQDFY	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400964
...TDVDLS	163	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389409
...GVKFAV	169	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399327
...FNAMGK	185	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390540
...IYVCGD	630	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000378355
...LDVWS	677	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)