P17342: Atrial natriuretic peptide receptor 3

General Information

Protein names	- Atrial natriuretic peptide receptor 3 - Atrial natriuretic peptide clearance receptor - Atrial natriuretic peptide receptor type C - ANP-C - ANPR-C - NPR-C
Gene names	NPR3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17342

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Atrial natriuretic peptide receptor 3 - Isoform 3 of Atrial natriuretic peptide receptor 3

Sequence View

        10         20         30         40         50         60
MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP QKIEVLVLLP
        70         80         90        100        110        120
QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ VAYEDSDCGN RALFSLVDRV
       130        140        150        160        170        180
AAARGAKPDL ILGPVCEYAA APVARLASHW DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA
       190        200        210        220        230        240
YAKMGEMMLA LFRHHHWSRA ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK
       250        260        270        280        290        300
DLDLEDIVRN IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG
       310        320        330        340        350        360
SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM EDYVNMFVEG
       370        380        390        400        410        420
FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI AGQVSIDANG DRYGDFSVIA
       430        440        450        460        470        480
MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY PWGPLKLRID ENRIVEHTNS SPCKSSGGLE
       490        500        510        520        530        540
ESAVTGIVVG ALLGAGLLMA FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV

A         10         20         30         40         50         60
MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP QKIEVLVLLP
        70         80         90        100        110        120
QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ VAYEDSDCGN RALFSLVDRV
       130        140        150        160        170        180
AAARGAKPDL ILGPVCEYAA APVARLASHW DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA
       190        200        210        220        230        240
YAKMGEMMLA LFRHHHWSRA ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK
       250        260        270        280        290        300
DLDLEDIVRN IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG
       310        320        330        340        350        360
SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM EDYVNMFVEG
       370        380        390        400        410        420
FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI AGQVSIDANG DRYGDFSVIA
       430        440        450        460        470        480
MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY PWGPLKLRID ENRIVEHTNS SPCKSSGGLE
       490        500        510        520        530        540
ESAVTGIVVG ALLGAGLLMA FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV

A

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P17342-1-unknown	MPSLLV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67031
P17342-27-unknown	GGVGGG...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P17342-27-unknown	GGVGGG...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114242
P17342-46-unknown	EALPPQ...	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16313
P17342-46-unknown	EALPPQ...	46	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138843

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GRQERE	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16313
...GRQERE	45	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121905
...HFSVA	541	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HFSVA	541	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62650
...HFSVA	541	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62649

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	45	QERE.\|.EALP	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)