P17405: Sphingomyelin phosphodiesterase

General Information

Protein names	- Sphingomyelin phosphodiesterase - 3.1.4.12 {ECO:0000269\|PubMed:15877209, ECO:0000269\|PubMed:1718266, ECO:0000269\|PubMed:1840600, ECO:0000269\|PubMed:18815062, ECO:0000269\|PubMed:26084044, ECO:0000269\|PubMed:8702487} - Acid sphingomyelinase {ECO:0000303\|PubMed:27349982} - aSMase
Gene names	SMPD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17405

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Sphingomyelin phosphodiesterase - Isoform 3 of Sphingomyelin phosphodiesterase - Isoform 4 of Sphingomyelin phosphodiesterase - Isoform 2 of Sphingomyelin phosphodiesterase - Isoform 3 of Sphingomyelin phosphodiesterase - Isoform 4 of Sphingomyelin phosphodiesterase

Sequence View

        10         20         30         40         50         60
MPRYGASLRQ SCPRSGREQG QDGTAGAPGL LWMGLVLALA LALALALALS DSRVLWAPAE
        70         80         90        100        110        120
AHPLSPQGHP ARLHRIVPRL RDVFGWGNLT CPICKGLFTA INLGLKKEPN VARVGSVAIK
       130        140        150        160        170        180
LCNLLKIAPP AVCQSIVHLF EDDMVEVWRR SVLSPSEACG LLLGSTCGHW DIFSSWNISL
       190        200        210        220        230        240
PTVPKPPPKP PSPPAPGAPV SRILFLTDLH WDHDYLEGTD PDCADPLCCR RGSGLPPASR
       250        260        270        280        290        300
PGAGYWGEYS KCDLPLRTLE SLLSGLGPAG PFDMVYWTGD IPAHDVWHQT RQDQLRALTT
       310        320        330        340        350        360
VTALVRKFLG PVPVYPAVGN HESTPVNSFP PPFIEGNHSS RWLYEAMAKA WEPWLPAEAL
       370        380        390        400        410        420
RTLRIGGFYA LSPYPGLRLI SLNMNFCSRE NFWLLINSTD PAGQLQWLVG ELQAAEDRGD
       430        440        450        460        470        480
KVHIIGHIPP GHCLKSWSWN YYRIVARYEN TLAAQFFGHT HVDEFEVFYD EETLSRPLAV
       490        500        510        520        530        540
AFLAPSATTY IGLNPGYRVY QIDGNYSGSS HVVLDHETYI LNLTQANIPG AIPHWQLLYR
       550        560        570        580        590        600
ARETYGLPNT LPTAWHNLVY RMRGDMQLFQ TFWFLYHKGH PPSEPCGTPC RLATLCAQLS
       610        620        630
ARADSPALCR HLMPDGSLPE AQSLWPRPLF C         10         20         30         40         50         60
MPRYGASLRQ SCPRSGREQG QDGTAGAPGL LWMGLVLALA LALALALALS DSRVLWAPAE
        70         80         90        100        110        120
AHPLSPQGHP ARLHRIVPRL RDVFGWGNLT CPICKGLFTA INLGLKKEPN VARVGSVAIK
       130        140        150        160        170        180
LCNLLKIAPP AVCQSIVHLF EDDMVEVWRR SVLSPSEACG LLLGSTCGHW DIFSSWNISL
       190        200        210        220        230        240
PTVPKPPPKP PSPPAPGAPV SRILFLTDLH WDHDYLEGTD PDCADPLCCR RGSGLPPASR
       250        260        270        280        290        300
PGAGYWGEYS KCDLPLRTLE SLLSGLGPAG PFDMVYWTGD IPAHDVWHQT RQDQLRALTT
       310        320        330        340        350        360
VTALVRKFLG PVPVYPAVGN HESTPVNSFP PPFIEGNHSS RWLYEAMAKA WEPWLPAEAL
       370        380        390        400        410        420
RTLRIGGFYA LSPYPGLRLI SLNMNFCSRE NFWLLINSTD PAGQLQWLVG ELQAAEDRGD
       430        440        450        460        470        480
KVHIIGHIPP GHCLKSWSWN YYRIVARYEN TLAAQFFGHT HVDEFEVFYD EETLSRPLAV
       490        500        510        520        530        540
AFLAPSATTY IGLNPGYRVY QIDGNYSGSS HVVLDHETYI LNLTQANIPG AIPHWQLLYR
       550        560        570        580        590        600
ARETYGLPNT LPTAWHNLVY RMRGDMQLFQ TFWFLYHKGH PPSEPCGTPC RLATLCAQLS
       610        620        630
ARADSPALCR HLMPDGSLPE AQSLWPRPLF C         10         20         30         40         50         60
MPRYGASLRQ SCPRSGREQG QDGTAGAPGL LWMGLVLALA LALALALALS DSRVLWAPAE
        70         80         90        100        110        120
AHPLSPQGHP ARLHRIVPRL RDVFGWGNLT CPICKGLFTA INLGLKKEPN VARVGSVAIK
       130        140        150        160        170        180
LCNLLKIAPP AVCQSIVHLF EDDMVEVWRR SVLSPSEACG LLLGSTCGHW DIFSSWNISL
       190        200        210        220        230        240
PTVPKPPPKP PSPPAPGAPV SRILFLTDLH WDHDYLEGTD PDCADPLCCR RGSGLPPASR
       250        260        270        280        290        300
PGAGYWGEYS KCDLPLRTLE SLLSGLGPAG PFDMVYWTGD IPAHDVWHQT RQDQLRALTT
       310        320        330        340        350        360
VTALVRKFLG PVPVYPAVGN HESTPVNSFP PPFIEGNHSS RWLYEAMAKA WEPWLPAEAL
       370        380        390        400        410        420
RTLRIGGFYA LSPYPGLRLI SLNMNFCSRE NFWLLINSTD PAGQLQWLVG ELQAAEDRGD
       430        440        450        460        470        480
KVHIIGHIPP GHCLKSWSWN YYRIVARYEN TLAAQFFGHT HVDEFEVFYD EETLSRPLAV
       490        500        510        520        530        540
AFLAPSATTY IGLNPGYRVY QIDGNYSGSS HVVLDHETYI LNLTQANIPG AIPHWQLLYR
       550        560        570        580        590        600
ARETYGLPNT LPTAWHNLVY RMRGDMQLFQ TFWFLYHKGH PPSEPCGTPC RLATLCAQLS
       610        620        630
ARADSPALCR HLMPDGSLPE AQSLWPRPLF C         10         20         30         40         50         60
MPRYGASLRQ SCPRSGREQG QDGTAGAPGL LWMGLVLALA LALALALALS DSRVLWAPAE
        70         80         90        100        110        120
AHPLSPQGHP ARLHRIVPRL RDVFGWGNLT CPICKGLFTA INLGLKKEPN VARVGSVAIK
       130        140        150        160        170        180
LCNLLKIAPP AVCQSIVHLF EDDMVEVWRR SVLSPSEACG LLLGSTCGHW DIFSSWNISL
       190        200        210        220        230        240
PTVPKPPPKP PSPPAPGAPV SRILFLTDLH WDHDYLEGTD PDCADPLCCR RGSGLPPASR
       250        260        270        280        290        300
PGAGYWGEYS KCDLPLRTLE SLLSGLGPAG PFDMVYWTGD IPAHDVWHQT RQDQLRALTT
       310        320        330        340        350        360
VTALVRKFLG PVPVYPAVGN HESTPVNSFP PPFIEGNHSS RWLYEAMAKA WEPWLPAEAL
       370        380        390        400        410        420
RTLRIGGFYA LSPYPGLRLI SLNMNFCSRE NFWLLINSTD PAGQLQWLVG ELQAAEDRGD
       430        440        450        460        470        480
KVHIIGHIPP GHCLKSWSWN YYRIVARYEN TLAAQFFGHT HVDEFEVFYD EETLSRPLAV
       490        500        510        520        530        540
AFLAPSATTY IGLNPGYRVY QIDGNYSGSS HVVLDHETYI LNLTQANIPG AIPHWQLLYR
       550        560        570        580        590        600
ARETYGLPNT LPTAWHNLVY RMRGDMQLFQ TFWFLYHKGH PPSEPCGTPC RLATLCAQLS
       610        620        630
ARADSPALCR HLMPDGSLPE AQSLWPRPLF C         10         20         30         40         50         60
MPRYGASLRQ SCPRSGREQG QDGTAGAPGL LWMGLVLALA LALALALALS DSRVLWAPAE
        70         80         90        100        110        120
AHPLSPQGHP ARLHRIVPRL RDVFGWGNLT CPICKGLFTA INLGLKKEPN VARVGSVAIK
       130        140        150        160        170        180
LCNLLKIAPP AVCQSIVHLF EDDMVEVWRR SVLSPSEACG LLLGSTCGHW DIFSSWNISL
       190        200        210        220        230        240
PTVPKPPPKP PSPPAPGAPV SRILFLTDLH WDHDYLEGTD PDCADPLCCR RGSGLPPASR
       250        260        270        280        290        300
PGAGYWGEYS KCDLPLRTLE SLLSGLGPAG PFDMVYWTGD IPAHDVWHQT RQDQLRALTT
       310        320        330        340        350        360
VTALVRKFLG PVPVYPAVGN HESTPVNSFP PPFIEGNHSS RWLYEAMAKA WEPWLPAEAL
       370        380        390        400        410        420
RTLRIGGFYA LSPYPGLRLI SLNMNFCSRE NFWLLINSTD PAGQLQWLVG ELQAAEDRGD
       430        440        450        460        470        480
KVHIIGHIPP GHCLKSWSWN YYRIVARYEN TLAAQFFGHT HVDEFEVFYD EETLSRPLAV
       490        500        510        520        530        540
AFLAPSATTY IGLNPGYRVY QIDGNYSGSS HVVLDHETYI LNLTQANIPG AIPHWQLLYR
       550        560        570        580        590        600
ARETYGLPNT LPTAWHNLVY RMRGDMQLFQ TFWFLYHKGH PPSEPCGTPC RLATLCAQLS
       610        620        630
ARADSPALCR HLMPDGSLPE AQSLWPRPLF C         10         20         30         40         50         60
MPRYGASLRQ SCPRSGREQG QDGTAGAPGL LWMGLVLALA LALALALALS DSRVLWAPAE
        70         80         90        100        110        120
AHPLSPQGHP ARLHRIVPRL RDVFGWGNLT CPICKGLFTA INLGLKKEPN VARVGSVAIK
       130        140        150        160        170        180
LCNLLKIAPP AVCQSIVHLF EDDMVEVWRR SVLSPSEACG LLLGSTCGHW DIFSSWNISL
       190        200        210        220        230        240
PTVPKPPPKP PSPPAPGAPV SRILFLTDLH WDHDYLEGTD PDCADPLCCR RGSGLPPASR
       250        260        270        280        290        300
PGAGYWGEYS KCDLPLRTLE SLLSGLGPAG PFDMVYWTGD IPAHDVWHQT RQDQLRALTT
       310        320        330        340        350        360
VTALVRKFLG PVPVYPAVGN HESTPVNSFP PPFIEGNHSS RWLYEAMAKA WEPWLPAEAL
       370        380        390        400        410        420
RTLRIGGFYA LSPYPGLRLI SLNMNFCSRE NFWLLINSTD PAGQLQWLVG ELQAAEDRGD
       430        440        450        460        470        480
KVHIIGHIPP GHCLKSWSWN YYRIVARYEN TLAAQFFGHT HVDEFEVFYD EETLSRPLAV
       490        500        510        520        530        540
AFLAPSATTY IGLNPGYRVY QIDGNYSGSS HVVLDHETYI LNLTQANIPG AIPHWQLLYR
       550        560        570        580        590        600
ARETYGLPNT LPTAWHNLVY RMRGDMQLFQ TFWFLYHKGH PPSEPCGTPC RLATLCAQLS
       610        620        630
ARADSPALCR HLMPDGSLPE AQSLWPRPLF C

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P17405-1-unknown	MPRYGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67656
P17405-1-unknown	MPRYGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67657
P17405-1-unknown	MPRYGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67658
P17405-47-unknown	LALSDS...	47	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P17405-47-unknown	LALSDS...	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115562
P17405-47-unknown	LALSDS...	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115563
P17405-47-unknown	LALSDS...	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115564
P17405-252-unknown	CDLPLR...	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2821
P17405-252-unknown	CDLPLR...	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148420
P17405-252-unknown	CDLPLR...	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148458
P17405-252-unknown	CDLPLR...	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148459
P17405-272-unknown	FDMVYW...	272	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431479
P17405-272-unknown	FDMVYW...	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131177
P17405-272-unknown	FDMVYW...	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131175
P17405-272-unknown	FDMVYW...	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131176

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GEYSKC	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2821
...GNHEST	323	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431479
...WPRPLF	629	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WPRPLF	629	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63275
...WPRPLF	629	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63274
...WPRPLF	629	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63276

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	251	YSKC.\|.CDLP	inferred from experiment	unknown	MEROPS	Schutze S	Edelmann B et al.:Caspase-8 and caspase-7 sequent... (C14.004)	21157428,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)