TopFIND 4.0

P17707: S-adenosylmethionine decarboxylase proenzyme

General Information

Protein names
- S-adenosylmethionine decarboxylase proenzyme
- AdoMetDC
- SAMDC
- 4.1.1.50 {ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:10574985, ECO:0000269|PubMed:11583147, ECO:0000269|PubMed:1917972, ECO:0000269|PubMed:2460457, ECO:0000269|PubMed:2687270}
- S-adenosylmethionine decarboxylase alpha chain
- S-adenosylmethionine decarboxylase beta chain
Gene names AMD1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P17707

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPRSEW DILLKDVQCS IISVTKTDKQ 
        70         80         90        100        110        120 
EAYVLSESSM FVSKRRFILK TCGTTLLLKA LVPLLKLARD YSGFDSIQSF FYSRKNFMKP 
       130        140        150        160        170        180 
SHQGYPHRNF QEEIEFLNAI FPNGAAYCMG RMNSDCWYLY TLDFPESRVI SQPDQTLEIL 
       190        200        210        220        230        240 
MSELDPAVMD QFYMKDGVTA KDVTRESGIR DLIPGSVIDA TMFNPCGYSM NGMKSDGTYW 
       250        260        270        280        290        300 
TIHITPEPEF SYVSFETNLS QTSYDDLIRK VVEVFKPGKF VTTLFVNQSS KCRTVLASPQ 
       310        320        330    
KIEGFKRLDC QSAMFNDYNF VFTSFAKKQQ QQQS

Isoforms

- Isoform 2 of S-adenosylmethionine decarboxylase proenzyme

Sequence View

        10         20         30         40         50         60 
MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPRSEW DILLKDVQCS IISVTKTDKQ 
        70         80         90        100        110        120 
EAYVLSESSM FVSKRRFILK TCGTTLLLKA LVPLLKLARD YSGFDSIQSF FYSRKNFMKP 
       130        140        150        160        170        180 
SHQGYPHRNF QEEIEFLNAI FPNGAAYCMG RMNSDCWYLY TLDFPESRVI SQPDQTLEIL 
       190        200        210        220        230        240 
MSELDPAVMD QFYMKDGVTA KDVTRESGIR DLIPGSVIDA TMFNPCGYSM NGMKSDGTYW 
       250        260        270        280        290        300 
TIHITPEPEF SYVSFETNLS QTSYDDLIRK VVEVFKPGKF VTTLFVNQSS KCRTVLASPQ 
       310        320        330    
KIEGFKRLDC QSAMFNDYNF VFTSFAKKQQ QQQS



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P17707-1-unknown MEAAHF... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P17707-68-Pyruvic acid (Ser) SSMFVS... 68 pyruvate- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P17707-149-unknown MGRMNS... 149 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt72429

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)