P17710: Hexokinase-1

General Information

Protein names	- Hexokinase-1 - 2.7.1.1 - Hexokinase type I - HK I - Hexokinase, tumor isozyme
Gene names	Hk1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P17710

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform HK1-SB of Hexokinase-1 - Isoform HK1 of Hexokinase-1 - Isoform HK1-SC of Hexokinase-1

Sequence View

        10         20         30         40         50         60
MGWGAPLLSR MLHGPGQAGE TSPVPERQSG SENPASEDRR PLEKQCSHHL YTMGQNCQRG
        70         80         90        100        110        120
QAVDVEPKIR PPLTEEKIDK YLYAMRLSDE ILIDILTRFK KEMKNGLSRD YNPTASVKML
       130        140        150        160        170        180
PTFVRSIPDG SEKGDFIALD LGGSSFRILR VQVNHEKSQN VSMESEVYDT PENIVHGSGS
       190        200        210        220        230        240
QLFDHVAECL GDFMEKRKIK DKKLPVGFTF SFPCRQSKID EAVLITWTKR FKASGVEGAD
       250        260        270        280        290        300
VVKLLNKAIK KRGDYDANIV AVVNDTVGTM MTCGYDDQQC EVGLIIGTGT NACYMEELRH
       310        320        330        340        350        360
IDLVEGDEGR MCINTEWGAF GDDGSLEDIR TEFDRELDRG SLNPGKQLFE KMVSGMYMGE
       370        380        390        400        410        420
LVRLILVKMA KESLLFEGRI TPELLTRGKF TTSDVAAIET DKEGVQNAKE ILTRLGVEPS
       430        440        450        460        470        480
HDDCVSVQHV CTIVSFRSAN LVAATLGAIL NRLRDNKGTP RLRTTVGVDG SLYKMHPQYS
       490        500        510        520        530        540
RRFHKTLRRL VPDSDVRFLL SESGSGKGAA MVTAVAYRLA EQHRQIEETL SHFRLSKQAL
       550        560        570        580        590        600
MEVKKKLRSE MEMGLRKETN SRATVKMLPS YVRSIPDGTE HGDFLALDLG GTNFRVLLVK
       610        620        630        640        650        660
IRSGKKRTVE MHNKIYSIPL EIMQGTGDEL FDHIVSCISD FLDYMGIKGP RMPLGFTFSF
       670        680        690        700        710        720
PCKQTSLDCG ILITWTKGFK ATDCVGHDVA TLLRDAVKRR EEFDLDVVAV VNDTVGTMMT
       730        740        750        760        770        780
CAYEEPSCEI GLIVGTGSNA CYMEEMKNVE MVEGNQGQMC INMEWGAFGD NGCLDDIRTD
       790        800        810        820        830        840
FDKVVDEYSL NSGKQRFEKM ISGMYLGEIV RNILIDFTKK GFLFRGQISE PLKTRGIFET
       850        860        870        880        890        900
KFLSQIESDR LALLQVRAIL QQLGLNSTCD DSILVKTVCG VVSKRAAQLC GAGMAAVVEK
       910        920        930        940        950        960
IRENRGLDHL NVTVGVDGTL YKLHPHFSRI MHQTVKELSP KCTVSFLLSE DGSGKGAALI
       970
TAVGVRLRGD PTNA         10         20         30         40         50         60
MGWGAPLLSR MLHGPGQAGE TSPVPERQSG SENPASEDRR PLEKQCSHHL YTMGQNCQRG
        70         80         90        100        110        120
QAVDVEPKIR PPLTEEKIDK YLYAMRLSDE ILIDILTRFK KEMKNGLSRD YNPTASVKML
       130        140        150        160        170        180
PTFVRSIPDG SEKGDFIALD LGGSSFRILR VQVNHEKSQN VSMESEVYDT PENIVHGSGS
       190        200        210        220        230        240
QLFDHVAECL GDFMEKRKIK DKKLPVGFTF SFPCRQSKID EAVLITWTKR FKASGVEGAD
       250        260        270        280        290        300
VVKLLNKAIK KRGDYDANIV AVVNDTVGTM MTCGYDDQQC EVGLIIGTGT NACYMEELRH
       310        320        330        340        350        360
IDLVEGDEGR MCINTEWGAF GDDGSLEDIR TEFDRELDRG SLNPGKQLFE KMVSGMYMGE
       370        380        390        400        410        420
LVRLILVKMA KESLLFEGRI TPELLTRGKF TTSDVAAIET DKEGVQNAKE ILTRLGVEPS
       430        440        450        460        470        480
HDDCVSVQHV CTIVSFRSAN LVAATLGAIL NRLRDNKGTP RLRTTVGVDG SLYKMHPQYS
       490        500        510        520        530        540
RRFHKTLRRL VPDSDVRFLL SESGSGKGAA MVTAVAYRLA EQHRQIEETL SHFRLSKQAL
       550        560        570        580        590        600
MEVKKKLRSE MEMGLRKETN SRATVKMLPS YVRSIPDGTE HGDFLALDLG GTNFRVLLVK
       610        620        630        640        650        660
IRSGKKRTVE MHNKIYSIPL EIMQGTGDEL FDHIVSCISD FLDYMGIKGP RMPLGFTFSF
       670        680        690        700        710        720
PCKQTSLDCG ILITWTKGFK ATDCVGHDVA TLLRDAVKRR EEFDLDVVAV VNDTVGTMMT
       730        740        750        760        770        780
CAYEEPSCEI GLIVGTGSNA CYMEEMKNVE MVEGNQGQMC INMEWGAFGD NGCLDDIRTD
       790        800        810        820        830        840
FDKVVDEYSL NSGKQRFEKM ISGMYLGEIV RNILIDFTKK GFLFRGQISE PLKTRGIFET
       850        860        870        880        890        900
KFLSQIESDR LALLQVRAIL QQLGLNSTCD DSILVKTVCG VVSKRAAQLC GAGMAAVVEK
       910        920        930        940        950        960
IRENRGLDHL NVTVGVDGTL YKLHPHFSRI MHQTVKELSP KCTVSFLLSE DGSGKGAALI
       970
TAVGVRLRGD PTNA         10         20         30         40         50         60
MGWGAPLLSR MLHGPGQAGE TSPVPERQSG SENPASEDRR PLEKQCSHHL YTMGQNCQRG
        70         80         90        100        110        120
QAVDVEPKIR PPLTEEKIDK YLYAMRLSDE ILIDILTRFK KEMKNGLSRD YNPTASVKML
       130        140        150        160        170        180
PTFVRSIPDG SEKGDFIALD LGGSSFRILR VQVNHEKSQN VSMESEVYDT PENIVHGSGS
       190        200        210        220        230        240
QLFDHVAECL GDFMEKRKIK DKKLPVGFTF SFPCRQSKID EAVLITWTKR FKASGVEGAD
       250        260        270        280        290        300
VVKLLNKAIK KRGDYDANIV AVVNDTVGTM MTCGYDDQQC EVGLIIGTGT NACYMEELRH
       310        320        330        340        350        360
IDLVEGDEGR MCINTEWGAF GDDGSLEDIR TEFDRELDRG SLNPGKQLFE KMVSGMYMGE
       370        380        390        400        410        420
LVRLILVKMA KESLLFEGRI TPELLTRGKF TTSDVAAIET DKEGVQNAKE ILTRLGVEPS
       430        440        450        460        470        480
HDDCVSVQHV CTIVSFRSAN LVAATLGAIL NRLRDNKGTP RLRTTVGVDG SLYKMHPQYS
       490        500        510        520        530        540
RRFHKTLRRL VPDSDVRFLL SESGSGKGAA MVTAVAYRLA EQHRQIEETL SHFRLSKQAL
       550        560        570        580        590        600
MEVKKKLRSE MEMGLRKETN SRATVKMLPS YVRSIPDGTE HGDFLALDLG GTNFRVLLVK
       610        620        630        640        650        660
IRSGKKRTVE MHNKIYSIPL EIMQGTGDEL FDHIVSCISD FLDYMGIKGP RMPLGFTFSF
       670        680        690        700        710        720
PCKQTSLDCG ILITWTKGFK ATDCVGHDVA TLLRDAVKRR EEFDLDVVAV VNDTVGTMMT
       730        740        750        760        770        780
CAYEEPSCEI GLIVGTGSNA CYMEEMKNVE MVEGNQGQMC INMEWGAFGD NGCLDDIRTD
       790        800        810        820        830        840
FDKVVDEYSL NSGKQRFEKM ISGMYLGEIV RNILIDFTKK GFLFRGQISE PLKTRGIFET
       850        860        870        880        890        900
KFLSQIESDR LALLQVRAIL QQLGLNSTCD DSILVKTVCG VVSKRAAQLC GAGMAAVVEK
       910        920        930        940        950        960
IRENRGLDHL NVTVGVDGTL YKLHPHFSRI MHQTVKELSP KCTVSFLLSE DGSGKGAALI
       970
TAVGVRLRGD PTNA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P17710-1-unknown	MGWGAP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P17710-53-unknown	MGQNCQ...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77363
P17710-53-unknown	MGQNCQ...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77365
P17710-444-unknown	ATLGAI...	444	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29793
P17710-444-unknown	ATLGAI...	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151802
P17710-444-unknown	ATLGAI...	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151875
P17710-444-unknown	ATLGAI...	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152249
P17710-585-unknown	LALDLG...	585	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29797
P17710-585-unknown	LALDLG...	585	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153741
P17710-585-unknown	LALDLG...	585	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153786
P17710-585-unknown	LALDLG...	585	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154052
P17710-947-unknown	LLSEDG...	947	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29801
P17710-947-unknown	LLSEDG...	947	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156835
P17710-947-unknown	LLSEDG...	947	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156845
P17710-947-unknown	LLSEDG...	947	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156960

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ANLVAA	443	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29793
...ANLVAA	443	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135206
...ANLVAA	443	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135280
...ANLVAA	443	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135659
...EHGDFL	584	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29797
...EHGDFL	584	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137163
...EHGDFL	584	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137208
...EHGDFL	584	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137471
...CTVSFL	946	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29801
...CTVSFL	946	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140329
...CTVSFL	946	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140342
...CTVSFL	946	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140451
...DPTNA	974	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DPTNA	974	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72982
...DPTNA	974	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72983
...DPTNA	974	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72981

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	443	LVAA.\|.ATLG	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> HXK1_MOUSE @443
CATE_MOUSE	584	GDFL.\|.LALD	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> HXK1_MOUSE @584
CATE_MOUSE	946	VSFL.\|.LLSE	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> HXK1_MOUSE @946

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)