TopFIND 4.0

P17752: Tryptophan 5-hydroxylase 1

General Information

Protein names
- Tryptophan 5-hydroxylase 1
- 1.14.16.4
- Tryptophan 5-monooxygenase 1
Gene names TPH1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P17752

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES RKSKRRNSEF 
        70         80         90        100        110        120 
EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED GMETVPWFPK KISDLDHCAN 
       130        140        150        160        170        180 
RVLMYGSELD ADHPGFKDNV YRKRRKYFAD LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE 
       190        200        210        220        230        240 
LNKLYPTHAC REYLKNLPLL SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD 
       250        260        270        280        290        300 
FLSGLAFRVF HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA 
       310        320        330        340        350        360 
SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK VKPFDPKITC 
       370        380        390        400        410        420 
KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK YNPYTRSIQI LKDTKSITSA 
       430        440    
MNELQHDLDV VSDALAKVSR KPSI

Isoforms

- Isoform 2 of Tryptophan 5-hydroxylase 1

Sequence View

        10         20         30         40         50         60 
MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES RKSKRRNSEF 
        70         80         90        100        110        120 
EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED GMETVPWFPK KISDLDHCAN 
       130        140        150        160        170        180 
RVLMYGSELD ADHPGFKDNV YRKRRKYFAD LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE 
       190        200        210        220        230        240 
LNKLYPTHAC REYLKNLPLL SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD 
       250        260        270        280        290        300 
FLSGLAFRVF HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA 
       310        320        330        340        350        360 
SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK VKPFDPKITC 
       370        380        390        400        410        420 
KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK YNPYTRSIQI LKDTKSITSA 
       430        440    
MNELQHDLDV VSDALAKVSR KPSI



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P17752-1-unknown MIEDNK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P17752-1-unknown MIEDNK... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt92844

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...RKPSI 444 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)