TopFIND 4.0

P18292: Prothrombin

General Information

Protein names
- Prothrombin
- 3.4.21.5
- Coagulation factor II
- Activation peptide fragment 1
- Activation peptide fragment 2
- Thrombin light chain
- Thrombin heavy chain
Gene names F2
Organism Rattus norvegicus
Protease Family
Protease ID S01.217
Chromosome location
UniProt ID P18292

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLHVRGLGLP GCLALAALAS LVHSQHVFLA PQQALSLLQR VRRANSGFLE ELRKGNLERE 
        70         80         90        100        110        120 
CVEEQCSYEE AFEALESPQD TDVFWAKYTV CDSVRKPRET FMDCLEGRCA MDLGLNYHGN 
       130        140        150        160        170        180 
VSVTHTGIEC QLWRSRYPHR PDINSTTHPG ADLKENFCRN PDSSTSGPWC YTTDPTVRRE 
       190        200        210        220        230        240 
ECSIPVCGQE GRTTVKMTPR SRGSKENLSP PLGECLLERG RLYQGNLAVT TLGSPCLAWD 
       250        260        270        280        290        300 
SLPTKTLSKY QNFDPEVKLV QNFCRNPDRD EEGAWCFVAQ QPGFEYCSLN YCDEAVGEEN 
       310        320        330        340        350        360 
HDGDESIAGR TTDAEFHTFF DERTFGLGEA DCGLRPLFEK KSLTDKTEKE LLDSYIDGRI 
       370        380        390        400        410        420 
VEGWDAEKGI APWQVMLFRK SPQELLCGAS LISDRWVLTA AHCILYPPWD KNFTENDLLV 
       430        440        450        460        470        480 
RIGKHSRTRY ERNVEKISML EKIYIHPRYN WRENLDRDIA LLKLKKPVPF SDYIHPVCLP 
       490        500        510        520        530        540 
DKQTVTSLLQ AGYKGRVTGW GNLRETWTTN INEIQPSVLQ VVNLPIVERP VCKASTRIRI 
       550        560        570        580        590        600 
TDNMFCAGFK VNDTKRGDAC EGDSGGPFVM KSPYNHRWYQ MGIVSWGEGC DRNGKYGFYT 
       610    
HVFRLKRWMQ KVIDQHR

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P18292-44-unknown ANSGFL... 44 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P18292-324-unknown TFGLGE... 324 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P18292-360-unknown IVEGWD... 360 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YIDGRI 359 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...IDQHR 617 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)