P18858: DNA ligase 1

General Information

Protein names	- DNA ligase 1 - 6.5.1.1 {ECO:0000255\|PROSITE-ProRule:PRU10135} - DNA ligase I - Polydeoxyribonucleotide synthase ATP] 1
Gene names	LIG1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P18858

7 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA
        70         80         90        100        110        120
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK
       130        140        150        160        170        180
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEEETP KESLTEAEVA TEKEGEDGDQ
       190        200        210        220        230        240
PTTPPKPLKT SKAETPTESV SEPEVATKQE LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK
       250        260        270        280        290        300
KEVKEEEPGA PGKEGAAEGP LDPSGYNPAK NNYHPVEDAC WKPGQKVPYL AVARTFEKIE
       310        320        330        340        350        360
EVSARLRMVE TLSNLLRSVV ALSPPDLLPV LYLSLNHLGP PQQGLELGVG DGVLLKAVAQ
       370        380        390        400        410        420
ATGRQLESVR AEAAEKGDVG LVAENSRSTQ RLMLPPPPLT ASGVFSKFRD IARLTGSAST
       430        440        450        460        470        480
AKKIDIIKGL FVACRHSEAR FIARSLSGRL RLGLAEQSVL AALSQAVSLT PPGQEFPPAM
       490        500        510        520        530        540
VDAGKGKTAE ARKTWLEEQG MILKQTFCEV PDLDRIIPVL LEHGLERLPE HCKLSPGIPL
       550        560        570        580        590        600
KPMLAHPTRG ISEVLKRFEE AAFTCEYKYD GQRAQIHALE GGEVKIFSRN QEDNTGKYPD
       610        620        630        640        650        660
IISRIPKIKL PSVTSFILDT EAVAWDREKK QIQPFQVLTT RKRKEVDASE IQVQVCLYAF
       670        680        690        700        710        720
DLIYLNGESL VREPLSRRRQ LLRENFVETE GEFVFATSLD TKDIEQIAEF LEQSVKDSCE
       730        740        750        760        770        780
GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL
       790        800        810        820        830        840
ASYDEDSEEL QAICKLGTGF SDEELEEHHQ SLKALVLPSP RPYVRIDGAV IPDHWLDPSA
       850        860        870        880        890        900
VWEVKCADLS LSPIYPAARG LVDSDKGISL RFPRFIRVRE DKQPEQATTS AQVACLYRKQ
       910
SQIQNQQGED SGSDPEDTY

Isoforms

- Isoform 2 of DNA ligase 1 - Isoform 3 of DNA ligase 1

Sequence View

        10         20         30         40         50         60
MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA
        70         80         90        100        110        120
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK
       130        140        150        160        170        180
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEEETP KESLTEAEVA TEKEGEDGDQ
       190        200        210        220        230        240
PTTPPKPLKT SKAETPTESV SEPEVATKQE LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK
       250        260        270        280        290        300
KEVKEEEPGA PGKEGAAEGP LDPSGYNPAK NNYHPVEDAC WKPGQKVPYL AVARTFEKIE
       310        320        330        340        350        360
EVSARLRMVE TLSNLLRSVV ALSPPDLLPV LYLSLNHLGP PQQGLELGVG DGVLLKAVAQ
       370        380        390        400        410        420
ATGRQLESVR AEAAEKGDVG LVAENSRSTQ RLMLPPPPLT ASGVFSKFRD IARLTGSAST
       430        440        450        460        470        480
AKKIDIIKGL FVACRHSEAR FIARSLSGRL RLGLAEQSVL AALSQAVSLT PPGQEFPPAM
       490        500        510        520        530        540
VDAGKGKTAE ARKTWLEEQG MILKQTFCEV PDLDRIIPVL LEHGLERLPE HCKLSPGIPL
       550        560        570        580        590        600
KPMLAHPTRG ISEVLKRFEE AAFTCEYKYD GQRAQIHALE GGEVKIFSRN QEDNTGKYPD
       610        620        630        640        650        660
IISRIPKIKL PSVTSFILDT EAVAWDREKK QIQPFQVLTT RKRKEVDASE IQVQVCLYAF
       670        680        690        700        710        720
DLIYLNGESL VREPLSRRRQ LLRENFVETE GEFVFATSLD TKDIEQIAEF LEQSVKDSCE
       730        740        750        760        770        780
GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL
       790        800        810        820        830        840
ASYDEDSEEL QAICKLGTGF SDEELEEHHQ SLKALVLPSP RPYVRIDGAV IPDHWLDPSA
       850        860        870        880        890        900
VWEVKCADLS LSPIYPAARG LVDSDKGISL RFPRFIRVRE DKQPEQATTS AQVACLYRKQ
       910
SQIQNQQGED SGSDPEDTY         10         20         30         40         50         60
MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA
        70         80         90        100        110        120
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK
       130        140        150        160        170        180
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEEETP KESLTEAEVA TEKEGEDGDQ
       190        200        210        220        230        240
PTTPPKPLKT SKAETPTESV SEPEVATKQE LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK
       250        260        270        280        290        300
KEVKEEEPGA PGKEGAAEGP LDPSGYNPAK NNYHPVEDAC WKPGQKVPYL AVARTFEKIE
       310        320        330        340        350        360
EVSARLRMVE TLSNLLRSVV ALSPPDLLPV LYLSLNHLGP PQQGLELGVG DGVLLKAVAQ
       370        380        390        400        410        420
ATGRQLESVR AEAAEKGDVG LVAENSRSTQ RLMLPPPPLT ASGVFSKFRD IARLTGSAST
       430        440        450        460        470        480
AKKIDIIKGL FVACRHSEAR FIARSLSGRL RLGLAEQSVL AALSQAVSLT PPGQEFPPAM
       490        500        510        520        530        540
VDAGKGKTAE ARKTWLEEQG MILKQTFCEV PDLDRIIPVL LEHGLERLPE HCKLSPGIPL
       550        560        570        580        590        600
KPMLAHPTRG ISEVLKRFEE AAFTCEYKYD GQRAQIHALE GGEVKIFSRN QEDNTGKYPD
       610        620        630        640        650        660
IISRIPKIKL PSVTSFILDT EAVAWDREKK QIQPFQVLTT RKRKEVDASE IQVQVCLYAF
       670        680        690        700        710        720
DLIYLNGESL VREPLSRRRQ LLRENFVETE GEFVFATSLD TKDIEQIAEF LEQSVKDSCE
       730        740        750        760        770        780
GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL
       790        800        810        820        830        840
ASYDEDSEEL QAICKLGTGF SDEELEEHHQ SLKALVLPSP RPYVRIDGAV IPDHWLDPSA
       850        860        870        880        890        900
VWEVKCADLS LSPIYPAARG LVDSDKGISL RFPRFIRVRE DKQPEQATTS AQVACLYRKQ
       910
SQIQNQQGED SGSDPEDTY

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P18858-1-unknown	MQRSIM...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18858-4-unknown	SIMSFF...	4		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P18858-4-	SIMSFF...	4		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P18858-223-unknown	RAPKTL...	223		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P18858-223-	RAPKTL...	223		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P18858-227-unknown	TLSSFF...	227		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P18858-227-unknown	TLSSFF...	227	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18858-227-unknown	TLSSFF...	227	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P18858-227-	TLSSFF...	227		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASNSSR	28	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472085
...SEDEDR	145	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469638
...EEEEQT	217	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471861
...PEDTY	919	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

TopFIND

P18858: DNA ligase 1

General Information

7

N-termini

4

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Methodology:

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates